Navigation Links
Boston University researchers and collaborators receive $12.6 million NIH grant for AD
Date:7/7/2014

Boston - Researchers from the Biomedical Genetics division of the Boston University School of Medicine (BUSM) are part of a five-university collaboration receiving a $12.6 million, four-year grant from the National Institute on Aging (NIA), part of the National Institutes of Health (NIH), to identify rare genetic variants that may either protect against, or contribute to Alzheimer's disease risk.

At BUSM, the Consortium for Alzheimer's Sequence Analysis (CASA) is led by Lindsay A. Farrer, PhD, Chief of Biomedical Genetics and professor of medicine, neurology, ophthalmology, epidemiology, and biostatistics, who is the principal investigator. Other Boston University investigators include Kathryn Lunetta, PhD, professor of biostatistics; Gyungah Jun, PhD, assistant professor of medicine, ophthalmology and biostatistics; and Richard Sherva, PhD, research assistant professor of medicine.

CASA investigators will analyze whole exome and whole genome sequence data generated during the first phase of the NIH Alzheimer's Disease Sequencing Program, an innovative collaboration that began in 2012 between NIA and the National Human Genome Research Institute (NHGRI), also part of NIH. They will analyze data from 6,000 volunteers with Alzheimer's disease and 5,000 older individuals who do not have the disease. In addition, they will study genomic data from 111 large families with multiple members who have Alzheimer's disease, mostly of Caucasian and Caribbean Hispanic descent to identify rare genetic variants.

"This is an exciting opportunity to apply new genomic technologies and computational methods to improve our understanding of the biological pathways underlying this disease," said Farrer. "The genes and pathways we identify as integral to the Alzheimer process may become novel therapeutic targets," he added.

Alzheimer's disease, a progressive neurodegenerative disorder, has become an epidemic that currently affects as many as five million people age 65 and older in the United States, with economic costs that are comparable to, if not greater than, caring for those of heart disease or cancer. Available drugs only marginally affect disease severity and progression. While there is no way to prevent this disease, the discovery of genetic risk factors for Alzheimer's is bringing researchers closer to learning how the genes work together and may help identify the most effective interventions.

This effort is critical to accomplishing the genetic research goals outlined in the National Plan to Address Alzheimer's Disease, first announced by the U.S. Department of Health and Human Services in May 2012 and updated annually. Developed under the National Alzheimer's Project Act, the plan provides a framework for a coordinated and concentrated effort in research, care, and services for Alzheimer's and related dementias. Its primary research goal is to prevent and effectively treat Alzheimer's disease by 2025.

With the current award, CASA joins the NHGRI Large-Scale Sequencing and Analysis Centers program, an NIH-supported consortium that provides large-scale sequence datasets and analysis to the biomedical community. CASA researchers will facilitate the analyses of all Alzheimer's Disease Sequencing Project (ADSP) and additional non-ADSP sequence data to detect protective and risk variants for Alzheimer's disease.

"We are delighted to support the important research being accomplished under this broad-based, collaborative effort. A team effort is vital to advancing a deeper understanding of the genetic variants involved in this complex and devastating disease and to the shared goal of finding targets for effective interventions," said NIH Director Francis Collins, MD, PhD.

"Alzheimer's disease research is appropriately one of our highest priorities," said BUSM Dean Karen Antman, MD "We need more to better understand the genetic and environmental mechanisms that will come in part from CASA to develop more effective treatments or even better, to prevent the disease," she added.


'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. Boston Medical Center cardiologist Gary Balady, M.D., receives AHAs Paul Dudley White Award
2. American Society for Microbiology to host 114th General Meeting in Boston
3. Visage Sculpture, Premiere Cosmetic Clinic of Boston, Now Offers Botox and Dysport to Treat Migraines
4. Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Issuance of New Order Pertaining to Discovery in Federal Boston Scientific Litigation
5. Hyatt Regency Boston Hotel's Room for Hope Raises $25,000 to Benefit Boston Children's Hospital
6. World T.E.A.M. Sports Sponsor of December 21 Boston Celtics Experience
7. The Book of Mormon Ticket Prices Slashed in New York, Los Angeles, Las Vegas, Boston, Fort Lauderdale, San Francisco, Charlotte, Cincinnati, Atlanta and Philadelphia
8. Transvaginal Mesh Lawsuits Move Forward, As Bernstein Liebhard LLP Notes New Order in Federal Boston Scientific Litigation
9. “Art In Recycling” Exhibit Opens at Boston Children’s Museum
10. Pwnie Express Announces Headquarters Move to Boston, Massachusetts
11. Boston Children’s Museum and Fathers’ Uplift Announce Pilot Program
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... ... 28, 2016 , ... Greener Hydroponics is now offering a large selection of ... professional organic farmers and nurseries according to Sales Manager Joe Steele who says, “Now ... goal is to offer wholesale level pricing and ultra-fast shipping for growers of any ...
(Date:4/28/2016)... ... April 28, 2016 , ... In 2011, TIME magazine named Herr ... field of biomechatronics, technology that marries human physiology with electromechanics. He continues that work ... also the Founder of BionX , a leader in the field of prosthetic ...
(Date:4/28/2016)... (PRWEB) , ... April 28, ... ... leading provider of enterprise Data Center Infrastructure Management solutions, announces today the ... on feature enhancements in the area of capacity management and optimization, providing ...
(Date:4/28/2016)... , ... April 28, 2016 , ... One way to ... anything.” This is unfortunately true. But we toss the baby out with the bathwater ... brief provides tips for identifying higher-quality studies and otherwise making better use of education ...
(Date:4/28/2016)... , ... April 28, 2016 , ... USA Medical Card reminds us that May is ... a stroke is the fourth leading cause of death in the United States; someone has ... a quarter of them in individuals under 65 years old. A stroke is when ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... , April 27, 2016 ... ), a developer of a new generation of ... positive overall survival results for Paclical/Apealea in the ... 789 patients with epithelial ovarian cancer. These preliminary ... Paclical/Apealea in combination with carboplatin versus Taxol in ...
(Date:4/27/2016)... April 27, 2016 At the ... launch of a Phase 2 clinical study of its ... patients undergoing cochlear implantation (CI) surgery. This large, placebo-controlled, ... Germany and France ... ear at the time of surgery. "Despite advances in ...
(Date:4/26/2016)... CLEVELAND , April 26, 2016 ... is forecast to expand 4.9 percent annually to ... and other healthcare facilities to decrease rates of ... infection prevention supplies, equipment, and services.  Although declining, ... is significantly above targeted levels set by the ...
Breaking Medicine Technology: