Navigation Links
Bone implant offers hope for skull deformities
Date:11/19/2009

A synthetic bone matrix offers hope for babies born with craniosynostosis, a condition that causes the plates in the skull to fuse too soon. Implants replacing some of the infant's bone with the biodegradable matrix could eliminate some of the operations currently used to treat the condition.

"The remarkable thing about this is the finding that the composition of the matrix changes what the cells around it do. Cells begin producing natural drugs to drive bone healing in direct response to the composition of the bone matrix," said Kent Leach, professor of biomedical engineering at UC Davis.

The material is currently being tested in experiments with rats. Human trials will depend upon the success of tests in animals.

The human skull is not a smooth dome, but a patchwork of fused bones that resembles a soccer ball rather than an egg. At birth, the skull contains 45 separate pieces, joined by connective tissue, that slowly fuse together into solid bone. In most babies, this process keeps pace with brain growth, resulting in a normally shaped head.

However, one in every 2,000 babies is born with craniosynostosis, where the plates fuse and the skull becomes rigid. This leaves less room for the brain to grow, leading to developmental disabilities, and cranial and facial deformities.

In the standard surgery, surgeons remove fused bones, break them up and reposition some of the pieces along the edges to protect the brain. This usually slows the bone growth and allows the brain to grow. Nevertheless, 6 to 8 percent of babies will need a second operation and 25 percent of those will need yet a third operation.

Leach believes that the environment surrounding the cells might be sending the wrong instructions, causing cells to grow wrong. Leach's biodegradable implant is impregnated with stem cells from bone marrow and a synthetic version of hydroxyapatite, a chemical produced naturally in the body to stimulate bone growth. Once implanted, bone-forming cells enter the matrix. Leach's research with rats shows dense connective tissue, suggestive of bone formation, only eight weeks after implantation.

Leach hopes that his new matrix will encourage the growth of healthy tissue and eliminate the need for second and third surgeries. "The matrix will resorb over time, leaving only the child's own bone," he said.


'/>"/>

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis
Source:Eurekalert

Related medicine news :

1. Nanowire coating for bone implants, stents
2. Latest DES Analysis Stresses Importance of Physicians Well-Trained in Implantation Technique and Patient Follow-Up
3. Innocoll Agrees the Sale of its CollaRx(R) GENTAMICIN SURGICAL IMPLANT and European Sales and Marketing Infrastructure to EUSA Pharma
4. Implantable device designed to detect, stop seizures under study at MCG
5. AtriCure Reports First Human Implant of the Cosgrove-Gillinov Left Atrial Appendage Occlusion System
6. Bone-growing nanomaterial could improve orthopaedic implants
7. RFID Implant Cancer Questions Concern Patients
8. GrantAdler Shipping Novel Implantable Vascular Access Port
9. SBi Launches rHead(TM) Lateral Radial Head Implant and rHead(TM) Plating Systems to Expand its Elbow Management System
10. Facet Solutions AFRS(TM) Implant Demonstrates Positive Clinical Results After One Year Follow Up
11. TyRx Pharma, Inc. Announces Presentation of Results to Benefit Women with Breast Implants (In-Vivo Efficacy Study Regarding AIGISRx DEB) at the Plastic Surgery 2007 Meeting on October, 28 2007 in Baltimore, MD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... ... 2016 , ... Comfort Keepers® of San Diego, CA is excited to announce ... program to drive cancer patients to and from their cancer treatments. Comfort Keepers ... of life and ongoing independence. Getting to and from medical treatments is one ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
(Date:6/24/2016)... , June 24, 2016  Global Blood Therapeutics, ... company developing novel therapeutics for the treatment of ... announced the closing of its previously announced underwritten ... at the public offering price of $18.75 per ... were offered by GBT. GBT estimates net proceeds ...
(Date:6/24/2016)... The Academy of Managed Care Pharmacy (AMCP) ... would allow biopharmaceutical companies to more easily share health ... and coverage decisions, a move that addresses the growing ... The recommendations address restrictions in the sharing of ... label, a prohibition that hinders decision makers from accessing ...
Breaking Medicine Technology: