Navigation Links
Bone implant offers hope for skull deformities
Date:11/19/2009

A synthetic bone matrix offers hope for babies born with craniosynostosis, a condition that causes the plates in the skull to fuse too soon. Implants replacing some of the infant's bone with the biodegradable matrix could eliminate some of the operations currently used to treat the condition.

"The remarkable thing about this is the finding that the composition of the matrix changes what the cells around it do. Cells begin producing natural drugs to drive bone healing in direct response to the composition of the bone matrix," said Kent Leach, professor of biomedical engineering at UC Davis.

The material is currently being tested in experiments with rats. Human trials will depend upon the success of tests in animals.

The human skull is not a smooth dome, but a patchwork of fused bones that resembles a soccer ball rather than an egg. At birth, the skull contains 45 separate pieces, joined by connective tissue, that slowly fuse together into solid bone. In most babies, this process keeps pace with brain growth, resulting in a normally shaped head.

However, one in every 2,000 babies is born with craniosynostosis, where the plates fuse and the skull becomes rigid. This leaves less room for the brain to grow, leading to developmental disabilities, and cranial and facial deformities.

In the standard surgery, surgeons remove fused bones, break them up and reposition some of the pieces along the edges to protect the brain. This usually slows the bone growth and allows the brain to grow. Nevertheless, 6 to 8 percent of babies will need a second operation and 25 percent of those will need yet a third operation.

Leach believes that the environment surrounding the cells might be sending the wrong instructions, causing cells to grow wrong. Leach's biodegradable implant is impregnated with stem cells from bone marrow and a synthetic version of hydroxyapatite, a chemical produced naturally in the body to stimulate bone growth. Once implanted, bone-forming cells enter the matrix. Leach's research with rats shows dense connective tissue, suggestive of bone formation, only eight weeks after implantation.

Leach hopes that his new matrix will encourage the growth of healthy tissue and eliminate the need for second and third surgeries. "The matrix will resorb over time, leaving only the child's own bone," he said.


'/>"/>

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis
Source:Eurekalert

Related medicine news :

1. Nanowire coating for bone implants, stents
2. Latest DES Analysis Stresses Importance of Physicians Well-Trained in Implantation Technique and Patient Follow-Up
3. Innocoll Agrees the Sale of its CollaRx(R) GENTAMICIN SURGICAL IMPLANT and European Sales and Marketing Infrastructure to EUSA Pharma
4. Implantable device designed to detect, stop seizures under study at MCG
5. AtriCure Reports First Human Implant of the Cosgrove-Gillinov Left Atrial Appendage Occlusion System
6. Bone-growing nanomaterial could improve orthopaedic implants
7. RFID Implant Cancer Questions Concern Patients
8. GrantAdler Shipping Novel Implantable Vascular Access Port
9. SBi Launches rHead(TM) Lateral Radial Head Implant and rHead(TM) Plating Systems to Expand its Elbow Management System
10. Facet Solutions AFRS(TM) Implant Demonstrates Positive Clinical Results After One Year Follow Up
11. TyRx Pharma, Inc. Announces Presentation of Results to Benefit Women with Breast Implants (In-Vivo Efficacy Study Regarding AIGISRx DEB) at the Plastic Surgery 2007 Meeting on October, 28 2007 in Baltimore, MD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... four time Emmy award winner and inspirational speaker Jan Fox will serve as ... by Speaking Boldly will provide participants with tools to more effectively communicate with ...
(Date:2/10/2016)... ... 10, 2016 , ... For additional information contact Phyllis Strupp 480-488-5858 , Brain ... Age: The Ultimate Guide to Brain Training" by award-winning author Phyllis Strupp ... date is March 16, 2016. A free review copy is available to the ...
(Date:2/10/2016)... West Palm Beach, Florida (PRWEB) , ... February ... ... Golf & Country Club) announced that it has been awarded the prestigious Distinguished ... of the World award program conducted by BoardRoom magazine, one of the most ...
(Date:2/10/2016)... Middleboro, MA (PRWEB) , ... February 10, 2016 ... ... of their revolutionary, biocompatible columns and accessories. These PEEK-lined stainless steel (PLS) columns ... to provide a solution that ensures the integrity of biological samples while operating ...
(Date:2/10/2016)... ... ... Workrite Ergonomics this week announced the launch of the Conform Monitor Arm Series, ... was to develop a product from the ground up that would provide the most ... Hulsey, Product Manager for Workrite Ergonomics. “The Conform series features a wide variety ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... Feb. 10, 2016  CVS Health (NYSE: CVS ... in Santa Clara County, CA , ... the Santa Clara University campus. CVS Pharmacy stores and ... patients against the disease. Students at Santa Clara University ... vaccinated. In addition, anyone who has had close contact ...
(Date:2/10/2016)... Feb. 10, 2016 Immune Pharmaceuticals Inc. (NASDAQ: ... today that it has filed a patent application directed ... cancers. --> --> ... administration of Ceplene (histamine dihydrochloride) in combination with immune ... predicting the efficacy of Ceplene and IL-2 therapy in ...
(Date:2/10/2016)... TOKYO , Feb. 10, 2016  Astellas Pharma ... , "Astellas") announced today that it has successfully completed, ... a tender offer to purchase all issued and outstanding ... OCAT, President and CEO: Paul Wotton , "Ocata") ... the stockholder in cash ("Tender Offer"). Astellas commenced the ...
Breaking Medicine Technology: