Navigation Links
Bone marrow-on-a-chip unveiled
Date:5/5/2014

e organs-on-chips in the works. The technology has been recognized internationally for its potential to replace animal testing of new drugs and environmental toxins, and as a new way for scientists to model human disease.

To build organ chips, in the past Wyss teams have combined multiple types of cells from an organ on a plastic microfluidic device, while steadily supplying nutrients, removing waste, and applying mechanical forces the tissues would face in the body. But bone marrow is so complex that they needed a new approach to mimic organ function.

This complexity arises because bone marrow has an integral relationship with bone. Marrow sits inside trabecular bone a solid-looking type of bone with a porous, honeycombed interior. Throughout the honeycomb, conditions vary. Some areas are warmer, some cooler; some are oxygen-rich, others oxygen-starved, and the dozen or so cell types each have their own preferred spots. To add complexity, bone marrow cells communicate with each other by secreting and sensing a variety of biomolecules, which act locally to tell them whether to live, die, specialize or multiply.

Rather than trying to reproduce such a complex structure cell by cell, the researchers enlisted mice to do it.

"We figured, why not allow Mother Nature to help us build what she already knows how to build," said Catherine S. Spina, an M.D.-Ph.D. candidate at Boston University, researcher at the Wyss Institute, and co-lead author of the paper.

Specifically, Wyss Institute Postdoctoral Fellow Yu-suke Torisawa and Spina packed dried bone powder into an open, ring-shaped mold the size of a coin battery, and implanted the mold under the skin on the animal's back.

After eight weeks, they surgically removed the disk-shaped bone that had formed in the mold and examined it with a specialized CAT scanner. The scan showed a honeycomb-like structure that looked identical to natural trabecular bone.

The marrow looked like the real
'/>"/>

Contact: Dan Ferber
dan.ferber@wyss.harvard.edu
617-432-1547
Wyss Institute for Biologically Inspired Engineering at Harvard
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Traumatic Brain Injury (TBI) Legal Resource For People Seeking Legal Options Unveiled at LawsuitLegal.com
2. Mystery of zombie worm development unveiled
3. Adventure Game for Tweens to Promote Healthy Eating will be Unveiled at Games For Health Conference
4. Romantic Paintings, Years in the Making, Unveiled for the First Time
5. Best Fat Burners Unveiled in New Video From Fat Loss Expert
6. New technique to assess the cost of major flood damage to be unveiled at international conference
7. Cancer Prevention, Adjunctive Treatment Plan and Support Program Unveiled at Atlanta Center for Holistic and Integrative Medicine
8. Purple Dresses For Women Just Unveiled By ForeverDresses.com
9. Halter Wedding Dresses Unveiled By FannyBrides.com
10. Party Dress For January 2014 Unveiled By Fadhits.com
11. Beautiful Apple iPhone 5 Hard Cases Unveiled By Skmen.com
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bone marrow-on-a-chip unveiled
(Date:7/31/2015)... ... 2015 , ... Transfinder, a software company based in Schenectady, N.Y., achieved record ... year-over-year for the first six months ended June 30, 2015 compared with the same ... last year’s record-revenue mark of $10.4 million. , “We know what our customers need ...
(Date:7/31/2015)... ... ... Girl Scouts of Historic Georgia and Peach State Health Plan are teaming up ... First" program. Representatives from Peach State Health Plan presented a $10,000 check for the ... parent company, Centene Corporation, are dedicated to raising anti-bullying awareness. We are very proud ...
(Date:7/31/2015)... ... , ... The 2015 ALS Ice Bucket Challenge will officially get underway today ... honor Ice Bucket co-founders Pat Quinn and Pete Frates, the ALS community and Lou ... among the ALS organizations to find treatments and cures for the disease. , ...
(Date:7/31/2015)... ... July 31, 2015 , ... Recently, ... District of Ohio, Western Division (Case No. 3:15-cv-00397) involving the Implanon® contraceptive ... experienced spontaneous migration of their Implanon® implants, inability to locate the implants, unsuccessful ...
(Date:7/31/2015)... ... ... The alarm was ringing. Hugh Chatfield, survivor of a severe 1987 brain injury, almost slept ... equipment was set up to depict the newly poured concrete. With a clear view of ... speaks for itself. Chatfield is also a highly praised safety and drug education speaker/comedian. , ...
Breaking Medicine News(10 mins):Health News:Transfinder Closes First Half of 2015 with Record Revenue 2Health News:Peach State Health Plan Presents $10,000 Check for “Be a Friend First” Anti-Bullying Program to Local Girl Scouts 2Health News:Major League Baseball Joins MDA and Fourteen Other ALS Organizations to Launch ALS Ice Bucket Challenge 2015 2Health News:Major League Baseball Joins MDA and Fourteen Other ALS Organizations to Launch ALS Ice Bucket Challenge 2015 3Health News:Major League Baseball Joins MDA and Fourteen Other ALS Organizations to Launch ALS Ice Bucket Challenge 2015 4Health News:Can Implanon® (Etonogestrel Implant) Go Missing? Zoll, Kranz & Borgess, LLC Files Another Lawsuit on Behalf of Women with Lost or Migrated Implanon® Implants 2Health News:Can Implanon® (Etonogestrel Implant) Go Missing? Zoll, Kranz & Borgess, LLC Files Another Lawsuit on Behalf of Women with Lost or Migrated Implanon® Implants 3
... Scientists have identified a small family of lab-made proteins ... including the H5N1 avian virus, the 1918 pandemic influenza ... antibodies, identical infection-fighting proteins derived from the same cell ... caused by H5N1 and other influenza A viruses. Because ...
... as Charitable Partner for National Initiative as Part of ... NEWPORT NEWS, Va., Feb. 22 The Patient Advocate ... patient services to tens of thousands of patients every ... because of financial or insurance denials - is pleased ...
... 22 Statement of Eliseo Medina and David Regan, Trustees ... Labor Report that the National Labor Relations Board has blocked ... UHW to weaken their former local. The NLRB also ... after learning that the ousted leaders of UHW had failed ...
... have begun to solve some of the mysteries of ... the genetic codes for all the known strains of ... School of Medicine in Baltimore and colleagues at the ... the viruses and assembled them into a "family tree," ...
... better balance in a slippery situation , , FRIDAY, Feb. ... where the footing is unstable helped train them to ... says a University of Illinois at Chicago study. ... develops fall prevention strategies that can be used in ...
... During the annual Promesa y ... leading Spanish-language radio group, Hispanics across the country opened their ... Jude Children,s Research Hospital (R), one of the world,s premier ... Promesa y Esperanza generated more than $6 million ...
Cached Medicine News:Health News:Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu 2Health News:Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu 3Health News:Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu 4Health News:Patient Advocate Foundation Partners with Breakaway from Cancer, Raising Awareness and Funds for Free Services Available to Cancer Patients 2Health News:Patient Advocate Foundation Partners with Breakaway from Cancer, Raising Awareness and Funds for Free Services Available to Cancer Patients 3Health News:Researchers crack the code of the common cold 2Health News:Researchers crack the code of the common cold 3Health News:Researchers crack the code of the common cold 4Health News:Adapting Gait May Help Elderly Avoid Falls 2Health News:Hispanics Across the Country Pledge More Than $6 Million During Univision Radio Event to Help St. Jude Fight Childhood Cancer 2Health News:Hispanics Across the Country Pledge More Than $6 Million During Univision Radio Event to Help St. Jude Fight Childhood Cancer 3
(Date:7/31/2015)... Pa. , July 31, 2015 ... fully integrated specialty pharmaceutical company focused on developing, ... the closing of its previously announced underwritten public ... at a public offering price of $11.25 per ... offering included 1,000,000 shares issued upon the exercise ...
(Date:7/31/2015)... 31, 2015 Magnaquest, a ... data and cloud computing operators has signed a ... giant for Internet of Things (IoT) related initiative. ... on subscription model.      (Logo: ... striving for business innovations to make healthcare services ...
(Date:7/30/2015)... 30, 2015  ResMed Inc. (NYSE: RMD ) ... 2015.  Revenue for the quarter was $453.1 million, a ... 30, 2014 (a 17 percent increase on a constant ... the quarter ended June 30, 2014.  Diluted earnings per ... quarter ended June 30, 2014.  The ...
Breaking Medicine Technology:Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 4Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 3ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 4ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 5ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 6ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 7ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 8ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 9ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 10ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 11ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 12ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 13ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 14ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 15ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 16
... Stereotaxis, Inc. (Nasdaq: STXS ) today ... the Company its 100th patent, a major intellectual property ... the "Method and Apparatus for Dynamic Magnetic Field Control ... commitment to innovate and protect its leading position in ...
... Calif., Sept. 20 Questcor Pharmaceuticals, Inc. (Nasdaq: ... UBS Global Life Sciences Conference on Wednesday, September 22, 2010 ... Bailey, President and Chief Executive Officer, will discuss the Company,s ... Time. Attendance at this conference is by invitation ...
Cached Medicine Technology:Stereotaxis Achieves Intellectual Property Milestone With 100th U.S. Patent 2Stereotaxis Achieves Intellectual Property Milestone With 100th U.S. Patent 3Stereotaxis Achieves Intellectual Property Milestone With 100th U.S. Patent 4
... Tamtron PowerPath is IMPACs comprehensive ... anatomic pathology laboratories to integrate and ... needs through a single, intuitive software ... more than 350 institutions have proven ...
The most compact revolutionary innovation in hematology. 8 or 18 automated parameter hematology analyzer....
... vision controls all refractor operations ... from the wireless remote control. ... can be loaded into the ... transfer. The illuminated LED heads-up ...
... in clinical color vision tests. It is ... or blue/yellow color vision losses that accompany ... Plaquenil, for example), early optic neuritis, glaucoma, ... is fast and accurate in quantifying congenital ...
Medicine Products: