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Book by UCR biologist tells story of 100-year quest for elusive malaria vaccine
Date:9/29/2009

ts with birds and monkeys and a significant investment by the United States Agency for International Development (USAID), the National Institutes of Health, the US Army and Navy, and a host of other funding agencies, a protective malaria vaccine was not on the horizon.

Promises, Promises, Promises discusses how after the development of a method to grow Plasmodium falciparumthe most deadly of the human malaria parasitesin the laboratory, a cadre of well-trained scientists directed their studies toward the biochemistry and immunology of these parasites in the hope of discovering a protective vaccine; and the troubles associated with the USAID malaria vaccine initiative.

Hunting for Protective Blood Stage Antigens discusses how molecular techniques (monoclonal antibody and recombinant DNA) contributed to the identification of putative vaccine candidates.

Blocking Transmission discusses the non-vaccine and vaccine interventions designed to prevent or reduce the mosquito transmission of malaria.

Battling Blood Stages explains the connection between the immunity-inducing molecules (antigens) of the parasite stages living in the red blood cells and the development of vaccine candidates.

Of Mice and Men chronicles the trials of malaria vaccines using mouse malarias and identification of the sporozoite and liver stage antigens; and the protection afforded by irradiated sporozoites and RTS,S (a vaccine).

Informed by the Immune System describes the efforts of researchers using the immune response to identify the parasite molecules that elicit immunity and develop an immunity-provoking vaccine.

Why the Vaccine Remains Elusive stresses that malaria vaccines, when they arrive, will assist in transforming nations in the developing world from a state of poverty to one rich in health.

"Advocacy for malaria vaccines needs more than philanthropic and r
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Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside
Source:Eurekalert  

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