Navigation Links
Boston college biologist awarded NIH grant to probe link between HIV and peripheral neuropathy
Date:2/5/2013

CHESTNUT HILL, MA (Feb. 5, 2013) Boston College biologist Tricia Burdo has been awarded a five-year, $1.9 million grant from the National Institutes of Health to study the role of the body's immune response in a debilitating form of nerve damage suffered by people living with HIV.

Among HIV patients, as many as 69.4 percent are afflicted with peripheral neuropathy of the arms, legs, hands, feet, fingers and toes. The most common neurological disorder associated with people living with HIV, it is known as "dying back", a painful condition where sensory nerves die and then retreat, causing a loss of sensitivity and function.

Burdo, an associate research professor in the lab of Professor of Biology Ken Williams, said the group has been exploring the connection between peripheral neuropathy and inflammation in the dorsal root ganglia located outside of the spine. The focal point is macrophage activation, the disruptive activity of cells associated with the body's immunological response to infection.

The presence and behavior of those cells could help to determine what triggers peripheral neuropathy in HIV patients, Burdo said.

"We're studying what's going on in dorsal root ganglia in terms of inflammation by macrophage activation and correlating that to this nerve loss," said Burdo.

Central to the study, funded by the NIH's National Institute of Neurological Disorders and Stroke (NINDS), is the molecule CD163, identified by Burdo and Williams as a biological marker for the activation of macrophages and monocytes in patients with HIV.

Burdo said the team hopes to develop a clearer understanding of the progression of peripheral neuropathy, how to pinpoint early and advanced stages of neuropathy with biomarkers, and potential drug therapies that could stop or slow the disease.


'/>"/>

Contact: Ed Hayward
ed.hayward@bc.edu
617-552-4826
Boston College
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers Identify Involuntary Tobacco Smoke Exposure in Boston Public Housing Authority Residents with Salivary Cotinine Testing from Salimetrics.
2. The Boston Eye Group Implants First Intraocular Pressure Transducer for Glaucoma Monitoring
3. Linguists to gather in Boston for National Conference
4. Northofbostonusa.com Will Release its N5 Fashion Shoes Next Monday
5. Boston College researcher looks to stop a deadly parasite in its tracks
6. Boston Medical Center awarded elite distinction as a 2012 Leapfrog Top Hospital
7. Cincinnati and Boston Childrens Hospitals receive an NIH Autism Center of Excellence Grant
8. Boston University researchers expand synthetic biologys toolkit
9. Snoring Isn’t Sexy Member, Dr. Mark Levy attends the American Academy of Dental Sleep Medicine Meeting in Boston, MA
10. SLEEP 2012 presents latest in sleep medicine and research June 11-13 in Boston
11. Boston researcher, surgical oncologist receives national award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... CA (PRWEB) , ... March 24, 2017 , ... ... Ramin Assili, announce that they are now offering treatments for sleep apnea and ... at dental offices. Sleep apnea , specifically the obstructive type, is increasingly ...
(Date:3/24/2017)... ... March 24, 2017 , ... The law firm of ... is pleased to announce Westchester resident Lauren C. Enea has joined the firm as ... firm, will concentrate her practice in elder law, Medicaid planning and applications, and Wills, ...
(Date:3/24/2017)... ... March 24, 2017 , ... Gastro Health ... to prep patients for colonoscopy at the HyGIeaCare® Center that is to be ... FL. , The HyGIeaCare® Prep, cleared by the U.S. Food and ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... the first Certified Medical Reiki™ Master in Frederick, MD. Judy says, “I am ... caregivers during what is often a very difficult and challenging time.” , A ...
(Date:3/24/2017)... , ... March 24, 2017 , ... “End Time GPS”: ... salient events will interrelate. “End Time GPS” is the creation of published author, ... expert while working on military munitions and space-vehicle projects. Now, at age ninety-one, he ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... DUBLIN , Mar. 24, 2017 Research and ... Size, Share, Development, Growth and Demand Forecast to 2022" report to ... The global ... expected to grow at a CAGR of 6.7% during 2016-2022 ... segment held the largest share in the global market in 2015. Among ...
(Date:3/24/2017)... March 24, 2017 FinancialBuzz.com News Commentary  ... According ... of cannabis market research, the legal cannabis market is projected ... 2021, despite conflicting signals from the current presidential administration. The ... the two biggest drivers of growth in this industry are ...
(Date:3/24/2017)... Global Ampoules Market report provides ... applications and industry chain structure. The Ampoules market analysis ... competitive landscape analysis, and major regions, development status. ... ... providing 10 company profiles and 183 tables and figures ...
Breaking Medicine Technology: