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Book by UCR biologist tells story of 100-year quest for elusive malaria vaccine
Date:9/29/2009

standing of the problem can result.

"There is no recent easily accessible chronicle of the preparation of malaria vaccines nor are there descriptions of the crusaders past and present who have labored to produce a protective vaccine against malaria. Further, the scientific literature does not convey a sense of the drama in the pursuit."

In the book's 13 chapters, Sherman captures the controversies, missteps, wars of words, stolen ideas, and clashes of ego as researchers around the world compete to develop the first successful malaria vaccine.

"It was my long association with malaria immunity and the search for vaccine candidates that prompted me to write about my own investigations and that of others in this century-long quest for a vaccine and to chronicle the advances, failures and the hopes for a safe and practical vaccine," he said.

The 402-page book covers a variety of topics, including immunity, immunology, recombinant DNA, antibodies, the importance of microbe hunters, and the need for responsible leadership in the battle against malaria.

The book's 13 chapters are:

Hunting Microbes discusses how researchers identified the malaria-causing agent and its various life stages.

Malaria, the Sickness discusses the pathology of malaria, the means for diagnosis, malaria's impact, as well as attempts to control the disease before the vaccine.

The Immunity Alphabet highlights the role of antibodies, cell-mediated immunity and the nature of the immune system.

From Milkmaids to Vaccines describes the development of vaccines against bacteria and viruses.

Fundamental Findings discusses early research on protective vaccines and immune mechanisms carried out using surrogates (principally birds and monkeys) for the disease as it occurs in humans.

Dreams about Vaccines explains how, despite a half century of experimental effor
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Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside
Source:Eurekalert  

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