Navigation Links
Boring cells could hold the key to heart disease
Date:4/24/2014

Fibroblasts, cells long thought to be boring and irrelevant, could offer an alternative to heart transplants for patients with heart disease.

Researcher Dr Milena Furtado, and her team from the Australian Regenerative Medicine Institute (ARMI) at Monash University, found the heart cell fibroblast is a close relative to a cardiomyocyte, the cell responsible for a healthy beating heart.

In research published today in Circulation Research, Dr Furtado has found that cardiac fibroblasts are unique cells due to their genetic program, and will aid in the development of cell therapies for congenital heart disease and heart failure.

"Heart disease is still one of the major killers in our society and so far no effective therapeutic options are available. Our laboratory aims to understand how the various cell types present in a heart can improve the outcome of heart failure,' Dr Furtado said.

"Fibroblasts were thought to act as a sort of biological glue, making sure that all parts of the body work effectively. We now know they are far more specialised than that and have organ specific functions."

Using cutting edge technology, the team found that cardiac fibroblasts have specific genes called transcription factors that tell them they should become a heart cell. Dr Furtado said they could be the best cells to use in replacement therapies, because they are the only fibroblasts in the body that have these characteristics.

"The cardiac fibroblasts are truly unique, no other cells remember where they came from, but these remember that they are heart cells. They hold the key to tackling changes that result in heart failure. Through our research our ultimate aim is to modify these cells so that we can improve the function of a sick heart," Dr Furtado said.

Dr Furtado and her team at ARMI will continue their research into heart cells, with a particular focus on fibroblasts. Development in this area will potentially lead to obtaining the cells from patients and modifying them in a laboratory to explore patient tailored therapies, promoting better outcome for patients with heart disease.


'/>"/>

Contact: Kate Howard
monash.media@monash.edu
619-903-4840
Monash University
Source:Eurekalert

Related medicine news :

1. Screening detects ovarian cancer using neighboring cells
2. Following a proteins travel inside cells is key to improving patient monitoring, drug development
3. Dustman protein helps bin cancer cells
4. Efficient analysis of small quantity of cells improves chances to understand disease
5. New human trial shows stem cells are effective for failing hearts
6. Plasma tool for destroying cancer cells
7. Research reveals new depths of complexity in nerve cells
8. p53 cuts off invading cancer cells
9. Halting immune response could save brain cells after stroke
10. Stem cells inside sutures could improve healing in Achilles tendon injuries
11. UV light aids cancer cells that creep along the outside of blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to ... unique items from across the nation, this holiday-themed event will raise funds and awareness ... VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented ... the lowdown on sciatica in a new episode of "Success Files," which is ... events and innovation and investigates each subject in-depth with passion and integrity. , ...
(Date:10/12/2017)... ... October 12, 2017 , ... First ... compliance program management, will showcase a range of technology and learning solutions at ... (NCAL) Convention and Expo to be held October 14–18, 2017 at the Mandalay ...
(Date:10/12/2017)... ... 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of ... innovative new design of the shoulder pad. The shoulder pad provides optimal support ... your pain while using cold therapy. By utilizing ice and water that is circulated ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, ... a medical article to the newly revamped Cosmetic Town journal section, ... hair transplant procedure known as Follicular Unit Extraction (FUE). , Dr. ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)...  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided ... Piedras, Puerto Rico , where the ... Following a comprehensive onsite ... structural damage, temporary loss of power and minimal water ... manufacturing operations have resumed, and the company expects to ...
(Date:10/4/2017)...  South Korean-based healthcare product Development Company I.M. Lab ... Kickstarter. The device will educate the user about ,proper, ... efficiency compared to the dated and pricey CPR training ... of the compression for a more informed CPR training. ... raise $5,000. cprCUBE ...
(Date:10/2/2017)... 2, 2017  AllianceRx Walgreens Prime, the combined central ... and pharmacy benefit manager Prime Therapeutics LLC (Prime), today ... included the unveiling of new signage at its headquarters ... as at a few other company-owned facilities across the ... patients, some of whom will begin to see the ...
Breaking Medicine Technology: