Navigation Links
Bones mend faster without marrow
Date:4/2/2008

COULD you strengthen bones and speed up recovery after fractures and breaks simply by removing some bone marrow with a syringe?

A new study in rats suggests that the technique could kick-start rapid self-healing in weakened or fractured bones, if followed up with injections of a bone growth hormone.

Agnes Vignerys team at Yale University anaesthetised a group of rats and drilled into the left thigh-bone of each animal before syringing out the bone marrow. Some of the rats received daily doses of parathyroid hormone (PTH), a clinically approved drug that encourages the growth of new bone.

After two weeks, X-rays of the rats showed that new bone had begun to form in the bone marrow cavity. In most rats, the new bone was short-lived - by the third week, marrow began to reappear and any new bone cells were reabsorbed to make room. But in the rats treated with PTH, new bone continued to grow in the cavity into the third week and the marrow did not return.

Vignerys team also discovered that the de-marrowed thighbones of the PTH-treated rats were stronger than their other legs, and the legs of rats not given PTH (Tissue Engineering, DOI: 10.1089/ten.2007.0261).

The study suggests that bone marrow usually inhibits the formation of new bone, says Vignery, and that simply removing the marrow and using drugs to encourage new bone growth could help treat weakened or broken bones.

At first glance this appears counter-intuitive, says Brendon Noble at the University of Edinburgh, UK, since bone marrow generates the stem cells that would usually help repair bones. However, periosteum cells in the membrane that lines the outside of bones also have regenerative powers. Perhaps they are sufficient to take on the role, Noble says.

Bone marrow is also needed to produce new blood cells, but Vignery says that removing it from damaged bones shouldnt affect a persons health, so long as marrow remains in other bones.

Warren Levy of Unigene Laboratories, in Fairfield, New Jersey, which provided Vignerys team with PTH for the study, believes the procedure could radically change the way patients are treated, particularly those with hip fractures. Such fractures often require major surgery, which is expensive and can be life-threatening in elderly patients. Instead, if an X-ray reveals a fracture, you could go in with a needle right there in the doctors suite and do without surgery, Levy says.

The patient would then be sent home with a prescription for PTH, and new bone would grow in the marrow cavity, repairing the fracture from the inside.

Peter Kay of the University of Manchester, UK, agrees that the technique sounds promising. This sort of minimally invasive technique to replace surgery sounds controversial, but if you can strengthen rats bones maybe there is potential. Levy says further animal tests are needed, but they hope to test the technique in humans before the end of the year.


'/>"/>

Contact: Claire Bowles
claire.bowles@rbi.co.uk
44-207-611-1274
New Scientist
Source:Eurekalert

Related medicine news :

1. New IOF Report Shows Smoking, Alcohol, Being Underweight and Poor Nutrition Harm Our Bones
2. Some Female Athletes Risking Weaker Bones
3. High-Trauma Fractures Tied to Weak Bones
4. Diabetes Drug Avandia Could Weaken Bones
5. Dads break bones of children more often than moms
6. Stem cell treatment for brittle bones in the womb
7. Scientists move towards stem cell therapy trials to mend shattered bones
8. Potential brain cancer drug for children may damage bones
9. Potential Brain Cancer Drug for Children May Damage Bones
10. Good luck indeed: 53 million-year-old rabbits foot bones found
11. Experimental Antidepressants Offer Faster Relief
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... ... Each year, the American Physical Therapy Association (APTA) offers a Combined Sections ... Center. Almost 10,000 physical therapists across the country are expected to attend this annual ... chosen field and network with their colleagues. As in years past, HydroWorx is ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... Series at Zuckerberg San Francisco General Hospital on April 5-7. The series is ... and create new habits. The workshops cover a broad range of topics, including ...
(Date:2/12/2016)... NC (PRWEB) , ... February 12, 2016 , ... AssureVest ... surrounding areas, is initiating a charity drive that will raise funds earmarked to purchase ... John C. Tayloe Elementary School. , “My school is in a low-income area and ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... of the Pittsburgh metro area, celebrates the beginning of the latest charity campaign ... develop social skills through art. Donations to this worthy cause are currently being ...
(Date:2/12/2016)... ... February 12, 2016 , ... J Thomas & Associates ... it’s commitment to act as Agents of Change in the community, announces a ... homeless families to fulfill immediate needs and help them move into permanent housing. ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... 2016  Memorial Hermann Health System has teamed up ... to bring a one-of-a-kind experience to pediatric patients at ... such as 360-degree video and Google Cardboard, Howard was ... – giving the patients and their families an unexpected, ... caught on video . Memorial Hermann ...
(Date:2/12/2016)... Feb. 12, 2016  Aralez Pharmaceuticals Inc. (Nasdaq: ... the Company will ring the Nasdaq Closing Bell at ... York at 4:00 p.m. ET on Tuesday, ... Adrian Adams , will perform the ... to 4:00 p.m. ET.  A live webcast will be ...
(Date:2/12/2016)... 2016 --> ... Inflammation Global Clinical Trials Review, H2, 2015 provides ... clinical trials landscape along with top level data ... (G7 & E7), Trial Status, Trial Phase, Sponsor ... companies involved and enlists all trials (Trial title, ...
Breaking Medicine Technology: