Navigation Links
Boston College researcher looks to stop a deadly parasite in its tracks

CHESTNUT HILL, MA (December 10, 2012) The American Cancer Society has awarded a four-year, $720,000 grant to Boston College Associate Professor of Biology Marc-Jan Gubbels for research into potential new drugs that can prevent the onset of toxoplasmosis in cancer patients with weakened immune systems.

The parasite Toxoplasma gondii has infected one out of every five people in the U.S., typically remaining dormant in healthy individuals. But when the immune system is weakened, the parasite attacks, wreaking havoc on the patient's body and often causing death.

Gubbels, who specializes in parasitology, said he's grateful for the opportunity to advance Toxoplasma gondii research as a means of improving the health of individuals at risk for toxoplasmosis.

"The American Cancer Society has given us a unique opportunity to take a new approach toward identifying potential targets to combat a deadly disease," said Gubbels. "This is a novel approach and we're excited to move forward with our work."

Among those most at risk for the stealthy killer toxoplasmosis are cancer patients whose immune systems are compromised during chemotherapy and other treatments that weaken the body's defenses. While there are drugs that can help hold the illness in check, they produce unwanted side effects in some patients and also inhibit the effectiveness of some anti-cancer drugs.

Gubbels, whose work has helped to unlock some of the genetic mysteries of Toxoplasma gondii, is researching new ways to prevent the spread of the parasite by limiting its mobility and effectively trapping it within the cells where it attacks.

The American Cancer Society grant will support work by the Gubbels' lab that could lead to the development of new drugs that can prevent the parasite from attacking its unsuspecting hosts. Patients battling cancer are particularly vulnerable when potent anti-cancer treatments weaken their immune systems.

"We're trying to find out how this parasite gets in or out of a cell," said Gubbels. "Cells in our bodies don't invade other cells, but Toxoplasma gondii cells have dedicated machinery to do that. We have a basic understanding of this, but we don't know how it all fits together or is controlled. If we can understand that process, we can design drugs that can counteract that and hopefully save lives."

Toxoplasma gondii is carried by almost every warm-blooded animal and is spread through ingesting cysts present in undercooked meat or in cat feces. An intra-cellular parasite that lives within the cells of its host, the parasite must first enter a cell and then, after consuming its contents, exit the cell. Gubbels and researchers in his lab are looking for ways to control entry and exit by turning off genes that inform the parasite's mobility.

Invasion and egress share many features, Gubbels added. But they are poorly understood at the molecular level. In addition, current anti-toxoplasmosis drugs do not target either invasion or egress.

The Gubbels research team will take normal strains of the parasite and then create gene mutations within them. After singling out the altered parasites, researchers will determine whether the genes involved play a role in the parasite's entrance to or exit from a host cell. Gubbels said the goal is to find proteins with essential functions in a defining pathogenic process not targeted by current drugs.

"The overarching goal of our work is to increase the number of treatment options for toxoplasmosis, in particular to develop drugs with fewer side effects," Gubbels said. "The best drug targets are found in biological processes that the parasite does not share with the host. The process we are interested in is the process of how the parasite gains access to the cells of the host, and subsequently, how it is able to escape from the host cell upon completion of replication."

Advances in cellular biology and genome sequencing have paved the way for this type of project, Gubbels said. Armed with these tools, researchers can make more focused inquiries into the functions those genes control.

Toxoplasma gondii has steadily grown as a research priority since the 1960s, when it was discovered that cats host the parasite in its reproductive stage. Pregnant women are urged to avoid close contact with cats and cat feces during pregnancy, since toxoplasmosis can cause birth defects. During the onset of the AIDS crisis in the 1980s, toxoplasmosis claimed many victims whose immune systems were compromised by the virus, Gubbels said. The decoding of the parasite's genome within the past decade has further advanced research into a largely unseen killer.


Contact: Ed Hayward
Boston College

Related medicine news :

1. Leaders in childrens health to gather in Boston
2. Boston researcher, surgical oncologist receives national award
3. SLEEP 2012 presents latest in sleep medicine and research June 11-13 in Boston
4. Snoring Isn’t Sexy Member, Dr. Mark Levy attends the American Academy of Dental Sleep Medicine Meeting in Boston, MA
5. Boston University researchers expand synthetic biologys toolkit
6. Cincinnati and Boston Childrens Hospitals receive an NIH Autism Center of Excellence Grant
7. Boston Medical Center awarded elite distinction as a 2012 Leapfrog Top Hospital
8. Weill Cornell Medical College establishes Center for Healthcare Informatics and Policy
9. Texting in College Classrooms Common, Distracting
10. Overuse Injuries Common Among Female College Athletes
11. American College of Cardiology cites new USF Simulation Center for Training Excellence
Post Your Comments:
(Date:11/27/2015)... , ... November 27, 2015 , ... ... the health care in America. As people age, more care is needed, especially ... are rising, and medical professionals are being overworked. The forgotten part of this ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... the November 27th edition of USA Today in Atlanta, Dallas, New York, Minneapolis, ... of 750,000. The digital component is distributed nationally, through a vast social media ...
(Date:11/27/2015)... ... 27, 2015 , ... A simply groundbreaking television series, "Voices in America", which ... into an array of issues that are presently affecting Americans. Dedicated to providing the ... show is changing the subjects consumers focus on, one episode at a time. ...
(Date:11/27/2015)... CA (PRWEB) , ... November 27, 2015 , ... ... California Medical Associates, Inc. and Dr. Tucker Bierbaum with Emergency Medicine at ... They observed that both STEMI and Sepsis conditions present in similar ways and require ...
(Date:11/26/2015)... ON (PRWEB) , ... November 26, 2015 , ... ... of a real-time eReferral system for diagnostic imaging in the Waterloo region. Using ... BMD and Nuclear Medicine tests directly from their electronic medical record (EMR) without ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... 26, 2015 ... the "2016 Global Tumor Marker Testing ... and Sales Segment Forecasts, Innovative Technologies, Instrumentation ... to their offering. --> ... "2016 Global Tumor Marker Testing Market: ...
(Date:11/26/2015)... November 26, 2015 Un nuevo ... Bremachlorin para el cáncer avanzado.   --> ... terapia fotodinámica de Bremachlorin para el cáncer avanzado. ... la inmunoterapia con la terapia fotodinámica de Bremachlorin para ... Research . --> Clinical Cancer Research . ...
(Date:11/26/2015)... 26, 2015 --> ... approach blends immunotherapy with Bremachlorin-photodynamic therapy for advanced cancer. ... blends immunotherapy with Bremachlorin-photodynamic therapy for advanced cancer. ... blends immunotherapy with Bremachlorin-photodynamic therapy for advanced cancer. ... found that immunotherapy can be efficiently combined with photodynamic ...
Breaking Medicine Technology: