Navigation Links
Boston college biologist awarded NIH grant to probe link between HIV and peripheral neuropathy
Date:2/5/2013

CHESTNUT HILL, MA (Feb. 5, 2013) Boston College biologist Tricia Burdo has been awarded a five-year, $1.9 million grant from the National Institutes of Health to study the role of the body's immune response in a debilitating form of nerve damage suffered by people living with HIV.

Among HIV patients, as many as 69.4 percent are afflicted with peripheral neuropathy of the arms, legs, hands, feet, fingers and toes. The most common neurological disorder associated with people living with HIV, it is known as "dying back", a painful condition where sensory nerves die and then retreat, causing a loss of sensitivity and function.

Burdo, an associate research professor in the lab of Professor of Biology Ken Williams, said the group has been exploring the connection between peripheral neuropathy and inflammation in the dorsal root ganglia located outside of the spine. The focal point is macrophage activation, the disruptive activity of cells associated with the body's immunological response to infection.

The presence and behavior of those cells could help to determine what triggers peripheral neuropathy in HIV patients, Burdo said.

"We're studying what's going on in dorsal root ganglia in terms of inflammation by macrophage activation and correlating that to this nerve loss," said Burdo.

Central to the study, funded by the NIH's National Institute of Neurological Disorders and Stroke (NINDS), is the molecule CD163, identified by Burdo and Williams as a biological marker for the activation of macrophages and monocytes in patients with HIV.

Burdo said the team hopes to develop a clearer understanding of the progression of peripheral neuropathy, how to pinpoint early and advanced stages of neuropathy with biomarkers, and potential drug therapies that could stop or slow the disease.


'/>"/>

Contact: Ed Hayward
ed.hayward@bc.edu
617-552-4826
Boston College
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers Identify Involuntary Tobacco Smoke Exposure in Boston Public Housing Authority Residents with Salivary Cotinine Testing from Salimetrics.
2. The Boston Eye Group Implants First Intraocular Pressure Transducer for Glaucoma Monitoring
3. Linguists to gather in Boston for National Conference
4. Northofbostonusa.com Will Release its N5 Fashion Shoes Next Monday
5. Boston College researcher looks to stop a deadly parasite in its tracks
6. Boston Medical Center awarded elite distinction as a 2012 Leapfrog Top Hospital
7. Cincinnati and Boston Childrens Hospitals receive an NIH Autism Center of Excellence Grant
8. Boston University researchers expand synthetic biologys toolkit
9. Snoring Isn’t Sexy Member, Dr. Mark Levy attends the American Academy of Dental Sleep Medicine Meeting in Boston, MA
10. SLEEP 2012 presents latest in sleep medicine and research June 11-13 in Boston
11. Boston researcher, surgical oncologist receives national award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... May 31, 2016 , ... Presence Technology ... has been included by Gartner, Inc. in the Contact Center Infrastructure Magic Quadrant ... Center Infrastructure technologies, some of which include: Computer-telephony integration (CTI)/Web services interfaces, ...
(Date:5/31/2016)... ... 31, 2016 , ... St. Joseph Medical Center (SJMC) announced ... which enables physicians at SJMC’s two hospital campuses, downtown and in the Heights, ... the exchange. SJMC’s membership in the health information exchange underscores the hospital’s commitment ...
(Date:5/31/2016)... ... May 31, 2016 , ... The University of Tennessee Medical ... and the latest in Clinical Patient Pod (CPP) technologies provided through ... directly into the clinical workflow. These insights are empowering the more than 30 ...
(Date:5/31/2016)... ... 2016 , ... DDL, Inc. announced today it has expanded the scope of ... ISO 594-1 and ISO 594-2 testing for conical (Luer) fittings. , A conical ... medical devices (e.g. a syringe and hypodermic needle) that carry small volumes of fluids. ...
(Date:5/31/2016)... ... May 31, 2016 , ... Spartan Bioscience today introduced the ... and convenience. , The Cube is exceptionally small—it takes up the space of ... easily into any space, whether in a hospital, doctor’s office, or pharmacy. , ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... 31, 2016 According to a ... (Scanners, Software), by Type (Human, Animal Pathology), by End ... Drug Discovery) - Global Forecasts to 2021", published by ... forecast period of 2016 to 2021. This market is ... USD 384.3 Million in 2016, at a CAGR of ...
(Date:5/31/2016)... 2016   Plexus Technology Group, LLC ... management systems (AIMS), is pleased to announce the ... President of Technology. In this new capacity, Mr. ... the company,s technological development. He will collaborate with ... the expansion of new products, product features and ...
(Date:5/31/2016)... BASEL, Switzerland , May 31, 2016 ... has announced the initiation of a first-in-human clinical trial ... class, fusion molecule - S101 is currently being developed ... phase 1 study is designed to evaluate the safety ... be conducted at several sites across the ...
Breaking Medicine Technology: