Navigation Links
Bone drug zoledronic acid may help prevent spread of early lung cancer
Date:2/25/2011

A drug that is currently used to help treat bone metastases in patients with lung cancer could also be useful at an earlier stage of treatment, to prevent the cancer from spreading in the first place, Italian researchers have found.

Dr Michela Quirino and colleagues from the Catholic University of the Sacred Heart in Rome have reported important new evidence that zoledronic acid may be able to prevent lung cancer metastases from recruiting the new blood vessels they need to survive. This process of recruiting new blood vessels is called angiogenesis.

"Our investigation represents the first clear clinical evidence of the anti-angiogenic effect of zoledronic acid in patients with metastatic lung cancer," Dr Quirino said. "It also represents the first biological basis in lung cancer for the clinical investigation of zoledronic acid not only for metastatic lung cancer, but also in early disease."

Dr Quirino presented findings from a study of 41 patients with advanced lung cancer.

Each patient was administered 4 mg of zoledronic acid, and their blood levels of several molecular markers of angiogenesis were measured before and 48 hours after the injection. Those markers included the molecules VEGF, PDGF, b-FGF and HGF.

"We found a statistically significant reduction of VEGF levels at day 2 after 4 mg ZA intravenous infusion compared with basal values," Dr Quirino said. Blood levels of bFGF were also significantly reduced. "Some studies reported that VEGF secretion is induced by bFGF and this could support our results," she added.

The researchers did not record any significant effect of injecting the drug on the levels of the other two mediators of angiogenesis, PDGF and HGF.

