Navigation Links
Bone marrow cell transplants help nerve regeneration
Date:12/4/2007

Tampa, Fla. (December 4, 2007) A study carried out by researchers at the Kyoto University School of Medicine and published in the current issue of CELL TRANSPLANTATION (Vol.16 No. 8) has shown that when transplanted bone marrow cells (BMCs) containing adult stem cells are protected by a 15mm silicon tube and nourished with bio-engineered materials, they successfully help regenerate damaged nerves. The research may provide an important step in developing artificial nerves.

We focused on the vascular and neurochemical environment within the tube, said Tomoyuki Yamakawa, MD, the studys lead author. We thought that BMCs containing adult stem cells, with the potential to differentiate into bone, cartilage, fat, muscle, or neuronal cells, could survive by obtaining oxygen and nutrients, with the result that rates of cell differentiation and regeneration would improve.

Nourished with bioengineered additives, such as growth factors and cell adhesion molecules, the BMCs after 24 weeks differentiated into cells with characteristics of Schwann cells a variety of neural cell that provides the insulating myelin around the axons of peripheral nerve cells. The new cells successfully regenerated axons and extended their growth farther across nerve cell gaps toward damaged nerve stumps, with healthier vascularity.

The differentiated cells, similar to Schwann cells, contributed significantly to the promotion of axon regeneration through the tube, explained Yamakawa. This success may be a further step in developing artificial nerves.

Grafting self-donated (autologous) nerve cells to damaged nerves has been widely practiced and considered the gold standard. However, autologous cells for transplant are in limited supply. Allologous cells, donated by other individuals, require the host to take heavy immunosuppressant drugs.

Artificial nerves, cultured from a variety of cells and transplanted to nerve damaged areas, have been considered as alternatives to nerve grafting. However, prior to this research, cells cultured for this purpose have generally not been very successful in regenerating axons with sufficient vascularity or length to bridge nerve gaps.

This technique for implanting BMCs containing adult stem cells at damaged nerve sites as employed by the Kyoto researchers has opened up new possibilities for nerve regeneration, said Paul Sanberg, PhD, D.Sc., Distinguished Professor at University of South Florida Health and co-editor-in-chief of Cell Transplantation.


'/>"/>

Contact: Ryosuke Kakinoik
kakino@kuhp.kyoto-u.ac.jp
81-757-513-657
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related medicine news :

1. StemCor Systems Receives FDA Clearance for Bone Marrow Harvesting System
2. Study on Plasma-Depleted Cord Blood Transplantation Receives Best Abstract Award From The National Marrow Donor Program
3. Oral drug sets a new survival standard for bone marrow cancer
4. National Foundation for Transplants to Expand Program Providing Hotel Accommodations to Patient Families
5. New Heart Pump Helps Women Awaiting Transplants
6. Blood-incompatible infant heart transplants safe, may save more lives
7. Blood-Incompatible Heart Transplants Safe for Infants
8. Lung Transplants May Not Help Most Cystic Fibrosis Children
9. Alcohol may amplify chronic rejection in lung transplants
10. Consumer Reports Analysis: Drugs for Nerve Pain, Fibromyalgia Effective, But Not Always Best
11. Cell-surface sugar defects may trigger nerve damage in multiple sclerosis patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... ... February 21, 2017 , ... Hanna Boys ... at PolicyLink, will be the keynote speaker at its second Professional Networking Breakfast ... Color Framework, which develops comprehensive strategies to create and expand opportunities for boys ...
(Date:2/21/2017)... ... February 21, 2017 , ... Individuals ... problems directly related to surgery, treatment, therapy and management. Regular exercise in proper ... qualities of life despite their diseases. On February 23, 2017, 1:00-2:00 p.m. E.S.T., ...
(Date:2/21/2017)... ... February 21, 2017 , ... ... coverage in veterinary medicine, will be launching its first bi-monthly issue of 2017 ... medicine, business and practice management, and One Health. , In making the ...
(Date:2/21/2017)... ... February 21, 2017 , ... Atlanta-based ... predictive analytic firm Predixion’s Healthcare IT practice. Predixion, which raised $42M+ to date, ... by giants including Accenture, GE Ventures, and Software AG , will bring ...
(Date:2/21/2017)... ... February 21, 2017 , ... A February 6 article on Healio ... It found that the treatments have led to significant improvements in weight loss and ... efforts. It also noted very few problematic results relating to the treatment. Beverly Hills ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... IBM ) Research has today announced new research developments ... retina. The Melbourne based IBM researchers ... in retina images, which could in the future offer doctors ... who may be at risk of eye diseases – such ... world. The research began in 2015 and ...
(Date:2/21/2017)... 21, 2017  Luminex Corporation (NASDAQ: LMNX ) ... authorized the initiation of a quarterly cash dividend to its ... dividend will be payable on April 14, 2017 to shareholders ... 24, 2017. The board of directors intends ... of $0.06 to holders of its common stock, representing a ...
(Date:2/21/2017)... NEW YORK , Feb. 21, 2017 /PRNewswire/ ... healthcare industry. This technique is allowing a previously ... and simplicity. Due to this ability, it is ... will cross US$ 4 Billion by 2022. The ... driven by advancements in computing platforms, rising installation ...
Breaking Medicine Technology: