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Botox May Ease Tremors in Multiple Sclerosis Patients
Date:7/2/2012

By Randy Dotinga
HealthDay Reporter

MONDAY, July 2 (HealthDay News) -- The drug Botox, best known for paralyzing muscles in the forehead to reduce wrinkles, can also relieve shaking in the limbs of patients with multiple sclerosis, a small new study suggests.

The treatment, which requires several times the amount of Botox (botulinum toxin type A) used for wrinkles, could be expensive and it's not yet approved by the U.S. Food and Drug Administration for this use. However, multiple sclerosis (MS) patients can still legally get the treatment in the United States.

"Most patients tolerate the injections very well and are keen to continue the treatment once they see the benefits they get from it," said Dr. Anneke van der Walt, lead study author and a neurologist and research fellow at the Royal Melbourne Hospital, in Australia.

The shaking, known as a tremor, can affect one or both arms, or less commonly the legs, in MS patients. "The shaking affects them when they're just trying to hold the arms up or do common daily tasks such as eating and drinking, shaving and, particularly, writing," van der Walt said. "As with many MS symptoms, the tremor can be worse on very hot days and worse when the person is tired."

Physicians may turn to medications to treat the tremors, but the drugs often have little effect, van der Walt said. Brain surgery to implant electrodes is another option to relieve the tremors, but the benefits may not last long.

In the new study, researchers randomly gave Botox or an inactive placebo by injection to 23 MS patients with tremors in their arms. Twelve weeks later, they reversed the injections so each arm ultimately received both Botox and placebo.

The investigators assessed tremor severity and a variety of motor skills before and after treatment.

According to the study, published in the July 3 issue of the journal Neurology, after Botox injection, the patients h
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