Navigation Links
Boston Medical Center/Boston University School of Medicine researcher receives award
Date:5/7/2008

Boston, MAM. Michael Wolfe, M.D., professor of medicine and research professor of physiology and biophysics at Boston University School of Medicine and chief of the Gastroenterology Section at Boston Medical Center, was awarded an Individual Biomedical Research Award by The Hartwell Foundation. Wolfe, considered a premier authority on the biology of GI regulatory peptides, will receive $300,000 direct cost over three years as a Hartwell Investigator for his project, Peptide Replacement Therapy Using Transgenic Stem Cells Delivered to the Small Intestinal Mucosa.

Wolfe and his colleagues are developing a technique to redress hormone and enzyme deficiencies that cause diseases such as type 1 diabetes. The technique relies on engineering stem cells that produce the missing peptides and implanting them in the small intestine.

Because of their molecular size and susceptibility to degradation by stomach acid and digestive enzymes, insulin and other hormones must currently be administered by injection. The discomfort and inconvenience associated with injections often diminish patient compliance, particularly in children, which increases the risk of long-term complications. This concern is of particular importance for patients with type 1 diabetes, who often require multiple daily insulin injections to maintain stable blood sugar. Type I diabetes is one of the most common severe chronic diseases in children (1/300 in the US) and a major cause of end-stage renal disease, blindness, cardiovascular disease and premature death in the general population.

In a manuscript published in Science in 2000, Wolfe and his collaborators reported that intestinal K-cells of transgenic mice, which normally manufacture a hormone called GIP, could be engineered to express insulin and maintain normal blood glucose levels, even after pancreatic insulin-producing (islet-beta) cells were destroyed. Employing the same genetic approach, Wolfe plans to transform stem
'/>"/>

Contact: Michelle Roberts
michelle.roberts@bmc.org
617-638-8491
Boston University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Boston Micromachines Multi-DM Named One of the Years Most Innovative Products
2. Boston University School of Medicine researcher recipient of Memory Ride Grant
3. Success of Shape-Up Somerville Childhood Obesity Intervention to be Presented at the Friedman School Symposium at Tufts, October 29-31, 2007 - Boston
4. AAHFNs 2008 Annual Meeting in Boston Will Be Raising the Bar in Heart Failure Care
5. Families Invited to Celebrate Shire Day at Boston Childrens Museum
6. Boston Scientific Announces New Initiatives to Increase Shareholder Value
7. Boston Scientific Announces Additions to Clinical Sciences Organization
8. Boston University School of Medicine physician receives award from AATOD
9. Boston Scientific Announces Verdict in Cordis Litigation
10. Boston Scientific Announces Sale of Cardiac Surgery and Vascular Surgery Businesses
11. Boston Scientific and GE Healthcare Announce their First Patient Data Link to Electronic Medical Record
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2008)...esults of a 10-year study published in the August ...found that magnesium sulfate administered to women...he risk of cerebral palsy by 50 percent. The Benef...) trial was conducted in 18 centers in the U.S., i...renatal intervention ever found to reduce the inst...
(Date:8/29/2008)... http://www.aronowitzmd.com [Los An...espected experience in plastic surgery procedures ...consideration may be necessary for these patients,...e an established specialty of procedures for after...es, CA (PRWEB) August 29, 2008 -- Bariatric surger...
(Date:8/28/2008)...ues increase 138% versus Q2 2007 - Nine new Cen...RNewswire-FirstCall/ - CRH Medical Corporation,(CR... three and six months,ended June 30, 2008 (all fig...ths ended June 30, 2008 increased 138% to $1,653,8...7. Revenue for the six months ended June,30, 2008 ...
(Date:8/28/2008)...ion will be based in the Northeast region with mor...xt year, HARRISBURG, Pa., Aug. 28 /PRNewswire-USN...ity has hired a Patient Safety Liaison for the,Nor...eport to the,Pennsylvania Patient Safety Reporting...ylvania citizens., "Last year in focus groups wit...
Breaking Medicine News(10 mins):Health News:National study shows magensium sulfate reduces risk of cerebral palsy in premature births 2Health News:Dr. Joel Aronowitz, Specialist in Los Angeles Body Lift, Announces Plastic Surgery Options After Bariatric Surgery Weight Loss 2Health News:Dr. Joel Aronowitz, Specialist in Los Angeles Body Lift, Announces Plastic Surgery Options After Bariatric Surgery Weight Loss 3Health News:Dr. Joel Aronowitz, Specialist in Los Angeles Body Lift, Announces Plastic Surgery Options After Bariatric Surgery Weight Loss 4Health News:CRH Medical reports Q2 2008 results 2Health News:CRH Medical reports Q2 2008 results 3Health News:CRH Medical reports Q2 2008 results 4Health News:CRH Medical reports Q2 2008 results 5Health News:Pennsylvania Patient Safety Authority Hires Patient Safety Liaison to Help Healthcare Facilities Implement Guidance 2Health News:Pennsylvania Patient Safety Authority Hires Patient Safety Liaison to Help Healthcare Facilities Implement Guidance 3
...s physically demanding - or who do shift work - co... A major study in the US showed that this heavy wo...ood pressure and underweight babies. Jobs which i...shift work and fatiguing work were also significan...
...the triptans are known to help counter the unpleas...re seven different triptan drugs available, it is ... the University of Netherlands have carried out a...on the triptans, covering over 18,000 patients. Th...
...it shows that warfarin and aspirin are equally eff...ients at risk. Aspirin prevents blood clotting by ...arfarin acts on the levels of blood clotting prote...s in the brain that lead to strokes. Till date, it...
...smallpox vaccine is being tested against cervical ...with 95% of cervical cancer cases, but not everyon...cer affects about 465,000 women worldwide each yea...d treated in its earliest stages there is a high s...
Other Medicine News:
(Date:8/27/2008)...Parts of Bucks, Delaware, Montgomery,Philadelphia...SNewswire/ -- After encouraging,results following ...nt of,Environmental Protection will continue its e...the mosquito-borne West Nile virus., Targeted aer... and,midnight in portions of Bucks, Delaware, Mont...
(Date:8/27/2008)...c Heart Center at The Children,s Hospital at, Mo... Range of Care and Speci...ogy Team Treats Every Heart Condition, NEW YORK, ...Hospital at,Montefiore (CHAM) is bringing the medi...the Bronx, following the recent approval of its,tr...
(Date:8/26/2008)...wswire/ -- Semafore Pharmaceuticals Inc.,presented...geted Therapies,in Cancer in Washington, D.C., ann...se inhibitors that demonstrate significant antican... proprietary molecular scaffold has been developed...ign of pan-PI3 kinase inhibitors,as well as isofor...
(Date:8/26/2008)...nnovative Manufacturing - Has Potential to ..., ROCKVILLE, Md., Aug. 26 /PRNewswire-FirstCall/ ...favorable results from the second stage of,the Pha...uenza virus-like,particle (VLP) vaccine candidate....induced robust neutralizing antibody responses. No...
Breaking Medicine Technology:DEP to Complete Aerial Mosquito Treatments to Stem West Nile Virus in Southeastern Counties 2DEP to Complete Aerial Mosquito Treatments to Stem West Nile Virus in Southeastern Counties 3Pediatric Heart Transplants at Montefiore Approved by NY State Department of Health 2Pediatric Heart Transplants at Montefiore Approved by NY State Department of Health 3Pediatric Heart Transplants at Montefiore Approved by NY State Department of Health 4Semafore Broadens Pipeline With Multi-Targeted Kinase Inhibitors 2Semafore Broadens Pipeline With Multi-Targeted Kinase Inhibitors 3Novavax Announces Favorable Results from Phase I/IIa Pandemic Influenza Vaccine Program 2Novavax Announces Favorable Results from Phase I/IIa Pandemic Influenza Vaccine Program 3Novavax Announces Favorable Results from Phase I/IIa Pandemic Influenza Vaccine Program 4Novavax Announces Favorable Results from Phase I/IIa Pandemic Influenza Vaccine Program 5Novavax Announces Favorable Results from Phase I/IIa Pandemic Influenza Vaccine Program 6Brookdale Announces First Quarter 2008 Results 18721 1Brookdale Announces First Quarter 2008 Results 18721 2Brookdale Announces First Quarter 2008 Results 18721 3Brookdale Announces First Quarter 2008 Results 18721 4Brookdale Announces First Quarter 2008 Results 18721 5Brookdale Announces First Quarter 2008 Results 18721 6Brookdale Announces First Quarter 2008 Results 18721 7Brookdale Announces First Quarter 2008 Results 18721 8Brookdale Announces First Quarter 2008 Results 18721 9Brookdale Announces First Quarter 2008 Results 18721 10Brookdale Announces First Quarter 2008 Results 18721 11Brookdale Announces First Quarter 2008 Results 18721 12Brookdale Announces First Quarter 2008 Results 18721 13Brookdale Announces First Quarter 2008 Results 18721 14Brookdale Announces First Quarter 2008 Results 18721 15Brookdale Announces First Quarter 2008 Results 18721 16Brookdale Announces First Quarter 2008 Results 18721 17Brookdale Announces First Quarter 2008 Results 18721 18Brookdale Announces First Quarter 2008 Results 18721 19Brookdale Announces First Quarter 2008 Results 18721 20Brookdale Announces First Quarter 2008 Results 18721 21Brookdale Announces First Quarter 2008 Results 18721 22FDA Advisory Committee Votes in Favor of Approval of Fospropofol Disodium Injection for Sedation 5200 1FDA Advisory Committee Votes in Favor of Approval of Fospropofol Disodium Injection for Sedation 5200 2FDA Advisory Committee Votes in Favor of Approval of Fospropofol Disodium Injection for Sedation 5200 3UCSF receives funding for building from California stem cell agency 18718 1UCSF receives funding for building from California stem cell agency 18718 2UCSF receives funding for building from California stem cell agency 18718 3The FAQs about the human genome 3230 1
...lls Isolated from Females Regenerate Skeletal Musc...pril 09, 2007 /PRNewswire/ -- Female stem cells,de...rate skeletal,muscle tissue than male cells, accor...gh of UPMC. , The study, which is being published ...y, is the first ever to report a difference,in reg...
...y and MedImmune to Present Preclinical Data From S...IDGE, Mass. and GAITHERSBURG, Md., April 10, 2007 ... (Nasdaq:INFI) and,MedImmune, Inc. (Nasdaq:MEDI) t...with an oral formulation of IPI-504 in non-small,c...pcoming Annual,Meeting of the American Association...
Other Medicine Technology:The Sturdier Sex?: Study by Pittsburgh Scientists Finds Female Stem,Cells Work Better 2The Sturdier Sex?: Study by Pittsburgh Scientists Finds Female Stem,Cells Work Better 3Infinity and MedImmune to Present Preclinical Data From Study of,Oral Formulation of IPI-504 At AACR 2Infinity and MedImmune to Present Preclinical Data From Study of,Oral Formulation of IPI-504 At AACR 3Infinity and MedImmune to Present Preclinical Data From Study of,Oral Formulation of IPI-504 At AACR 4
Bulb Direct has been selling replacement bulbs on the Internet since 1996, and we are extremely proud of our 100% satisfaction guarantee. Check out our catalog of replacement bulbs and see our discou
...clusive Measuring System delivers precise and accu...eel they are receiving a better examination when t...ipment. ,User Friendly - after only 5 minutes of...ome very proficient in the operation of this instr...
.90mm (20G) guillotine cutting probe with 1.4mm (17G) removable irrigation sleeve
Sleeve extends 3mm beyond end, .90mm (20G) probe, 1.4mm (17G) sleeve
Medicine Products: