Navigation Links
Boosting Brain Protein Quickly Cut Excessive Drinking
Date:6/13/2008

New approach stopped desire to imbibe in as little as 10 minutes, animal study finds

FRIDAY, June 13 (HealthDay News) -- Boosting the level of a specific brain protein may rapidly halt excessive alcohol consumption, according to a new study done in animals.

University of California, San Francisco, researchers found that the excessive amounts of GDNF, or glial cell-derived neurotrophic factor, stopped the desire to drink alcohol in as little as 10 minutes when tested on rats. Other rodents that had been "rehabbed" to give up alcohol also did not suffer a relapse into heavy imbibing when reintroduced to alcohol and given a GDNF boost.

GDNF shows additional promise, because it does not appear to have any side effects or block other more normal "pleasure-seeking behaviors," such as craving sweets, the researchers report.

"Alcoholism is a devastating and costly psychiatric disease with enormous socioeconomic impact," senior study author Dorit Ron, the principal investigator at the UCSF-affiliated Ernest Gallo Clinic and Research Center, said in a prepared statement. "There is a tremendous need for therapies to treat alcohol abuse."

"Unfortunately, only three drugs are currently approved to treat excessive drinking, and all have serious limitations. Our findings open the door to a promising new strategy to combat alcohol abuse, addiction and especially relapse," he said.

Gallo researchers reported in 2005 that increased levels of GDNF appeared to cut the craving for alcohol, but they did not know how fast or effective it might be. GDNF is also being studied as a treatment for Parkinson's disease.

The researchers are searching to find whether any FDA-approved drugs might stimulate GDNF activity in the brain. Only one orally delivered drug, developed for experiments in the pursuit of Parkinson's treatments, has been shown to raise brain GDNF levels in rats.

The findings were published in this week's Proceedings of the National Academy of Sciences.

More information

The U.S. National Institute on Alcohol Abuse and Alcoholism has more about alcohol abuse and alcoholism.



-- Kevin McKeever



SOURCE: University of California, San Francisco, news release, June 9, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. U.S. Schools Getting Better at Boosting Kids Health
2. Mayo Clinic researchers: Insulin-boosting medication does not impair ability to survive heart attack
3. Boosting Pharma Sales Force Effectiveness through Streamlined Internal Communications
4. Drug Therapy Boosting Heart-Attack Survival Rates
5. Immune-Boosting Lung Cancer Therapy Shows Promise
6. Draining away brains toxic protein to stop Alzheimers
7. Vision restoration therapy shown to improve brain activity in brain injured patients
8. Clinical depression linked to abnormal emotional brain circuits
9. Brain imaging reveals breakdown of normal emotional processing
10. Brain cells work differently than previously thought
11. Vaccine Stops Alzheimers Brain Tangles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... ... July 21, 2017 , ... The ... offer patients improved quality of life five years after injury, according to research ... Meeting in Toronto, Ontario, Canada. The study followed patients for five years following ...
(Date:7/20/2017)... ... July 20, 2017 , ... ChenMed , a leading provider ... JenCare Senior Medical Center as Richmond Chief Medical Officer. Dr. McCarter, formerly ... Associate Chief Medical Officer of Ambulatory Services for the UVA Health System, brings 30 ...
(Date:7/20/2017)... (PRWEB) , ... July 20, 2017 , ... ... law firm headquartered in Houston, is pleased to announce their expansion to the ... affordable housing experience, directors Alysse Hollis and Ronald Bell, and of counsels, John ...
(Date:7/20/2017)... ... ... Team Type 1 Foundation, a nonprofit organization pursuing a global mission of education, ... with a Microsoft Corp. employee-led hackathon team for the 2017 Microsoft One Week Hackathon ... 1’s mission overlaps seamlessly with Microsoft’s mission to empower every person and every organization ...
(Date:7/20/2017)... ... 2017 , ... Girl Up Campaign Director, Melissa Kilby, released ... support of providing girls access to education in refugee settings. In May, Congressman Steve ... Access to Education in Vulnerable Settings Act.” Yesterday, companion legislation was introduced in ...
Breaking Medicine News(10 mins):
(Date:7/15/2017)... 2017 Enterin Inc., a Philadelphia ... (PD), today announced the completion of a $12.7 million Series ... III, as well as the participation of existing investors. ... have the support of New Ventures III and our current ... of the potential of our platform technology to transform the ...
(Date:7/13/2017)... Calif. , July 13, 2017 RK Logistics ... Board of Pharmacy certification for its Fremont, CA ... support solutions in the Tri-Valley and San Jose ... City of Fremont , with its Fremont ... Group to provide such a powerful resource to the hundreds ...
(Date:7/11/2017)... July 11, 2017 Zymo Research Corp., also known as ,The ... quantify biological aging in a precise manner using the myDNAge ™ ... , a professor of human genetics and biostatistics at the David ... Public Health , Zymo Research,s proprietary DNAge ™ technology is used ... ...
Breaking Medicine Technology: