Navigation Links
Boring cells could hold the key to heart disease
Date:4/24/2014

Fibroblasts, cells long thought to be boring and irrelevant, could offer an alternative to heart transplants for patients with heart disease.

Researcher Dr Milena Furtado, and her team from the Australian Regenerative Medicine Institute (ARMI) at Monash University, found the heart cell fibroblast is a close relative to a cardiomyocyte, the cell responsible for a healthy beating heart.

In research published today in Circulation Research, Dr Furtado has found that cardiac fibroblasts are unique cells due to their genetic program, and will aid in the development of cell therapies for congenital heart disease and heart failure.

"Heart disease is still one of the major killers in our society and so far no effective therapeutic options are available. Our laboratory aims to understand how the various cell types present in a heart can improve the outcome of heart failure,' Dr Furtado said.

"Fibroblasts were thought to act as a sort of biological glue, making sure that all parts of the body work effectively. We now know they are far more specialised than that and have organ specific functions."

Using cutting edge technology, the team found that cardiac fibroblasts have specific genes called transcription factors that tell them they should become a heart cell. Dr Furtado said they could be the best cells to use in replacement therapies, because they are the only fibroblasts in the body that have these characteristics.

"The cardiac fibroblasts are truly unique, no other cells remember where they came from, but these remember that they are heart cells. They hold the key to tackling changes that result in heart failure. Through our research our ultimate aim is to modify these cells so that we can improve the function of a sick heart," Dr Furtado said.

Dr Furtado and her team at ARMI will continue their research into heart cells, with a particular focus on fibroblasts. Development in this area will potentially lead to obtaining the cells from patients and modifying them in a laboratory to explore patient tailored therapies, promoting better outcome for patients with heart disease.


'/>"/>

Contact: Kate Howard
monash.media@monash.edu
619-903-4840
Monash University
Source:Eurekalert

Related medicine news :

1. Screening detects ovarian cancer using neighboring cells
2. Following a proteins travel inside cells is key to improving patient monitoring, drug development
3. Dustman protein helps bin cancer cells
4. Efficient analysis of small quantity of cells improves chances to understand disease
5. New human trial shows stem cells are effective for failing hearts
6. Plasma tool for destroying cancer cells
7. Research reveals new depths of complexity in nerve cells
8. p53 cuts off invading cancer cells
9. Halting immune response could save brain cells after stroke
10. Stem cells inside sutures could improve healing in Achilles tendon injuries
11. UV light aids cancer cells that creep along the outside of blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... , ... June 27, 2016 , ... ... , the only authorized OSHA Training Institute Education Center headquartered in Northern California, ... their workers from extreme heat at their worksites. Employers with workers exposed ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... "FCPX editors ... customizable inside of Final Cut Pro X," said Christina Austin - CEO of Pixel ... style. Final Cut Pro X users can now reveal the media of ...
(Date:6/27/2016)... ... , ... TherapySites, the leading website and online ... Counseling Association. This new relationship allows TherapySites to continue to extend their ... benefits and promotional offers. , "TCA is extremely excited about this new partnership, ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... payment industry today announced its strategic partnership with Connance, a healthcare industry ... The two companies’ proven, proprietary technology combine to provide health systems, hospitals ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... transport experience for the millions of people who require these medical transport services ... industry through the use of technology. Now, SmartEMS has put forth an industry-changing ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 Roche ... received 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) ... severe sepsis or septic shock. With this clearance, Roche ... provide a fully integrated solution for sepsis risk assessment ... associated with bacterial infection and PCT levels in blood ...
(Date:6/23/2016)... 2016 Capricor Therapeutics, Inc. ... biotechnology company focused on the discovery, development and ... enrollment in its ongoing randomized HOPE-Duchenne clinical trial ... of its 24-patient target. Capricor expects the trial ... of 2016, and to report top line data ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology and specialty ... Bracket eCOA (SM) 6.0, at the 52 nd ... in Philadelphia , Pennsylvania.  A demonstration of ... its kind to fully integrate with RTSM, will be held ... a flexible platform for electronic clinical outcomes assessments that is ...
Breaking Medicine Technology: