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Boston University researchers receive NIH funding for genetic research in Alzheimer's disease
Date:7/8/2014

health and long-term care services for affected individuals across all federal agencies. One of the first projects mandated by NAPA was the Alzheimer's Disease Sequencing Project (ADSP). With this funding, CHARGE becomes a member of the National Institute of Aging-mandated Sequence Analysis Consortium, which also includes three National Human Genome Research Institute (NHGRI) Large-Scale Sequencing Centers.

CHARGE investigators will analyze whole exome and whole genome sequence data generated from 6,000 subjects with Alzheimer's disease and 5,000 elderly individuals who do not have Alzheimer's disease. They also will study data from approximately 100 large families, mostly of Caribbean and Hispanic descent, that include multiple individuals with Alzheimer's disease to identify rare genetic variants that either protect against or cause Alzheimer's disease. They will also be contributing additional CHARGE data from over 11,000 subjects with information on genetic sequence and AD-related traits.

"AD currently has no effective treatment thus prevention is the primary strategy to combat this disease," said Boston University School of Medicine Dean Karen Antman, MD. "This is an exciting opportunity for our faculty to develop novel approaches that might ultimately delay or prevent AD."

CHARGE is a collaboration of an international group of investigators. Eric Boerwinkle, PhD at the University of Texas, Houston and Baylor College of Medicine and Ellen Wijsman, PhD at the University of Washington will lead other funded CHARGE projects. Cornelia van Duijn, PhD who is a consultant on behalf of Erasmus University in the Netherlands.


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Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

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