Treatment with zoledronic acid is already an important treatment to manage bone metastases from lung cancer, Dr Quirino noted. Some clinical studies have already demonstrated that zoledronic acid in bone metastases from lung cancer im
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Vaccine May Prevent TB in People With HIV
2. Prevention Is Key Research Goal for Premature Babies, Scientists Say
3. Hormone May Prevent Aggressive Breast Cancer
4. Pet Dental Month Prime Time To Schedule Preventive Annual Cleaning For Pets
5. Botox May Prevent Some Migraines
6. Medical Nurse Training, Inc. Partners With Healthcare Companies to Develop Corporate Branded, Accredited Programs for Patient/Bed Safety and Fall Prevention/Protection
7. VIDEO from Medialink and AAFA: Asthma PSA Reinforces Prevention of Asthma Symptoms
8. Northern California Cancer Center Changes Name to Cancer Prevention Institute of California
9. New Safety Bath and Sill Mats Help Prevent Slip and Fall in Bathrooms - from Martinson-Nicholls
10. Sacred Heart Medical Center Cited for Violation of Safety Standards in H1N1 Prevention
11. African-Americans attitudes about lung cancer may hinder prevention
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... Plugin and template developers from Pixel ... for Final Cut Pro X. , “TransPack Volume 5 gives ... pull off an industry professional look” Said Christina Austin, CEO ... TransPack Volume 5, a new level of professionalism will become ... over 50 Final Cut Pro X transitions featuring organic animations. ...
(Date:12/26/2014)... December 26, 2014 DW-InductionHeating.com (DaWei Induction ... designing, researching and developing, producing and marketing of a ... the business announces their new series of induction ... of the company, induction brazing refers to ... special filler material and heat. The manager says that ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 “Every three months the trends for ... sweetheart evening dress will be one of the hottest styles ... Yunx.co.uk says. Today, the company releases 26 A-line sweetheart evening ... 80% off. , “We are trying our best to ... our latest designs. Along with affordable prices, we provide discounted ...
(Date:12/25/2014)... 2014 Recently, BellasDress has ... its wedding dresses. BellasDress has chosen their best-selling lace ... choices for the holiday season. , Now, BellasDress.com ... wedding gowns here at discount prices. The business hopes ... its website. , “All our elegant products ...
Breaking Medicine News(10 mins):Health News:Today a new plugin was announced from Pixel Film Studios, TransPack Volume 5 for Final Cut Pro X 2Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2
... suggests that a urine test can help in both ... raises the possibility of treating these with anti-angiogenesis drugs ... Pediatrics, has published an article about vascular anomalies in ... of newly born infants and include both vascular malformations ...
... gambling behavior may share their personality// profiles with substance ... been able to identify personality traits of problem gambling ... those of substance abusers. Researchers in their research have ... problem gambling behavior may not represent the entire gamut ...
... recent research paper on chronic obstructive pulmonary disease ... useful for patients of this disease to have ... pulmonary disease (COPD) are lung diseases involving restricted ... inflammation, air sac enlargement etc. some common forms ...
... that it will promote a culture of openness and ... vision, FDA will create a new independent Drug Safety ... issues, and will provide emerging information to health providers ... ,Specific proposals for immediate and fundamental steps to ...
... journal Epidemiology has published a major retrospective study that indicates ... is associated infertility. ,Dr. Louise A. Brinton, of ... 12,193 U.S. women treated for infertility between 1965 and ... of the general population. The women were followed for a ...
... a short term a single drug may be used to ... ,Bipolar disorder is a psychotic disorder characterized by successive feelings ... affects 3 to 4 5 of the global adult population. ... have multiple occurrences of the condition for most of their ...
Cached Medicine News:Health News:Simple Urine Test Can Help To Monitor Disfiguring Birthmarks, 2Health News:Monitoring Drug Safety 2
(Date:12/24/2014)... 2014  Lockton Dunning Benefits, the ... the addition of Vice President Kim Foerster ... Pharmacy Consulting team, Excelsior Solutions. ... to the position.  Most recently, she worked as ... Specialty Pharmacy, where she has held various managerial ...
(Date:12/24/2014)... 23, 2014 In response to urgent requests from the ... Sierra Leone , Direct Relief delivered two 10-bed ... the treatment of local health workers who contract Ebola while ... Ebola care center was constructed for foreign health care workers ... available for local Sierra Leonean health workers. With ...
(Date:12/22/2014)... 2014  CytoSorbents Corporation (OTCQB:CTSOD), a critical care ... technology to help fight deadly inflammation in critically-ill ... today announced the appointment of Dr. Gregory ... Senior Vice President of Clinical Development, effective January ... Russo is an accomplished pediatric cardiothoracic surgeon ...
Breaking Medicine Technology:Kim Foerster Joins Lockton Companies 2First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5
... Reportlinker.com announces that a new ... its catalogue:   ... Africa Endoscopy Devices Market Outlook to ... Endoscopy Visualization Systems, Capsule Endoscope Systems ...
... SAN DIEGO, May 3, 2012 Aethlon Medical, ... authored by its Chairman and CEO, Jim Joyce. ... 19th of last year, we introduced and began marketing ... the capabilities of plasma membrane technology and affinity drug ...
Cached Medicine Technology:Middle East and Africa Endoscopy Devices Market Outlook to 2017 - Flexible Endoscopes, Rigid Endoscopes, Endoscopy Visualization Systems, Capsule Endoscope Systems and Others 2Middle East and Africa Endoscopy Devices Market Outlook to 2017 - Flexible Endoscopes, Rigid Endoscopes, Endoscopy Visualization Systems, Capsule Endoscope Systems and Others 3Middle East and Africa Endoscopy Devices Market Outlook to 2017 - Flexible Endoscopes, Rigid Endoscopes, Endoscopy Visualization Systems, Capsule Endoscope Systems and Others 4Middle East and Africa Endoscopy Devices Market Outlook to 2017 - Flexible Endoscopes, Rigid Endoscopes, Endoscopy Visualization Systems, Capsule Endoscope Systems and Others 5Middle East and Africa Endoscopy Devices Market Outlook to 2017 - Flexible Endoscopes, Rigid Endoscopes, Endoscopy Visualization Systems, Capsule Endoscope Systems and Others 6Middle East and Africa Endoscopy Devices Market Outlook to 2017 - Flexible Endoscopes, Rigid Endoscopes, Endoscopy Visualization Systems, Capsule Endoscope Systems and Others 7Middle East and Africa Endoscopy Devices Market Outlook to 2017 - Flexible Endoscopes, Rigid Endoscopes, Endoscopy Visualization Systems, Capsule Endoscope Systems and Others 8Middle East and Africa Endoscopy Devices Market Outlook to 2017 - Flexible Endoscopes, Rigid Endoscopes, Endoscopy Visualization Systems, Capsule Endoscope Systems and Others 9Middle East and Africa Endoscopy Devices Market Outlook to 2017 - Flexible Endoscopes, Rigid Endoscopes, Endoscopy Visualization Systems, Capsule Endoscope Systems and Others 10Middle East and Africa Endoscopy Devices Market Outlook to 2017 - Flexible Endoscopes, Rigid Endoscopes, Endoscopy Visualization Systems, Capsule Endoscope Systems and Others 11Middle East and Africa Endoscopy Devices Market Outlook to 2017 - Flexible Endoscopes, Rigid Endoscopes, Endoscopy Visualization Systems, Capsule Endoscope Systems and Others 12Middle East and Africa Endoscopy Devices Market Outlook to 2017 - Flexible Endoscopes, Rigid Endoscopes, Endoscopy Visualization Systems, Capsule Endoscope Systems and Others 13Aethlon Medical Note: Fiscal Year Revenue Guidance 2Aethlon Medical Note: Fiscal Year Revenue Guidance 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: