Navigation Links
Border patrol: Immune cells protect body from invaders, according to Penn study
Date:2/7/2011

PHILADELPHIA - So-called barrier sites -- the skin, gut, lung limit the inner body's exposure to allergens, pollutants, viruses, bacteria, and parasites. Understanding how the immune system works in these external surfaces has implications for understanding such inflammatory diseases as asthma, psoriasis, IBD, and food allergies, all of which occur at the body's barriers.

David Artis, PhD, professor of Microbiology and Gregory F. Sonnenberg, a predoctoral fellow in the Artis lab, have identified an immune cell population that acts as the body's border patrol with the outside world. They discovered that these lymphoid tissue inducer cells maintain immunity in the intestine of mice. The research appeared in the most recent online issue of Immunity.

Following infection by Citrobacter rodentium -- a model of human E. coli infection in the gut this cell population was the dominant source of IL-22, a molecule that helps in the immune response during the early phases of infection. When the inducer cells were eliminated from the intestine of the experimental mice, immunity was impaired, affecting the production of anti-microbial proteins required to fight infection. The mice eventually died.

This discovery could also represent a new line of research for HIV/AIDS, says Artis, since there is a breakdown of barrier immunity in the gut (a reservoir for HIV) that can lead to full blown AIDS. Therapeutics to target such immune cells could be an important new way to combat AIDS.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1

Related medicine news :

1. Border collie comprehends over 1,000 object names
2. Kameda Medical Center to Release Patients Beyond Borders “Focus On™”
3. New initiative aims at safer food imports -- at the source, not our border
4. Crossborder Services, LLC Offers Insurance Options for Visitors and New Immigrants to USA
5. Prince Court Medical Center in Malaysia to Release First Patients Beyond Borders FOCUS ON:™
6. Breast cancer cells outsmart the immune system and thrive
7. Novel immune system-based gene therapy induces strong responses in metastatic melanoma, sarcoma
8. Pre-surgical stress management boosts immune function, lowers mood disturbance in prostate cancer patients
9. Stimulating the brains immune response may provide treatment for Alzheimers disease
10. Viral protein mimic keeps immune system quiet
11. Patent awarded for method to dampen immune response
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Border patrol: Immune cells protect body from invaders, according to Penn study
(Date:12/25/2014)... 25, 2014 When head lice hits a ... a frenzy to get rid of it while keeping it ... Coral Gables now have the solution right in their neighborhood: ... location, Lice Troopers provides full spectrum head lice screening and ... area, including Sunset, Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest ...
(Date:12/25/2014)... THURSDAY, Dec. 25, 2014 (HealthDay News) -- The risk ... the holidays, so you need to be extra cautious, ... Day, we see a significant increase in patients coming ... at the Suffolk County Volunteer Firefighters Burn Center of ... celebrations should be full of joy, but if not ...
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. ... on a "fountain of youth" drug that can delay the ... a new study suggests. Seniors received a significant boost ... a genetic signaling pathway linked to aging and immune function, ... The experimental medication, a version of the drug rapamycin, improved ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 “ SmileStix ” ... which features the latest and coolest mobile applications on the ... expert and host of NewsWatch, conducted the app review and ... to create personal stickers. , The old saying goes, “A ... lot of words that can describe a single image, because ...
(Date:12/25/2014)... CA (PRWEB) December 25, 2014 Each ... visits and 2 million hospital admissions across the nation ... Prevention ). The CDC’s National Hospital Ambulatory Medical ... through a survey conducted in 2010. They estimated that ... visits that resulted in a primary diagnosis of broken ...
Breaking Medicine News(10 mins):Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Don't Let Burns Mar Your Holidays 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4
... Modern cancer care is critically dependent on imaging ... and guide their therapy or surgery. Molecular imaging ... characteristics of malignancies, tumor stage and therapeutical response, ... assess the tumor,s anatomical or morphologic features including ...
... markers were analyzed in 83 cases of colorectal ... chain reaction (PCR). PCR products were eletrophoresed on ... Genotype 3.7 software were used for loss of ... features, significant relationship was observed between LOH frequencies ...
... CHICAGO, Sept. 24 "The Lions are coming!,Look for them ... and Saturday, October 10 and 11 for Lions Candy Day, ... The face of Lionism was changed forever in Illinois in ... to "man" the street corners giving,away small plastic white cane ...
... to massage for relief, EVANSTON, Ill., Sept. 24 ... massage therapy for relaxation, according to the 12th,annual consumer ... survey found that 59 percent of Americans are,more stressed ... are the,top reasons Americans received their last massage. These ...
... Available on, http://www.flucliniclocator.org, Helps People Find Local ... The American Lung,Association is making it a ... shot,this season with the availability of its 2008-2009 ... influenza vaccination clinics is now,available at http://www.flucliniclocator.org ...
... UCSF scientists are among the 31 nationwide who ... National Institutes of Health. The awards are designed ... that could transform biomedical and behavioral science." , ... costs over five years, were awarded to Yuriy ...
Cached Medicine News:Health News:LOH analysis on 4q in sporadic colorectal carcinoma 2Health News:Lions Taking to the Street Corners! 2Health News:Massage Therapy Use Holds Steady, Despite Lagging Economy 2Health News:Massage Therapy Use Holds Steady, Despite Lagging Economy 3Health News:American Lung Association Joins Health Officials to Prevent the Spread of Influenza by Urging People to Get Vaccinated 2Health News:American Lung Association Joins Health Officials to Prevent the Spread of Influenza by Urging People to Get Vaccinated 3Health News:American Lung Association Joins Health Officials to Prevent the Spread of Influenza by Urging People to Get Vaccinated 4Health News:2 UCSF scientists recognized for transformative research 2Health News:2 UCSF scientists recognized for transformative research 3
(Date:12/24/2014)... Dec. 24, 2014  Diplomat Pharmacy, Inc. (NYSE: ... is proud to announce Jennifer Hagerman , Pharm.D., ... will take office as the president of the Michigan ... ceremony will take place Feb. 28, 2015, at the ... at the Renaissance Center in Detroit, Michigan ...
(Date:12/24/2014)... Dec. 23, 2014 PuraMed BioScience®, Inc., (OTC ... (OTC) medicinal and healthcare products, announced it received the ... a hemp-based, advanced headache relief product, for planned distribution ... Colorado , Washington State ... With the MigraPure H Advanced headache relief gel formulation ...
(Date:12/24/2014)... DIEGO , Dec. 23, 2014 ResMed (NYSE: ... significant patent infringement action against Chinese medical device manufacturer BMC ... (ITC) ruled today that BMC,s masks listed below infringe ResMed,s ... or selling these masks in the United States ... iVolve N2 nasal mask , Willow nasal pillows mask ...
Breaking Medicine Technology:Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: