Navigation Links
Boston University researchers expand synthetic biology's toolkit
Date:8/2/2012

BOSTON (8/2/12) -- Through the assembly of genetic components into "circuits" that perform logical operations in living cells, synthetic biologists aim to artificially empower cells to solve critical problems in medicine, energy and the environment. To succeed, however, they'll need far more reliable genetic components than the small number of "off-the-shelf" bacterial parts now available.

Now a new method developed by Boston University biomedical engineers Ahmad S. Khalil and James J. Collins -- and collaborators at Harvard Medical School, Massachusetts General Hospital and MIT -- could significantly increase the number of genetic components in synthetic biologists' toolkit and, as a result, the size and complexity of the genetic circuits they can build. The development could dramatically enhance their efforts not only to understand how biological organisms behave and develop, but also to reprogram them for a variety of practical applications.

Described in the August 2 online edition of Cell, the method offers a new paradigm for constructing and analyzing genetic circuits in eukaryotes -- or organisms whose cells contain nuclei, which include everything from yeasts to humans. Instead of constructing these circuits with off-the-shelf parts from bacteria and porting them into eukaryotes, as most synthetic biologists do, Khalil and his collaborators have engineered these circuits using modular, functional parts from the eukaryotes themselves.

With funding from the Howard Hughes Medical Institute, the Defense Advanced Research Projects Agency and other sources, the research team built their synthetic genetic circuit parts from a class of proteins, known as zinc fingers, which can be programmed to bind desired DNA sequences. The modularity of the new parts enables a wide range of functions to be engineered, the construction of much larger and more complex genetic circuits than what's now possible with bacteria-based parts, and ultimately, the
'/>"/>

Contact: Mike Seele
mseele@bu.edu
617-353-9766
Boston University College of Engineering
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Leaders in childrens health to gather in Boston
2. Boston researcher, surgical oncologist receives national award
3. SLEEP 2012 presents latest in sleep medicine and research June 11-13 in Boston
4. Snoring Isn’t Sexy Member, Dr. Mark Levy attends the American Academy of Dental Sleep Medicine Meeting in Boston, MA
5. University of Cincinnati researchers win $3.7M grant from US Department of Defense
6. Leading experts on congenital muscular dystrophy convene at University of Nevada, Reno
7. Rice University student engineers automate limb lengthening for kids
8. Louisiana Tech University professor earns NSF Early Career Development grant
9. Neuropsychologist receives University of Houstons highest faculty honor
10. University of Houston Graduate College of Social Work announces partnership with MD Anderson
11. Columbia University Medical Center and NY-Presbyterian experts at APA meeting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Boston University researchers expand synthetic biology's toolkit
(Date:12/17/2014)... Unidesk Corporation today announced that the ... its inaugural class in August 2013, has successfully ... bring your own device (BYOD) and deliver a ... solution, comprised of Citrix XenDesktop and ... storage infrastructure and Unidesk virtual desktop ...
(Date:12/17/2014)... December 17, 2014 HeartMath® Inc., ... on stress, heart rate variability (HRV), heart coherence ... its extensive HRV databases and algorithms to chipset ... will enable HeartMath’s partners to offer its HRV ... research, as well as its normative HRV databases ...
(Date:12/17/2014)... Appleton, WI (PRWEB) December 17, 2014 ... Benefit Administrators and its Argus Claim Review division ... two of the most common ways savings are achieved ... administrator (TPA) attributes millions of dollars in savings to ... saved in 2013. , As explained by Tom Doney, ...
(Date:12/17/2014)... 17, 2014 Now in its second ... best of the best in senior living and home ... given to communities and agencies that have received outstanding ... Of the nearly 100,000 providers currently listed on SeniorAdvisor.com, ... the SeniorAdvisor.com Best of 2015 Awards are located all ...
(Date:12/17/2014)... gas prices rose in recent years, so did motorcyclist ... times of gas increases, more people start using motorcycles ... explained. They examined data gathered between 2002 and ... motorcycle registrations in the United States and the third ... a strong association between rising gas prices and an ...
Breaking Medicine News(10 mins):Health News:Alabama College of Osteopathic Medicine Deploys Desktop Virtualization Solution from Citrix, Dell and Unidesk 2Health News:Alabama College of Osteopathic Medicine Deploys Desktop Virtualization Solution from Citrix, Dell and Unidesk 3Health News:HeartMath® Inc.’s HRV Platform Solutions Available for Licensing 2Health News:HeartMath® Inc.’s HRV Platform Solutions Available for Licensing 3Health News:Out-of-Network & Medical Necessity Reviews among Top Ways TPA Identifies Significant Medical Claim Savings 2Health News:The Inn at Willow Falls - Crest Hill, IL Wins 2015 Best of Assisted Living Award from SeniorAdvisor.com 2Health News:The Inn at Willow Falls - Crest Hill, IL Wins 2015 Best of Assisted Living Award from SeniorAdvisor.com 3Health News:When Gas Prices Go Up, So Do Motorcycle Accidents, Study Finds 2
... and Forests has called for an action plan and ... National Workshop// on ‘Human - Leopard Conflict Management’ here ... need to have a re-look at our existing strategies ... one of the challenging issues facing wildlife managers in ...
... Assistant Professor Biswarup Mukhopadhyay has provided important information ... in the// December 22, 2006, Journal of Biological ... help researchers to identify potential targets for docking ... eliminate, the body's overproduction of glucose. ...
... viral culture system, which makes way for a better ... replication of virus// (isolated from patient) in non-transformed hepatocytes. ... in transformed cell lines. ,The study report ... transfected and serum-infected cultured human fetal hepatocytes,’ appears in ...
... novel analysis about the usage of cholesterol lowering drugs ... drug as a means to prevent heart disease; Researchers ... to lower life-threatening health risks for those suffering vascular ... beneficial in reducing the risk of heart attack and ...
... weapon in the war on cancer by targeting the human ... ,Two separate teams of researchers have found a ... that would otherwise stimulate the spread of the cancer. Although ... describing the approach as potentially one of the most important ...
... and Drug Administration has found that meat or milk from ... clones—is as safe to eat as food from// conventionally bred ... three documents regarding the safety of animal cloning—a draft risk ... for industry. ,Dr. Stephen F. Sundlof, director of ...
Cached Medicine News:Health News:VBI Provides Potential Targets to Diabetes Therapeutics 2Health News:A Breakthrough in the Study of Hepatitis C 2Health News:Cancer Scientists' Gene Research Offers New Treatment Hope 2Health News:FDA Finds Animal Cloned Food to Be Safe 2
(Date:12/15/2014)... , December 15, 2014 ... Am 19. und 20. Februar sind alle ... SAFE MEDICINE ECOSYSTEM PARTNER PROGRAMM ™ 2015 ... besuchen. Diese Tagung soll dazu ... Möglichkeit geben, die neue profitablen Unternehmensdienstleistungen, die ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/ms3j8c/cardiac ) has announced the addition ... and Forecasts, 2012-2018"  report to their offering. Global ... 2016. The North America accounts ... Europe claims approximately 25% (2018). ...
(Date:12/15/2014)... BRIDGEWATER, N.J. , Dec. 15, 2014   ... SAN and NYSE: SNY) are collaborating with nationally-recognized patient ... Counts , an awareness program that will gauge how ... risks associated with high LDL-C (bad cholesterol).  American adults ... to take a brief poll and answer a few ...
Breaking Medicine Technology:Symposium über Aegates Ecosystem-Partner-Programm für sichere Medikamente vom 19. - 20. Februar 2015 in Amsterdam 2Cardiac Guidewires - Global Trends, Estimates and Forecasts, 2012-2018 2Cardiac Guidewires - Global Trends, Estimates and Forecasts, 2012-2018 3Cardiac Guidewires - Global Trends, Estimates and Forecasts, 2012-2018 4Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 2Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 3Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 4Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 5Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 6
... the understanding of and possible ... ageing and cancer, BILLERICA, Mass., Oct. 6 ... analytical instrument for the,kinetic measurement of mitochondrial oxygen consumption ... For the past 75 years tools,for measuring cellular bioenergetics ...
... ... studies, ... research in children saves lives and improves their,health and well-being. A ... Clinical Studies", (http://www.ChildrenAndClinicalStudies.nhlbi.nih.gov ), offers parents and health,care providers an insider,s ...
Cached Medicine Technology:Seahorse Bioscience Announces the XF96 Extracellular Flux Analyzer for Cellular Bioenergetics 2Seahorse Bioscience Announces the XF96 Extracellular Flux Analyzer for Cellular Bioenergetics 3Photos: NIH Launches New Web Site for Parents on Medical Research Studies for Children 2Photos: NIH Launches New Web Site for Parents on Medical Research Studies for Children 3Photos: NIH Launches New Web Site for Parents on Medical Research Studies for Children 4
Used to occupy an empty hole which is not being used in an implantablepacemaker header....
Implantable medical grade silicone sleeve for adapting a 5 mm (01) connector to a 6 mm (02) connector....
Implantable medical grade silicone end cap for insulation and sealing protection of 5 mm or 3.2 mm connectors....
... Tupos LA, the only ICD system in ... the first implant for the treatment of ... a lasting improvement of their hemodynamics and ... LA uses biatrial stimulation to effectively suppress ...
Medicine Products: