Navigation Links
Boston College biologists build a better mouse model for cancer research
Date:4/9/2008

CHESTNUT HILL, MA (4/9/08) Researchers at Boston College have developed the first laboratory mouse model that mimics cancers spread through the human body. Using their novel cell line, the team discovered one of the bodys primary defensive cells plays a role in cancers attack.

The development of a new animal model a line of cancer cells injected into a laboratory mouse that displays the full spectrum of systemic metastatic cancer in humans removes a "scientific stumbling block" in advancing cancer research and potential treatments, according to Boston College Biologist Thomas Seyfried, whose findings appear this week in the online version of the International Journal of Cancer and will be presented at the annual meeting of the American Association of Cancer Research in San Diego.

"What we have developed is the first model in the mouse that replicates all of the hallmarks of metastatic cancer," said Seyfried, the project leader. Now, we have a tool that can be effective in identifying basic mechanisms and new therapies to treat the disease.

Researchers produced two cell lines that when injected into mice express all the major biological processes of metastasis. A third line, when injected, grew rapidly, but did not lead to metastatic cancer.

Previous mouse models contain limitations in effectiveness and speed. Many models fail to produce cancer in each animal subject and it often takes several months before cancer is detected. In other models, cancer cells are transplanted into animals with disabled immune systems. Within three weeks, the two Seyfried models produced tumors in 100 percent of the mice, which had healthy immune systems.

The cell line enabled researchers to make a new discovery about metastatic cells, namely that these cells express properties of macrophages, tissue cells that usually protect organisms against invading microbes in the environment and bacteria that lead to infection and disease.

<
'/>"/>
Contact: Ed Hayward
ed.hayward@bc.edu
617-552-4826
Boston College
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Boston Micromachines Multi-DM Named One of the Years Most Innovative Products
2. Boston University School of Medicine researcher recipient of Memory Ride Grant
3. Success of Shape-Up Somerville Childhood Obesity Intervention to be Presented at the Friedman School Symposium at Tufts, October 29-31, 2007 - Boston
4. AAHFNs 2008 Annual Meeting in Boston Will Be Raising the Bar in Heart Failure Care
5. Families Invited to Celebrate Shire Day at Boston Childrens Museum
6. Boston Scientific Announces New Initiatives to Increase Shareholder Value
7. Boston Scientific Announces Additions to Clinical Sciences Organization
8. Boston University School of Medicine physician receives award from AATOD
9. Boston Scientific Announces Verdict in Cordis Litigation
10. Boston Scientific Announces Sale of Cardiac Surgery and Vascular Surgery Businesses
11. Boston Scientific and GE Healthcare Announce their First Patient Data Link to Electronic Medical Record
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... Lewisberry, PA (PRWEB) May 06, 2015 A quality ... option for a functional yet practical way to raise chickens on ... coop by Chicken Coop Condo, it will have a chicken tractor ... It will last for many years, as it is able to ... help control which areas of the land are fertilized, and it ...
(Date:5/6/2015)... May 06, 2015 Corporate Executives ... of MEBC, an Alliance Award for excellence in ... FOCUS 2015, JDA’s annual user conference which brought ... and wholesale distribution sectors. This award recognizes MEBC, ... receiving services that advance their supply chain performance ...
(Date:5/6/2015)... Prime Pacific Health Innovations, the ... announce a new series of universal, one-time-use speculum ... footprint while improving treatment efficacy and saving therapists ... the world’s first waste hose designed specifically for ... claims the company’s president, Mr. Delmar Vogel. , ...
(Date:5/6/2015)... King of Prussia, PA (PRWEB) May 06, 2015 ... Business Process Outsourcing solutions to the Medicare Advantage, Medicare ... three finalists in the Continuity and Resilience Team category ... by the Business Continuity Institute to recognize the outstanding ... or operating in the North America Region, including the ...
(Date:5/6/2015)... Is Colorado’s legal cannabis industry the victim of ... will mark the 18-month milestone of its historic experiment ... Colorado’s legal marijuana industry has been successful and has ... some new challenges. , For example, many marijuana retailers ... the wake of last month’s “420” cannabis celebrations. And ...
Breaking Medicine News(10 mins):Health News:Chicken Coop Condo Launches the Chicken Tractor 2Health News:MEBC Receives Award for Consulting Excellence in Retail 2Health News:World’s First Compact Colon Hydrotherapy Speculum Kit 2Health News:World’s First Compact Colon Hydrotherapy Speculum Kit 3Health News:TMG Health Recognized by the Business Continuity Institute 2Health News:TMG Health Recognized by the Business Continuity Institute 3Health News:As Colorado Faces Regional Shortages, Cannabis CEO Says Marijuana Will Eventually Be Traded like Any Other Commodity 2Health News:As Colorado Faces Regional Shortages, Cannabis CEO Says Marijuana Will Eventually Be Traded like Any Other Commodity 3
... health as a means to prevent spread of HIV , , ... help prevent AIDS, say Japanese researchers. , The link, they ... found that periodontitis-causing P. gingivalis bacteria can trigger ... that causes AIDS. P. gingivalis is among ...
... clinically proven, extremely effective and safe product for ... was invented by Dr. Hanxian Huang, M.D., Ph.D., ... a unique ginger extract, in combination with vital ... joint cartilage. "This is a very effective natural ...
... 3 In conjunction with its first quarter 2009 earnings release ... Covance Inc. (NYSE: CVD ) is pleased to invite ... be broadcast live over the Internet on Thursday, April 30, 2009 ... Quarter 2009 Earnings Webcast and Slide Presentation, When: ...
... the essential benefits of a full-fledged system without high costs ... ... (Vocus) April 3, 2009 -- iMedica Corporation , a ... today the launch of Transition ™, a new electronic ...
... daughter who knows the struggles of keeping track ... medications, MyMedManager™ is a new comprehensive, healthcare organizer ... their caregivers to keep track of pertinent medical ... spiral binder, MyMedManager™ is the perfect tool for ...
... NEW YORK, April 2 President Obama,s economic stimulus ... healthcare system. For this area of healthcare reform ... technology companies and healthcare providers.See video from Siemens (NYSE: ... http://inr.mediaseed.tv/oneClip_C/?feed=X6fAfAtW_HWQ5S5paXB0nladeaiVEWtF Information technology (IT), ...
Cached Medicine News:Health News:A Clinically Proven, Extremely Effective and Safe Product for Joints Now Available 2Health News:iMedica Launches Transition&#8482;, a New, Streamlined EHR That Breaks Down the Barriers to Physician Adoption and Use 2Health News:iMedica Launches Transition&#8482;, a New, Streamlined EHR That Breaks Down the Barriers to Physician Adoption and Use 3Health News:iMedica Launches Transition&#8482;, a New, Streamlined EHR That Breaks Down the Barriers to Physician Adoption and Use 4Health News:New Medical Organizer Allows People to Easily Manage Their Own Healthcare 2Health News:New Medical Organizer Allows People to Easily Manage Their Own Healthcare 3
(Date:5/6/2015)... , May 6, 2015  LumiThera Inc., a medical ... (PBM) treatment for ocular disorders and disease, today announced ... join LumiThera,s Advisory Board to assist in the company,s ... DeValois "Norm" Dicks was the U.S. Representative for ... 1977 and 2013. He is a member of the ...
(Date:5/6/2015)... 2015 Research and Markets ( ... "Global Insulin Patch Market Opportunity Analysis" ... technology like ultrasound and iontophoresis are being used ... upon the type of technique, their prices may ... several patients. In long-term, it would be considered ...
(Date:5/6/2015)... YORK , May 6, 2015   CEFALY ... electrical nerve stimulation device specifically authorized for use prior ... announce significant breakthroughs in migraine treatment at the EUROHEADPAIN ... in Valencia, Spain , from May ... at a meeting of EUROHEADPAIN, a major European research ...
Breaking Medicine Technology:Retired Congressman Norman Dicks Joins LumiThera's Advisory Team 2Global Insulin Patch Market Opportunity Analysis 2015 2CEFALY to Present Breakthrough Data in Migraine Treatment at International Headache Society Congress 2
... ALLEGAN, Mich., May 10, 2011 Perrigo Company (Nasdaq: ... to settle all Hatch-Waxman litigation relating to fluticasone lotion brought ... relevant patents. Under the terms of the settlement, Perrigo can ... 22, 2012, or earlier under certain circumstances. ...
... Tenn., May 10, 2011 MedQuist Holdings Inc. (NASDAQ: ... transcription services and technology-enabled clinical documentation workflow solutions, today ... St. Joseph,s Hospital Health Center in Syracuse, New York, ... projected to achieve significant cost savings and improve efficiency ...
Cached Medicine Technology:Perrigo Announces Settlement of Cutivate Lotion Litigation 2MedQuist Awarded Clinical Documentation Outsource Contract for St. Joseph's Hospital Health Center With Focus on Cost Savings, Quality, Peace of Mind 2MedQuist Awarded Clinical Documentation Outsource Contract for St. Joseph's Hospital Health Center With Focus on Cost Savings, Quality, Peace of Mind 3
... designed specifically for posteror ... injection of silicone oil ... Special high pressure tubing ... cannula. May also be ...
For surgical treatment, repair and irrigation of the nasolacrimal system. Angled 45 degrees 13mm from end. Stainless steel probes, 20G x 1 3/4in (.90 x 45cm) Silicone rod, length 13 3/4in (40cm), Dia...
IOL choppers for positioning intraocular lenses. Blunt tip avoids damage to intraocular lenses. For .20mm diameter holes and larger....
...
Medicine Products: