Navigation Links
Border patrol: Immune cells protect body from invaders, according to Penn study

PHILADELPHIA - So-called barrier sites -- the skin, gut, lung limit the inner body's exposure to allergens, pollutants, viruses, bacteria, and parasites. Understanding how the immune system works in these external surfaces has implications for understanding such inflammatory diseases as asthma, psoriasis, IBD, and food allergies, all of which occur at the body's barriers.

David Artis, PhD, professor of Microbiology and Gregory F. Sonnenberg, a predoctoral fellow in the Artis lab, have identified an immune cell population that acts as the body's border patrol with the outside world. They discovered that these lymphoid tissue inducer cells maintain immunity in the intestine of mice. The research appeared in the most recent online issue of Immunity.

Following infection by Citrobacter rodentium -- a model of human E. coli infection in the gut this cell population was the dominant source of IL-22, a molecule that helps in the immune response during the early phases of infection. When the inducer cells were eliminated from the intestine of the experimental mice, immunity was impaired, affecting the production of anti-microbial proteins required to fight infection. The mice eventually died.

This discovery could also represent a new line of research for HIV/AIDS, says Artis, since there is a breakdown of barrier immunity in the gut (a reservoir for HIV) that can lead to full blown AIDS. Therapeutics to target such immune cells could be an important new way to combat AIDS.


Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Page: 1

Related medicine news :

1. Border collie comprehends over 1,000 object names
2. Kameda Medical Center to Release Patients Beyond Borders “Focus On™”
3. New initiative aims at safer food imports -- at the source, not our border
4. Crossborder Services, LLC Offers Insurance Options for Visitors and New Immigrants to USA
5. Prince Court Medical Center in Malaysia to Release First Patients Beyond Borders FOCUS ON:™
6. Breast cancer cells outsmart the immune system and thrive
7. Novel immune system-based gene therapy induces strong responses in metastatic melanoma, sarcoma
8. Pre-surgical stress management boosts immune function, lowers mood disturbance in prostate cancer patients
9. Stimulating the brains immune response may provide treatment for Alzheimers disease
10. Viral protein mimic keeps immune system quiet
11. Patent awarded for method to dampen immune response
Post Your Comments:
Related Image:
Border patrol: Immune cells protect body from invaders, according to Penn study
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... On Friday, ... presented a Bronze Wellness at Work award to iHire in recognition of their exemplary ... part of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin ... companies that call for a minimum wage raise to $12 an hour by 2020 and ... This will restore the lost value of the minimum wage, assure the wage floor does ...
(Date:6/24/2016)... ... 2016 , ... Strategic Capital Partners, LLC (SCP) in concert ... capital for emerging technology companies. SCP has delivered investment events and professional ... than a million dollars of capital investment for five companies. The ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)... 24, 2016 The Academy of Managed Care ... that would allow biopharmaceutical companies to more easily ... make formulary and coverage decisions, a move that addresses ... medicines. The recommendations address restrictions in the ... the drug label, a prohibition that hinders decision makers ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
Breaking Medicine Technology: