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Boston University research suggests new pathways for cancer progression
Date:2/9/2012

BOSTON (2-8-12) Observing that certain cancer cells may exhibit greater flexibility than normal cells, some scientists believe that this capability promotes rapid tumor growth. Now computer simulations developed by Boston University Biomedical Engineering Assistant Professor Muhammad Zaman and collaborators at the University of Texas at Austin appear to support this view. A 3D model of healthy and cancer cells that they've created indicates that the softening of cancer cells not only accelerates their proliferation but also extends their lifetimea one-two punch that may trigger the rapid growth of malignant tumors.

The team's simulations and findings herald a new, quantitative approach to understanding tumor development centered on a small number of mechanical properties rather than multiple biochemical factors.

"Our study is unique in that it takes into account in vivo data on the mechanical properties of cancer cells," said Zaman. "Our novel computer simulation provides a platform to examine how stiffness of cancer cells influences their growth, and could lead to the development of early interventions."

Combining Zaman's expertise in cancer and cell migration with UT-Austin Chemical Engineering Professor Roger Bonnecaze's knowledge of fluid mechanics and postdoctoral fellow Parag Katira's computer simulation skills, the researchers produced a 3D computer model that systematically traces the impact of cell softness and other mechanical factors on cell behavior within a tissue. The model represents each cell as a liquid core encased by a spherical, viscous, elastic shell that can bind or stick to other cells to form a tissue-like mass. In simulations, individual cells are programmed to live, die or divide based on a set of rules drawn from real-time, in vivo experiments with tumor cells.

To emulate tumor growth, the researchers established a baseline simulation of tissue composed exclusively of hard-shelled, healt
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Contact: Mike Seele
mseele@bu.edu
617-353-9766
Boston University College of Engineering
Source:Eurekalert  

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