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Boston Medical Center/Boston University School of Medicine researcher receives award
Date:5/7/2008

cells that, like pancreatic islet-beta cells, will produce insulin in response to food ingestion. Using endoscopy, he plans to introduce transformed cells into the intestinal lining, where they will be programmed to become K-cells and produce insulin as well as GIP. The relocation of insulin production to the upper small intestine will hide it from the autoimmune response that destroys beta-cells in type 1 diabetes. Moreover, because K- and beta-cells are functionally similar, the K-cell appears to represent the ideal candidate for hosting the foreign insulin gene.

Wolfe is recognized as one of the worlds leading authorities on GIP, and he initially cloned the GIP cDNA and ascertained its central role as principal mediator of the enteroinsular axis. This axis functions as the hormonal connection between the intestine and pancreas following the ingestion of food. He established GIP as the likely mediator of the glycemic index and has theorized that low carbohydrate diets and gastric bypass surgery mediate their beneficial effects in part by suppressing GIP expression. He proved its importance in obesity by demonstrating functional receptors on adipocytes and by showing that GIP, like insulin, suppresses the breakdown of fat, which in essence results in an increase in fat storage.

Boston University is delighted to have been invited by The Hartwell Foundation to participate in this years competition and is deeply proud of Dr. Wolfes selection for this exceptionally competitive Individual Biomedical Research Award, said Karen Antman, MD, dean of Boston University School of Medicine and provost of Boston University Medical Campus. The award provides strategic funding for remarkably original research that combines genetic engineering, stem cell therapeutics, and gastroenterology, with exciting potential clinical implications. Private funding is vital to advancing such high-risk, high-gain work, and we are very grateful to The Hartwell Foundation fo
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Contact: Michelle Roberts
michelle.roberts@bmc.org
617-638-8491
Boston University
Source:Eurekalert

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