Navigation Links
Bone drug suppresses wandering tumor cells in breast cancer patients
Date:6/2/2010

The bone-strengthening drug zoledronic acid (Zometa) can help fight metastatic breast cancer when given before surgery, suggests research at Washington University School of Medicine in St. Louis.

When the drug was given along with chemotherapy for three months before breast cancer surgery, it reduced the number of women who had tumor cells in their bone marrow at the time of surgery.

The study was published in the May issue of The Lancet Oncology.

Every day, tumors shed thousands of cells, which spread throughout the body and are referred to as disseminated tumor cells (DTCs). Breast cancer DTCs often lodge in bone marrow where bone growth factors help them survive.

Chemotherapy can increase bone turnover and bone growth factors, potentially exacerbating the problem of DTCs in the bone, which can resurface later to cause metastatic disease in cancer patients.

"Bone marrow seems to be a DTC sanctuary, allowing them to adapt and disseminate to different organs, where they're a leading cause of death," says study leader Rebecca Aft, MD, PhD, associate professor of surgery and a breast cancer specialist at the Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine. "We believe that zoledronic acid inhibits the release of growth factors that help support the growth of DTCs."

Zoledronic acid is generally prescribed to reduce and delay bone complications due to multiple myeloma and bone metastases from solid tumors. Two recent studies showed that zoledronic acid improves disease-free survival when used along with estrogen-lowering therapy before breast cancer surgery. Estrogen-lowering therapy, like chemotherapy, potentially increases bone loss.

In this randomized phase II clinical trial, researchers split 109 women with newly diagnosed stage II or stage III breast cancer into two groups. The control group received chemotherapy alone, while the other received a combination treatment of chemotherapy and zoledronic acid.

After three months of therapy, patients with DTCs in their bone marrow decreased from 43 percent to 30 percent in the combination group, compared with a decrease from 48 percent to 47 percent in the control group. This result approached statistical significance.

The researchers also found that of those patients who had no DTCs in their bone marrow at the start of the study, 87 percent remained negative after three months of combination treatment compared to 60 percent of those who received chemotherapy alone, a result that was statistically significant.

Zoledronic acid treatment with chemotherapy had additional benefits. Women in the combination group experienced significant gains in bone density after 12 months. This is helpful for breast cancer patients, who often develop osteoporosis as a side effect of chemotherapy and other breast cancer treatments.

The study also suggested that zoledronic acid may help fight certain types of breast tumors directly. Aft speculates that the drug may stop the tumor from making its own blood supply, modify the immune system in a way that makes it harder for tumor cells to survive or even cause the cancer cells to commit suicide.

"Although it's common practice to administer zoledronic acid during chemotherapy given after breast cancer surgery, it isn't common when chemotherapy is given before surgery," Aft says. "Because chemotherapy increases bone loss, we would argue that women should receive zoledronic acid at the time of chemotherapy in the presurgical setting. Our single-institutional study also suggests that similar protocols using zoledronic acid for high-risk breast cancer patients should continue to be tested in larger, multi-institutional studies."


'/>"/>

Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert  

Related medicine news :

1. FreightWatch Security Net Launches Solution for Tracking and Rescuing Persons at Risk of Wandering
2. Spice Compounds May Stem Tumor Growth
3. New Scan May Help Find Aggressive Prostate Tumors
4. CSHL study identifies potential way to reverse cancer cell metabolism and tumor growth
5. American Brain Tumor Association names Alexander Ksendzovsky outstanding 2009 medical student
6. Scientists show how brain tumors outsmart drugs
7. Researchers find a treatment for deadly brain tumor
8. Cancer stem cells suppress immune response against brain tumor
9. Florida Brain Tumor Association & Moffitt Cancer Center Presents: The Bridge to Hope
10. Diffusion tensor imaging increases ability to remove benign tumors in children
11. Minimally invasive surgery removes sinus tumor without facial disfiguration
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bone drug suppresses wandering tumor cells in breast cancer patients
(Date:2/13/2016)... ... February 13, 2016 , ... The National ... the leading national organization representing the growing community of recovering individuals (now over ... include Family Recovery in policies addressing addiction. , Although many of the ...
(Date:2/13/2016)... ... February 13, 2016 , ... Many individuals looking to lead a healthy ... of reasons. IsoPasta by Isolator Fitness has delved into this niche allowing those ... the high-carb repercussions. IsoPasta has 30 grams of protein and only 7 grams ...
(Date:2/13/2016)... ... February 13, 2016 , ... With FCPX Overlay Embers from Pixel Film Studios ... Cut Pro X. Each user can select from up to 40 effect overlays. With ... focus offset, hue, saturation, value, contrast, glow, and more all within a click of ...
(Date:2/13/2016)... ... February 13, 2016 , ... The producers of Enterprises ... businesses. , The increasingly modern world of instantaneous consumption proves very convenient for ... sources such as oil and coal, which pollutes our air, water, and soil. It ...
(Date:2/13/2016)... ... 2016 , ... In its newly released Infusion Therapy Standards ... be used to ensure patient safety when placing an IV catheter. A key ... use of vein visualization technology in patients with difficult venous access or after ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... 12, 2016  Clinical Affairs leaders at pharmaceutical organizations are looking ... of the world. While some companies have conducted a significant number ... activity in countries such as India and ... and India are now requiring local ... countries. --> China and ...
(Date:2/12/2016)... , Feb. 12, 2016   National Community Pharmacists ... RPh, MBA issued the following statement today in response ... by the Centers for Medicare & Medicaid Services ... NCPA, beneficiary advocates and others: patient advocacy ... are still reviewing the full CMS analysis. Our initial ...
(Date:2/12/2016)...  This month,s issue of the Journal of ... in-depth look at various causes and consequences associated with rising health ... which has generated significant public outrage and calls for ... E. Happe , PharmD, MPH. --> JMCP ... --> In 2014 prescription drug spending in ...
Breaking Medicine Technology: