Navigation Links
Boosting Brain Protein Quickly Cut Excessive Drinking

New approach stopped desire to imbibe in as little as 10 minutes, animal study finds

FRIDAY, June 13 (HealthDay News) -- Boosting the level of a specific brain protein may rapidly halt excessive alcohol consumption, according to a new study done in animals.

University of California, San Francisco, researchers found that the excessive amounts of GDNF, or glial cell-derived neurotrophic factor, stopped the desire to drink alcohol in as little as 10 minutes when tested on rats. Other rodents that had been "rehabbed" to give up alcohol also did not suffer a relapse into heavy imbibing when reintroduced to alcohol and given a GDNF boost.

GDNF shows additional promise, because it does not appear to have any side effects or block other more normal "pleasure-seeking behaviors," such as craving sweets, the researchers report.

"Alcoholism is a devastating and costly psychiatric disease with enormous socioeconomic impact," senior study author Dorit Ron, the principal investigator at the UCSF-affiliated Ernest Gallo Clinic and Research Center, said in a prepared statement. "There is a tremendous need for therapies to treat alcohol abuse."

"Unfortunately, only three drugs are currently approved to treat excessive drinking, and all have serious limitations. Our findings open the door to a promising new strategy to combat alcohol abuse, addiction and especially relapse," he said.

Gallo researchers reported in 2005 that increased levels of GDNF appeared to cut the craving for alcohol, but they did not know how fast or effective it might be. GDNF is also being studied as a treatment for Parkinson's disease.

The researchers are searching to find whether any FDA-approved drugs might stimulate GDNF activity in the brain. Only one orally delivered drug, developed for experiments in the pursuit of Parkinson's treatments, has been shown to raise brain GDNF levels in rats.

The findings were published in this week's Proceedings of the National Academy of Sciences.

More information

The U.S. National Institute on Alcohol Abuse and Alcoholism has more about alcohol abuse and alcoholism.

-- Kevin McKeever

SOURCE: University of California, San Francisco, news release, June 9, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. U.S. Schools Getting Better at Boosting Kids Health
2. Mayo Clinic researchers: Insulin-boosting medication does not impair ability to survive heart attack
3. Boosting Pharma Sales Force Effectiveness through Streamlined Internal Communications
4. Drug Therapy Boosting Heart-Attack Survival Rates
5. Immune-Boosting Lung Cancer Therapy Shows Promise
6. Draining away brains toxic protein to stop Alzheimers
7. Vision restoration therapy shown to improve brain activity in brain injured patients
8. Clinical depression linked to abnormal emotional brain circuits
9. Brain imaging reveals breakdown of normal emotional processing
10. Brain cells work differently than previously thought
11. Vaccine Stops Alzheimers Brain Tangles
Post Your Comments:
(Date:11/30/2015)... Caicos Islands, BWI (PRWEB) , ... December 01, 2015 , ... ... Recently Caribbean Journal, one of the leading digital news sites highlighting Caribbean destinations, ... reason? The weather. While much of North America shivers under chilly grey skies ...
(Date:11/30/2015)... ... 01, 2015 , ... Live Very Well is excited to ... on . The multi-carrier insurance exchange platform offers individual vision and ... to compare, quote and match plans to meet their needs. , Beginning ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... four states in the U.S. require dental technicians to be certified or obtain ... industry, NADL created the “What’s In Your Mouth?” campaign to inform dentists that ...
(Date:11/30/2015)... ... November 30, 2015 , ... The world of hair transplants and restoration ... extraction. These techniques and procedures have been in use for many years and are ... Dr. Parsa Mohebi, M.D. has utilized many of these methods over the years, he ...
(Date:11/30/2015)... ... 30, 2015 , ... During the week of Thanksgiving, the ... for its research, education, support, and advocacy efforts. The campaign is held every ... Mesothelioma Applied Research Foundation, which also goes by Meso Foundation, holds the ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Nov. 30, 2015 MEDTEC Japan 2016, Asia,s ... is to be held in Tokyo from 20 th  - 22 nd April ... --> -->   --> --> ... the United States . With the aging population and the government ... grow steadily. --> the United States . With the ...
(Date:11/30/2015)... 30, 2015 Diplomat Pharmacy, Inc. (NYSE: ... the Detroit Free Press as a Top Workplace , ... to work for in 2015. ... 100 winners annually, based on employee surveys rating company leadership, ... Workplaces are based solely on employee feedback. The survey is ...
(Date:11/30/2015)...  IBA Molecular North America, Inc. (IBAMNA), a U.S. ... that as of January 1, 2016, it will do ... to rebrand the company reflects a refined vision for ... close relationship with Zevacor Molecular.  Both IBAMNA and Zevacor ... Peter Burke , Vice President Sales ...
Breaking Medicine Technology: