Navigation Links
Boosting Brain Protein Quickly Cut Excessive Drinking
Date:6/13/2008

New approach stopped desire to imbibe in as little as 10 minutes, animal study finds

FRIDAY, June 13 (HealthDay News) -- Boosting the level of a specific brain protein may rapidly halt excessive alcohol consumption, according to a new study done in animals.

University of California, San Francisco, researchers found that the excessive amounts of GDNF, or glial cell-derived neurotrophic factor, stopped the desire to drink alcohol in as little as 10 minutes when tested on rats. Other rodents that had been "rehabbed" to give up alcohol also did not suffer a relapse into heavy imbibing when reintroduced to alcohol and given a GDNF boost.

GDNF shows additional promise, because it does not appear to have any side effects or block other more normal "pleasure-seeking behaviors," such as craving sweets, the researchers report.

"Alcoholism is a devastating and costly psychiatric disease with enormous socioeconomic impact," senior study author Dorit Ron, the principal investigator at the UCSF-affiliated Ernest Gallo Clinic and Research Center, said in a prepared statement. "There is a tremendous need for therapies to treat alcohol abuse."

"Unfortunately, only three drugs are currently approved to treat excessive drinking, and all have serious limitations. Our findings open the door to a promising new strategy to combat alcohol abuse, addiction and especially relapse," he said.

Gallo researchers reported in 2005 that increased levels of GDNF appeared to cut the craving for alcohol, but they did not know how fast or effective it might be. GDNF is also being studied as a treatment for Parkinson's disease.

The researchers are searching to find whether any FDA-approved drugs might stimulate GDNF activity in the brain. Only one orally delivered drug, developed for experiments in the pursuit of Parkinson's treatments, has been shown to raise brain GDNF levels in rats.

The findings were published in this week's Proceedings of the National Academy of Sciences.

More information

The U.S. National Institute on Alcohol Abuse and Alcoholism has more about alcohol abuse and alcoholism.



-- Kevin McKeever



SOURCE: University of California, San Francisco, news release, June 9, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. U.S. Schools Getting Better at Boosting Kids Health
2. Mayo Clinic researchers: Insulin-boosting medication does not impair ability to survive heart attack
3. Boosting Pharma Sales Force Effectiveness through Streamlined Internal Communications
4. Drug Therapy Boosting Heart-Attack Survival Rates
5. Immune-Boosting Lung Cancer Therapy Shows Promise
6. Draining away brains toxic protein to stop Alzheimers
7. Vision restoration therapy shown to improve brain activity in brain injured patients
8. Clinical depression linked to abnormal emotional brain circuits
9. Brain imaging reveals breakdown of normal emotional processing
10. Brain cells work differently than previously thought
11. Vaccine Stops Alzheimers Brain Tangles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: