Navigation Links
Botox Alternative May Safely Smooth Forehead Lines
Date:3/16/2009

Reloxin is already approved outside US, but not all experts are convinced by new study,,,,

MONDAY, March 16 (HealthDay News) -- A new type of Botox drug called Reloxin appears safe and effective in reducing forehead wrinkles, a new study finds.

The use of Botox to reduce forehead wrinkles and frown lines has long been a mainstay of cosmetic medicine. The medication works by preventing face muscles from contracting, an effect that lasts for several months.

As an alternative to Botox, Reloxin is now approved in 23 countries outside the United States to smooth wrinkles, the researchers noted. The drug has also been used outside the United States for more than 15 years to treat neurological disorders.

One of the differences between Botox and Reloxin is that Reloxin has less protein in its formula, noted Dr. Kamran Jafri, from Jafri Craniofacial Plastic Surgery, New York City. Reloxin also contains fewer antigens, which cause the drug to break down more quickly, said Jafri, who was not involved in the new study.

"Theoretically, because Reloxin has less of a protein load the body will break it down at a slower rate. That means from a clinical perspective that it should last longer than Botox," he said. "However, some of the early trials are showing that Botox actually lasts longer than Reloxin."

Another difference between the drugs is that Reloxin defuses more in the tissue than Botox, Jafri said. "Botox typically defuses in about a one centimeter radius, Reloxin can go anywhere from one to three centimeters," he said. "That's a good thing for the forehead, where you can give fewer injections, but it's a bad thing for, say, crow's feet, where unless you are an experienced injector and you know the muscles very well, it could spread to other muscles and cause a droopy eyebrow or droopy eyelid," he explained.

In this phase III trial, Reloxin's wrinkle-smoothing effects lasted more than 13 months. And although the drug is still awaiting approval from the U.S. Food and Drug Administration, it could someday become a serious competitor to Botox, the researchers said.

"Reloxin is as safe and it works as well as Botox," said lead researcher Dr. Ronald Moy from the Moy-Fincher Medical Group in Los Angeles. "Many of our patients are happier and got a more natural look with the use of Reloxin."

"I think this will be as popular as Botox, which is the most common cosmetic procedure in the United States," Moy added.

But not all plastic surgeons are as enthusiastic, with some citing a heightened incidence of drooping of the eyelid and/or brow with Reloxin vs. Botox. "With this study, I don't see a clear advantage over Botox," said Dr. Jeffrey C. Salomon, an assistant clinical professor of plastic surgery at Yale University School of Medicine.

The report, which was funded by the drug's maker, Medicis Pharmaceutical Corp., is published in the March/April issue of the Archives of Facial Plastic Surgery.

For the study, Moy's team treated 1,200 patients with injections of Reloxin (Clostridium botulinum toxin type A-hemagglutinin complex) in five sites in the forehead. Patients kept diaries of the effects of the treatment and were surveyed a week to 10 days after treatment. In addition, patients were reexamined two weeks and 30 days later, and then each month after treatment.

Among the 1,052 patients who completed the 13-month study there were 2,838 adverse events among 880 patients. Of these, 28 percent were probably related to the treatment. These included problems at the injection site, nervous system disorders such as headache and eye problems including ptosis, a drooping of the eyelid or brow. Only one patient withdrew from study due to the side effects of the drug, the researchers say.

Patients reported that the drug started working within a day after treatment. After a week, as many as 95 percent of the patients reported showing a response to the medication. At 30 days after treatment, as many as 91 percent of the patients had a response, according to the researcher's assessment.

Dr. Brent Moelleken, a plastic and reconstructive surgeon in Beverly Hills and Santa Barbara, Calif., noted that Reloxin has not yet been compared head-to-head with Botox.

"The safety profile appears similar to Botox, but perhaps more drooping than is usual with Botox," Moelleken said. "The big question about how Reloxin works, the volume of distribution, was not addressed, or technical differences, which may account for the greater drooping than most injectors see with Botox."

For his part, Salomon said he is "concerned with the increased incidence of ptosis [with Reloxin] and the lack of specificity of that ptosis -- brow versus lids. If it is all lid ptosis then I would consider it as an unintended spread of the material beyond the desired treatment area. That would not be a helpful or predictable component in the product's use," he said.

More information

For more information on Botox, visit the U.S. National Library of Medicine .



SOURCES: Ronald Moy, M.D., Moy-Fincher Medical Group, Los Angeles; Brent Moelleken, M.D., plastic and reconstructive surgeon, Beverly Hills and Santa Barbara, Calif.; Jeffrey C. Salomon, M.D., assistant clinical professor, plastic surgery, Yale University School of Medicine, New Haven, Conn.; Kamran Jafri, M.D., Jafri Craniofacial Plastic Surgery, New York City; March/April 2009 Archives of Facial Plastic Surgery


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Facelift, Botox, or Both? Depends Upon Your Decade of Life
2. Botox Offers Shot in Arm for Arthritis Sufferers
3. UT Southwestern urologist uses Botox to treat debilitating condition
4. Men need more Botox than women
5. ASPS Addresses Concerns Regarding BOTOX Treatments
6. American Society for Dermatologic Surgery Supports Current Labeling of Allergans Botox(R) Products
7. The American Society for Aesthetic Plastic Surgery Addresses the Safety of Botox
8. FDA Warns of Childrens Deaths Linked to Botox
9. Botox Cosmetic Alternatives Are Available: Surgical Procedures Offer Solution for Wrinkles
10. AAFPRS Speaks to the Safety of BOTOX(R) Cosmetic
11. Clarity for Consumers on Botox Complication and Death Reports
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Botox Alternative May Safely Smooth Forehead Lines
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned ... developed to enhance the health of felines. The formula is all-natural and is made ... in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin ... injury. Recently, he has implemented orthobiologic procedures as a method for treating his ... of the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... -- One of Australia,s successful biotechnology scientists, ... new biotechnology company, Noxopharm Limited [ABN 50 608 966 123] ("Noxopharm"). ... list on the ASX. Noxopharm is a clinic-ready company ... Phase 1 clinical study later this year. ... biggest problems facing cancer patients - the ability of cancers to ...
(Date:6/26/2016)... June 27, 2016 Jazz Pharmaceuticals plc (Nasdaq: ... under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as ... Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: CPXX ) ... Daylight Time). As previously announced on May ... definitive merger agreement under which Jazz Pharmaceuticals has commenced ...
(Date:6/26/2016)... 2016  VMS Rehab Systems, Inc. ( www.vmsrehabsystemsinc.com ) ... measures required to build a strong and stable market ... listed on the OTC Markets-pink current trading platform. ... "We are seeing an anomaly in market trading activities ... by the Company, but shareholders and market players as ...
Breaking Medicine Technology: