Navigation Links
Boring cells could hold the key to heart disease
Date:4/24/2014

Fibroblasts, cells long thought to be boring and irrelevant, could offer an alternative to heart transplants for patients with heart disease.

Researcher Dr Milena Furtado, and her team from the Australian Regenerative Medicine Institute (ARMI) at Monash University, found the heart cell fibroblast is a close relative to a cardiomyocyte, the cell responsible for a healthy beating heart.

In research published today in Circulation Research, Dr Furtado has found that cardiac fibroblasts are unique cells due to their genetic program, and will aid in the development of cell therapies for congenital heart disease and heart failure.

"Heart disease is still one of the major killers in our society and so far no effective therapeutic options are available. Our laboratory aims to understand how the various cell types present in a heart can improve the outcome of heart failure,' Dr Furtado said.

"Fibroblasts were thought to act as a sort of biological glue, making sure that all parts of the body work effectively. We now know they are far more specialised than that and have organ specific functions."

Using cutting edge technology, the team found that cardiac fibroblasts have specific genes called transcription factors that tell them they should become a heart cell. Dr Furtado said they could be the best cells to use in replacement therapies, because they are the only fibroblasts in the body that have these characteristics.

"The cardiac fibroblasts are truly unique, no other cells remember where they came from, but these remember that they are heart cells. They hold the key to tackling changes that result in heart failure. Through our research our ultimate aim is to modify these cells so that we can improve the function of a sick heart," Dr Furtado said.

Dr Furtado and her team at ARMI will continue their research into heart cells, with a particular focus on fibroblasts. Development in this area will potentially lead to obtaining the cells from patients and modifying them in a laboratory to explore patient tailored therapies, promoting better outcome for patients with heart disease.


'/>"/>

Contact: Kate Howard
monash.media@monash.edu
619-903-4840
Monash University
Source:Eurekalert

Related medicine news :

1. Screening detects ovarian cancer using neighboring cells
2. Following a proteins travel inside cells is key to improving patient monitoring, drug development
3. Dustman protein helps bin cancer cells
4. Efficient analysis of small quantity of cells improves chances to understand disease
5. New human trial shows stem cells are effective for failing hearts
6. Plasma tool for destroying cancer cells
7. Research reveals new depths of complexity in nerve cells
8. p53 cuts off invading cancer cells
9. Halting immune response could save brain cells after stroke
10. Stem cells inside sutures could improve healing in Achilles tendon injuries
11. UV light aids cancer cells that creep along the outside of blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... 31, 2016 , ... The successful implementation of “lean manufacturing” in various fields ... laboratories have different challenges compared to manufacturing environments. , In order to provide ... TOLEDO has developed the Lean Lab Checklist . This checklist will help users ...
(Date:5/31/2016)... ... May 31, 2016 , ... In ... can describe personality traits in humans. Using presidential candidate Donald Trump as an ... vitality. , “AstroNumerology is not about adding numbers up,” says Kalsi. “It ...
(Date:5/31/2016)... ... ... Phynd Technologies, Inc. announced recently the signing of three new hospitals: Meadows ... Center – Somers Point, NJ. The new clients range in bed size from 57 ... Phynd’s solution and its interoperability. , Houston Methodist is a leading academic medical center ...
(Date:5/31/2016)... (PRWEB) , ... May 31, 2016 , ... Dr. Charles ... and Dentistry of New Jersey in the class of 1986, where he graduated in ... dentistry at his current location in Livingston since 1989. He has been a member ...
(Date:5/31/2016)... Washington, NY (PRWEB) , ... May 31, 2016 , ... ... other essential nutrients to on the go individuals and dedicated athletes, continues to transform ... , Loaded with whey, pea and milk protein, branched-chain amino acids (BCAA), alkaline ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... RnRMarketResearch.com adds "Asthma - Pipeline ... of Asthma therapy at various stages, therapeutics assessment by ... (RoA) and molecule type, along with latest updates, and ... players involved in the therapeutic development for Asthma and ... Complete report on H1 2016 pipeline review of Asthma ...
(Date:5/30/2016)... 2016 According to ... Market by Technology (Single-factor (Fingerprint, Face, Iris, ... (Workforce Management), End User (Hospitals, Healthcare Institutions) ... MarketsandMarkets, the market is projected to reach ... 1,182.6 Million by 2016, at a CAGR ...
(Date:5/30/2016)... May 30, 2016 The ... USD 7.3 billion by 2024, according to a ... increasing natality rate, the growing malnutrition coupled with ... and gastro-intestinal tract diseases are expected to boost ...      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) , ...
Breaking Medicine Technology: