Navigation Links
Bones mend faster without marrow
Date:4/2/2008

COULD you strengthen bones and speed up recovery after fractures and breaks simply by removing some bone marrow with a syringe?

A new study in rats suggests that the technique could kick-start rapid self-healing in weakened or fractured bones, if followed up with injections of a bone growth hormone.

Agnes Vignerys team at Yale University anaesthetised a group of rats and drilled into the left thigh-bone of each animal before syringing out the bone marrow. Some of the rats received daily doses of parathyroid hormone (PTH), a clinically approved drug that encourages the growth of new bone.

After two weeks, X-rays of the rats showed that new bone had begun to form in the bone marrow cavity. In most rats, the new bone was short-lived - by the third week, marrow began to reappear and any new bone cells were reabsorbed to make room. But in the rats treated with PTH, new bone continued to grow in the cavity into the third week and the marrow did not return.

Vignerys team also discovered that the de-marrowed thighbones of the PTH-treated rats were stronger than their other legs, and the legs of rats not given PTH (Tissue Engineering, DOI: 10.1089/ten.2007.0261).

The study suggests that bone marrow usually inhibits the formation of new bone, says Vignery, and that simply removing the marrow and using drugs to encourage new bone growth could help treat weakened or broken bones.

At first glance this appears counter-intuitive, says Brendon Noble at the University of Edinburgh, UK, since bone marrow generates the stem cells that would usually help repair bones. However, periosteum cells in the membrane that lines the outside of bones also have regenerative powers. Perhaps they are sufficient to take on the role, Noble says.

Bone marrow is also needed to produce new blood cells, but Vignery says that removing it from damaged bones shouldnt affect a persons health, so long as marrow remains in other bones.

Warren Levy of Unigene Laboratories, in Fairfield, New Jersey, which provided Vignerys team with PTH for the study, believes the procedure could radically change the way patients are treated, particularly those with hip fractures. Such fractures often require major surgery, which is expensive and can be life-threatening in elderly patients. Instead, if an X-ray reveals a fracture, you could go in with a needle right there in the doctors suite and do without surgery, Levy says.

The patient would then be sent home with a prescription for PTH, and new bone would grow in the marrow cavity, repairing the fracture from the inside.

Peter Kay of the University of Manchester, UK, agrees that the technique sounds promising. This sort of minimally invasive technique to replace surgery sounds controversial, but if you can strengthen rats bones maybe there is potential. Levy says further animal tests are needed, but they hope to test the technique in humans before the end of the year.


'/>"/>

Contact: Claire Bowles
claire.bowles@rbi.co.uk
44-207-611-1274
New Scientist
Source:Eurekalert

Related medicine news :

1. New IOF Report Shows Smoking, Alcohol, Being Underweight and Poor Nutrition Harm Our Bones
2. Some Female Athletes Risking Weaker Bones
3. High-Trauma Fractures Tied to Weak Bones
4. Diabetes Drug Avandia Could Weaken Bones
5. Dads break bones of children more often than moms
6. Stem cell treatment for brittle bones in the womb
7. Scientists move towards stem cell therapy trials to mend shattered bones
8. Potential brain cancer drug for children may damage bones
9. Potential Brain Cancer Drug for Children May Damage Bones
10. Good luck indeed: 53 million-year-old rabbits foot bones found
11. Experimental Antidepressants Offer Faster Relief
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... More than half of American teens report ... parents report speaking with their child about sex related topics, less than 60 percent ... is proud to announce the launch of its second edition of the “Sexual Wellness” ...
(Date:12/2/2016)... , ... December 02, 2016 , ... Sourced from the ... some unique properties including its unmatched natural purity of just 6 ppm TDS (Total ... crisp. , Nothing Water has been available in several ShopRite and FoodTown stores in ...
(Date:12/2/2016)... ... December 02, 2016 , ... On ... individuals and families from eight different sites throughout Miami-Dade and Broward counties. This ... volunteers worked very hard on Thanksgiving morning by putting together individual meals via ...
(Date:11/30/2016)... ... November 30, 2016 , ... Northridge ... comprehensive in-house dental plan for all patients. Understanding that budget can play a ... patients a number of perks, including discounts on many valuable dental treatments. Options ...
(Date:11/30/2016)... ... November 30, 2016 , ... In recent policy ... focus of public policymakers and system stakeholders in many states. To help them ... Medical Price Index for Workers’ Compensation, Eighth Edition (MPI-WC) . , “If you ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2016  The Addiction Treatment Advisory Group (ATAG), ... Care Pharmacy (AMCP), has released detailed findings on ... opioid addiction crisis, including through improved access to ... ATAG,s newly released paper, "The Role of Managed ... many issues around gaps and barriers to addiction ...
(Date:12/2/2016)... , Dec. 2, 2016 CVS Health ... annual Analyst Day in New York City on Thursday, December 15, 2016, ... Health leadership team will provide an in-depth review of ... shareholder value. The company will also discuss 2017 earnings ... video webcast of the event will be broadcast simultaneously ...
(Date:12/2/2016)...   CytoSorbents Corporation (NASDAQ: CTSO ), ... approved CytoSorb ® cytokine adsorber to treat deadly ... that Dr. Phillip Chan , Chief Executive Officer, ... Main Event investor conference held from December 6 ... Boulevard Hotel in Los Angeles, California ...
Breaking Medicine Technology: