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Bone marrow fat tissue secretes hormone that helps body stay healthy
Date:7/3/2014

onectin, a hormone produced by adipose tissue that helps preserve insulin action. High levels of adiponectin are linked to decreased risk of diabetes and cardiovascular disease. People with obesity have the lowest levels of adiponectin potentially increasing their risk for developing such diseases while the leaner someone gets, the more adiponectin they have.

An outstanding question in the field has been why adiponectin, which is produced by adipose tissue, increases as people lose body fat. A limitation in understanding this paradox is that previous research has focused on peripheral white adipose tissue, which has been believed to be the sole source of adiponectin.

The new study finds however that bone marrow fat tissue which increases as body weight falls is a previously unrecognized source of adiponectin during calorie restriction.

The study found that both marrow adipose tissue and adiponectin increased in humans with anorexia, and in patients undergoing chemotherapy or radiation treatment for ovarian or endometrial cancer. Researchers next used mice to study what happens when marrow fat formation is blocked and also found a relationship between bone marrow adipose tissue and adiponectin, indicating that fat tissue in marrow can have effects beyond the bone.

The research was performed with National Institutes of Health funding in MacDougald's laboratory at the U-M Medical School, and with collaborators including Clifford Rosen, M.D. of Maine Medical; Mark Horowitz, Ph.D., of Yale University, Anne Klibanski, M.D., of Massachusetts General Hospital; Susanta Hui, Ph.D., of University of Minnesota; and Venkatesh (Gary) Krishnan, Ph.D., of Eli Lilly and Company.

"Bone marrow adipose tissue has traditionally had a bad reputation because of its relationship to decreased bone mass but we now know that adipose tissue within marrow goes beyond the bone and also serves as an endocrine organ that can influence metabolism," s
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Contact: Beata Mostafavi
bmostafa@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

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