Navigation Links
Boring cells could hold the key to heart disease
Date:4/24/2014

Fibroblasts, cells long thought to be boring and irrelevant, could offer an alternative to heart transplants for patients with heart disease.

Researcher Dr Milena Furtado, and her team from the Australian Regenerative Medicine Institute (ARMI) at Monash University, found the heart cell fibroblast is a close relative to a cardiomyocyte, the cell responsible for a healthy beating heart.

In research published today in Circulation Research, Dr Furtado has found that cardiac fibroblasts are unique cells due to their genetic program, and will aid in the development of cell therapies for congenital heart disease and heart failure.

"Heart disease is still one of the major killers in our society and so far no effective therapeutic options are available. Our laboratory aims to understand how the various cell types present in a heart can improve the outcome of heart failure,' Dr Furtado said.

"Fibroblasts were thought to act as a sort of biological glue, making sure that all parts of the body work effectively. We now know they are far more specialised than that and have organ specific functions."

Using cutting edge technology, the team found that cardiac fibroblasts have specific genes called transcription factors that tell them they should become a heart cell. Dr Furtado said they could be the best cells to use in replacement therapies, because they are the only fibroblasts in the body that have these characteristics.

"The cardiac fibroblasts are truly unique, no other cells remember where they came from, but these remember that they are heart cells. They hold the key to tackling changes that result in heart failure. Through our research our ultimate aim is to modify these cells so that we can improve the function of a sick heart," Dr Furtado said.

Dr Furtado and her team at ARMI will continue their research into heart cells, with a particular focus on fibroblasts. Development in this area will potentially lead to obtaining the cells from patients and modifying them in a laboratory to explore patient tailored therapies, promoting better outcome for patients with heart disease.


'/>"/>

Contact: Kate Howard
monash.media@monash.edu
619-903-4840
Monash University
Source:Eurekalert

Related medicine news :

1. Screening detects ovarian cancer using neighboring cells
2. Following a proteins travel inside cells is key to improving patient monitoring, drug development
3. Dustman protein helps bin cancer cells
4. Efficient analysis of small quantity of cells improves chances to understand disease
5. New human trial shows stem cells are effective for failing hearts
6. Plasma tool for destroying cancer cells
7. Research reveals new depths of complexity in nerve cells
8. p53 cuts off invading cancer cells
9. Halting immune response could save brain cells after stroke
10. Stem cells inside sutures could improve healing in Achilles tendon injuries
11. UV light aids cancer cells that creep along the outside of blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... 2017 , ... Accreditation Commission for Health Care (ACHC) is ... (HCAOA). This agreement allows HCAOA members to receive special pricing on ACHC’s Home ... University (AU) educational resources that help prepare HCAOA members for ACHC Accreditation. , ...
(Date:4/28/2017)... ... ... Horizon Blue Cross Blue Shield of New Jersey (BCBSNJ) announced today that ... as “stable.” At the same time, the ratings agency cautioned that the company’s rating ... “capital adequacy” thresholds required for its strong rating. , “Horizon is committed to being ...
(Date:4/28/2017)... ... April 28, 2017 , ... ... tubes . These lamps offer an instant energy-saving solution for F32T8 fluorescent lamps ... fixtures or disconnect ballasts. These 50,000 hour rated lamps utilize the existing electronic ...
(Date:4/28/2017)... ... ... The Texas Cord Blood Bank (TCBB), a program of nonprofit biomedical organization GenCure, ... at Renaissance in Edinburg for their outstanding efforts in collecting umbilical cord blood donations ... , “Women’s Hospital at Renaissance has been a collection partner for the TCBB since ...
(Date:4/28/2017)... Ca (PRWEB) , ... April 28, 2017 , ... Bill ... management industry in the coastal communities. After Tina Howe joined the team, the Bill ... happy employees, honest services at affordable rates, and giving back to the San Diego ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017  IRIDEX Corporation (Nasdaq: ... financial results for the first quarter 2017 after the ... Company,s management team will host a corresponding conference call ... Investors interested in listening to the conference ... domestic callers or (703) 326-3030 for international callers, using ...
(Date:4/19/2017)... April 19, 2017 Global Prostate Cancer ... on the prostate cancer therapeutics market analyzes the ... Increasing prevalence of prostate cancer, launch of promising ... development of new drugs & therapeutic biological products, ... due to lesser side effects are some of ...
(Date:4/19/2017)... -- The Global Effective Microorganisms (EM) Market by ... covered and analysed the potential of Global Effective Microorganisms (EM) ... and growth factors. The report identifies and analyses the emerging ... global market. ... Tables and Figures, 6 Major Company Profiles, spread across 124 ...
Breaking Medicine Technology: