Navigation Links
Boosting Brain Protein Quickly Cut Excessive Drinking
Date:6/13/2008

New approach stopped desire to imbibe in as little as 10 minutes, animal study finds

FRIDAY, June 13 (HealthDay News) -- Boosting the level of a specific brain protein may rapidly halt excessive alcohol consumption, according to a new study done in animals.

University of California, San Francisco, researchers found that the excessive amounts of GDNF, or glial cell-derived neurotrophic factor, stopped the desire to drink alcohol in as little as 10 minutes when tested on rats. Other rodents that had been "rehabbed" to give up alcohol also did not suffer a relapse into heavy imbibing when reintroduced to alcohol and given a GDNF boost.

GDNF shows additional promise, because it does not appear to have any side effects or block other more normal "pleasure-seeking behaviors," such as craving sweets, the researchers report.

"Alcoholism is a devastating and costly psychiatric disease with enormous socioeconomic impact," senior study author Dorit Ron, the principal investigator at the UCSF-affiliated Ernest Gallo Clinic and Research Center, said in a prepared statement. "There is a tremendous need for therapies to treat alcohol abuse."

"Unfortunately, only three drugs are currently approved to treat excessive drinking, and all have serious limitations. Our findings open the door to a promising new strategy to combat alcohol abuse, addiction and especially relapse," he said.

Gallo researchers reported in 2005 that increased levels of GDNF appeared to cut the craving for alcohol, but they did not know how fast or effective it might be. GDNF is also being studied as a treatment for Parkinson's disease.

The researchers are searching to find whether any FDA-approved drugs might stimulate GDNF activity in the brain. Only one orally delivered drug, developed for experiments in the pursuit of Parkinson's treatments, has been shown to raise brain GDNF levels in rats.

The findings were published in this week's Proceedings of the National Academy of Sciences.

More information

The U.S. National Institute on Alcohol Abuse and Alcoholism has more about alcohol abuse and alcoholism.



-- Kevin McKeever



SOURCE: University of California, San Francisco, news release, June 9, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. U.S. Schools Getting Better at Boosting Kids Health
2. Mayo Clinic researchers: Insulin-boosting medication does not impair ability to survive heart attack
3. Boosting Pharma Sales Force Effectiveness through Streamlined Internal Communications
4. Drug Therapy Boosting Heart-Attack Survival Rates
5. Immune-Boosting Lung Cancer Therapy Shows Promise
6. Draining away brains toxic protein to stop Alzheimers
7. Vision restoration therapy shown to improve brain activity in brain injured patients
8. Clinical depression linked to abnormal emotional brain circuits
9. Brain imaging reveals breakdown of normal emotional processing
10. Brain cells work differently than previously thought
11. Vaccine Stops Alzheimers Brain Tangles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2017)... ... September 19, 2017 , ... ... cry to Americans to watch for the discomforts and hidden dangers of foot ... senior citizens, everyone is at risk for developing fungal infections on the feet ...
(Date:9/19/2017)... (PRWEB) , ... September 19, 2017 , ... The Semper ... their families, announces the release of a series of videos and a compelling documentary ... service members in the United States as part of its ongoing mission. , Each ...
(Date:9/19/2017)... NJ (PRWEB) , ... September 19, 2017 , ... ... following the success of the annual PAINWeek National Conference. On October 7, at ... be an educational and exciting program providing busy clinicians and allied healthcare practitioners ...
(Date:9/19/2017)... Calif (PRWEB) , ... September ... ... DVM, MS, DACVIM, a board-certified veterinary oncologist, has agreed to serve as ... warrants SNOAW). Dr. Tripp is founder of the Bridge Animal Referral ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... with the Davidson Fellows Scholarship on September 27 at a reception in Washington ... Technology, Engineering, Mathematics, Literature and Music. , “I am honored to be a ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... ALLENTOWN , Pa. and KALAMAZOO, Mich. ... Allentown, Penn. , and OptiMed Specialty Pharmacy ... a business partnership to offer a strategic hub service ... PMD Healthcare,s highly sought-after personal spirometer, Spiro PD 2.0, ... A spirometer is a medical device used ...
(Date:9/12/2017)... 12, 2017   EcoVadis , the leading platform for environmental, social ... annual edition of its Global CSR Risk and Performance Index. The report ... based on Scorecard Ratings that analyzed nearly 800,000 data points across the ... ... ...
(Date:9/9/2017)... ... ... Monday, September 18 th .The Brain Tumor Foundation (BTF) begins a week-long ... BTF,s Mobile MRI Unit – a 70 Ft. ... brings its nationwide initiative, the Road to Early Detection Sponsor-A-City Campaign to ...
Breaking Medicine Technology: