Navigation Links
Bone marrow transplantation may increase cancer resistance in patients
Date:8/24/2011

LEXINGTON, Ky. (Aug. 23, 2011) Bone marrow transplantation with genetically modified cells may prolong the period of cancer-free survival, suggests a study led by Dr. Vivek Rangnekar, associate director of translational research for the Markey Cancer Center at the University of Kentucky.

Bone marrow, a spongy tissue inside bones, contains stem cells that produce blood cells, including leukocytes, erythrocytes and platelets. In the cover story of the July issue of Cancer Biology & Therapy, Rangnekar and his team explore the transfer of bone marrow from Par-4/SAC-transgenic donor mice to control mice as a means of transferring anti-cancer potential.

Par-4 (also known as PAWR) is a tumor suppressor protein that selectively induces apoptosis in cancer cells, but not normal cells. This function of Par-4 is mediated by its central core domain, SAC. SAC-transgenic mice are resistant to the growth of spontaneous and inducible tumors.

After transplantation, the researchers discovered the expression of cancer-killer SAC-GFP activity in bone marrow cells of the recipient mice, implying the successful transfer and colonization of the anti-cancer tissue from the donors. In addition, soluble Par-4 or SAC protein injected into mice inhibited the growth of metastatic tumors.

Rangnekar, the Alfred Cohen Endowed Chair of Oncology Research at Markey, says the study shows promise for treating both primary and metastatic tumors.

"We are excited by the findings of this study as they indicate that secreted Par-4 is systemically active in mice," Rangnekar said. "Optimization of the bone marrow transplantation procedure using stem cells that are genetically modified to systemically secrete potent protein payloads of Par-4/SAC killer activity may offer a new approach to treat not only primary tumors but also metastatic tumors of diverse origin."


'/>"/>

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
Source:Eurekalert

Page: 1

Related medicine news :

1. Stem cell mobilization therapy found to be safe for bone marrow donors
2. Bone marrow transplant survival more than doubles for young high-risk leukemia patients
3. Gene-modified stem cells help protect bone marrow from toxic side effects of chemotherapy
4. Study reveals origins of a cancer affecting the blood and bone marrow
5. Marrow Donation From Teenage Stranger Saves Mans Life
6. Study identifies drug resistance of CLL in bone marrow and lymph nodes
7. Jefferson study determines bone marrow stromal stem cells may aid in stroke recovery
8. OHSU research suggests compound administered during some bone marrow transplants elevates risks
9. Experimental Drug Shows Promise for Bone Marrow Disorder
10. Selected cells from blood or bone marrow may provide a route to healing blood vessels
11. Effective inducing systems of hepatic differentiation from bone marrow mesenchymal stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... CT (PRWEB) , ... October 13, 2017 , ... ... long-term care services, staged a mock evacuation of the facility as part of a ... Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as ...
(Date:10/13/2017)... Milford, NJ (PRWEB) , ... October 13, 2017 , ... ... weekend at scenic Alexandria Park in Milford, NJ. This free event, sponsored by ... and physical activity. The fun run is geared towards children of all ages; ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the ... save lost souls in the Philippines. “The Journey: From the Mountains to the Mission ... of the Bible. She has taught all ages and currently teaches a class of ...
(Date:10/12/2017)... Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... centers in the U.S., announced today its plans to open a flagship location in ... will occupy the former Rooms To Go store next to Office Depot in the ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017 /PRNewswire/ ... and OptiMed Specialty Pharmacy of Kalamazoo, Mich. ... a strategic hub service that expedites and streamlines patient ... spirometer, Spiro PD 2.0, and wellness management services.  ... a medical device used to measure lung function for ...
(Date:9/13/2017)... --  OrthoAtlanta has been named the official orthopedic and ... for the 2018 College Football Playoff (CFP) National Championship to ... in Atlanta, Georgia . OrthoAtlanta is proud ... participating in many activities leading up to, and including the ... ...
(Date:9/12/2017)... MOUNTAIN LAKES, N.J. , Sept. 12, 2017  Consumer reviews ... Embrace Hearing as the number one company for hearing ... Oticon™, ReSound™ and fifteen other brands. ... Embrace Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that ...
Breaking Medicine Technology: