Navigation Links
Bone from blood: Circulating cells form bone outside the normal skeleton, Penn study finds
Date:7/23/2009

PHILADELPHIA The accepted dogma has been that bone-forming cells, derived from the body's connective tissue, are the only cells able to form the skeleton. However, new research shows that specialized cells in the blood share a common origin with white blood cells derived from the bone marrow and that these bloodstream cells are capable of forming bone at sites distant from the original skeleton. This work, published online this month in the journal Stem Cells, represents the first example of how circulating cells may contribute to abnormal bone formation.

The discovery that circulating blood cells can form bone outside the normal skeleton was made while studying a rare genetic disease of misplaced bone growth, fibrodysplasia ossificans progressiva, or FOP.

"Identifying circulating cells with bone-forming potential in humans has important implications for FOP, as well as more common disorders where bone is formed outside the skeleton, such as in end-stage aortic valve disease, following head and spinal cord injury, and after hip and knee replacements," says senior author Robert J. Pignolo, MD, PhD, Assistant Professor of Medicine at the University of Pennsylvania School of Medicine. "This type of aberrant bone growth also occurs after severe trauma, such as blast injuries suffered by Iraqi war veterans, and its study may help us understand how bone forms after the development of the skeleton has ceased, with possible applications in bone diseases where only scarce or poor quality bone forms." Pignolo is also the Director of the Ralston-Penn Clinic for Osteoporosis & Related Bone Disorders

The researchers analyzed blood samples from patients with FOP and unaffected individuals, isolating cells that could form bone when transplanted subcutaneously into animals. The isolated cells were characterized using surface and other markers, which identified them as being derived from bone marrow. The researchers also examined tissue from FOP patients that had formed new bone, and found that these cells had migrated into the early sites of the lesion.

"This study provides an explanation for how bone-forming cells could seed sites of injury and inflammation that subsequently develop ossifications outside the skeleton," says Frederick S. Kaplan, MD, Isaac & Rose Nassau Professor of Orthopedic Molecular Medicine and Director of the Center for FOP & Related Disorders at Penn. "Dr. Pignolo and researchers in his lab demonstrated that these circulating cells are able to home to damaged tissue."


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Related medicine news :

1. Battling Bacteria in the Blood: U-M Researchers Tackle Deadly Infections
2. Circulating fats kill transplanted pancreas cells, study shows
3. FDA Clears Cellsearch(TM) Circulating Tumor Cell Test for Monitoring Metastatic Prostate Cancer Patients
4. High circulating D-dimers are associated with presence of ascites
5. Circulating Tumor Cells Reveal Insights Into Lung Cancers
6. Circulating tumor cells can reveal genetic signature of dangerous lung cancers
7. Levels of Circulating Tumor Cells Could Predict Prostate Cancer Outcome
8. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
9. Brain cells work differently than previously thought
10. Embryonic Stem Cells Repair Human Heart
11. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bone from blood: Circulating cells form bone outside the normal skeleton, Penn study finds
(Date:3/28/2017)... , ... March 28, 2017 , ... Usually, the impending ... daily wardrobe. However, for those self-conscious about a double chin, this means more anxiety ... ideal solution. , “For most people, a double chin is undesirable,” Dr. Goldman ...
(Date:3/28/2017)... ... March 28, 2017 , ... Award-winning medical ... begin serving as new board chair for Orange County health care system CalOptima ... remainder of soon-to-be former chair Mark Refowitz’s term, which runs through June 30 ...
(Date:3/28/2017)... ... March 28, 2017 , ... With less than 10,000 dermatologists in ... quality care can be limited while the desire to conquer breakouts and eliminate skincare ... care for every customer online, today released its inaugural survey on the State of ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... The Executives, ... to raise money to for the Toys for Tots Literacy Campaign at their Semi-Annual ... in excess of $70 billion, the U.S. ranks at number 14 internationally in literacy. ...
(Date:3/28/2017)... CA (PRWEB) , ... March 28, 2017 , ... ... which will be offered by the American Association of Integrative Medicine and available ... for healthcare providers at the AutismOne 2017 Conference in Colorado Springs. , Ed ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... LONDON , March 27, 2017 ... require to better understand Bayer and its partnering interests and ... since 2010 report provides an in-depth insight into the partnering ... On demand company reports are prepared upon purchase ... and company data. The report will be delivered ...
(Date:3/27/2017)... , March 27, 2017  Cryoport, Inc. (NASDAQ: ... it intends to offer shares of common stock in ... statement on file with the Securities and Exchange Commission ... other conditions, and there can be no assurance as ... or as to the actual size or terms of ...
(Date:3/27/2017)...  A new survey from the American ... Bidding Program (CBP) significantly reduced beneficiary choice and access ... choice forces beneficiaries to switch to unfamiliar or unsuitable ... AADE,s survey is the latest in a ... out the inherent problems with the CBP. Last year, ...
Breaking Medicine Technology: