Navigation Links
Bone complications due to cystic fibrosis have a genetic cause, according to an MUHC study
Date:2/7/2008

Montreal, 6 February 2008 - A recent study by Dr Christina Haston, a researcher of the McGill University Health Centre research Institute, sheds some new light on the bone problems that generally accompany cystic fibrosis. Dr Hastons study is pointing at genetics as contributing to this bone frailty, a finding which may have some implications in changing therapeutic practices. The article was published on February 1, 2008 in the American Journal of Respiratory and Critical Care Medicine.

The medical community generally considers the bone fragility associated with cystic fibrosis to be multifactorial. It is thought to be a consequence of the mutation of the Cftr gene, the gene responsible for cystic fibrosis, of the pancreatic disease associated with cystic fibrosis and of the treatment with steroids to facilitate breathing.

The study showed that mice with a Cftr gene mutation have a bone mineral density and bone mass that are significantly lower than those of control mice. This difference occurs without the pancreatic insufficiency seen clinically and in the absence of steroid treatment.

This conclusion clearly defines cystic-fibrosis-related bone problems as an additional pathology stemming from the Cftr mutation and not as a side effect of treatment. This may have some therapeutic consequences as it opens an avenue for defining a targeted treatment in mice.

Although the precise mechanism that links this mutation to bone development is unknown, studying these mice at different ages corresponding to childhood, adolescence and adulthood has shown that the bone structures of mice with the Cftr mutation get closer to the norm as the mice age; in other words, the genetic mutation seems to just slow bone growth and not prevent it. However, this partial conclusion requires further study to be confirmed.


'/>"/>

Contact: Isabelle Kling
isabelle.kling@muhc.mcgill.ca
514-934-1934
McGill University Health Centre
Source:Eurekalert

Page: 1

Related medicine news :

1. Black Men Most at Risk for Kidney Disease Complications
2. Taking more than 1 anti-inflammatory drug may lead to complications
3. The Reality of Pregnancy in Sub-Saharan Africa: Author Shares Truth About Pregnancy in a Region Where 1 in 16 Women Die from Complications
4. Study links blood transfusions to surgery complications in women
5. Plastic Surgery Complications and Deaths are Rare, Despite Highly Publicized Death of Donda West
6. Study reveals high death toll after severe urinary complications in men over 45
7. Testing delays cause severe AIDS complications, Einstein researchers find
8. For some diabetics, burden of care rivals complications of disease
9. Most patients who have male-to-female sex-change surgery are happy, despite complications
10. Study shows insurance status, not race, linked to complications in patients with acute appendicitis
11. Drug fights cystic fibrosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, ... truth and expose popular lies regarding proper relationships according to the bible. ... into the core of the subject by explaining why certain types of sexual relationships ...
(Date:7/2/2015)... ... 02, 2015 , ... sweetFrog Enterprises, LLC. is pleased to announce the opening of its newest ... Lone Star State. The premium frozen yogurt chain was listed as #22 on the Inc. ... in the Village at Bachman Lake, is located at:, 3701 W. Northwest Highway, STE 430, ...
(Date:7/2/2015)... ... July 02, 2015 , ... ... retrofit project at the University of Minnesota, they knew it would save the ... also be an award-winning choice: the total energy savings after installation was an ...
(Date:7/2/2015)... ... July 02, 2015 , ... “ LIFX ” was featured on NewsWatch ... products available to consumers. Amanda Forstrom, a technology expert and special reporter for NewsWatch, ... versatile smart light bulbs on the market. , According to the U.S. Department of ...
(Date:7/2/2015)... ... July 02, 2015 , ... Six months ahead of his 80th birthday, ... raise awareness and money for the Pulmonary Hypertension Association (PHA). Stevenson began the ... near Washington, D.C. by mid-September. He left Glasgow, Mont. yesterday morning and is making ...
Breaking Medicine News(10 mins):Health News:Yisrayl Hawkins Explains What the Bible Really Says about Sex in New Publication This Week 2Health News:sweetFrog Opens 18th Location in the Lone Star State 2Health News:Kenall’s TekDek™ Helps University Achieve Award-Winning Energy Savings in Parking Structure Lighting Retrofit 2Health News:The Most Versatile Smart Light Bulbs were featured on NewsWatch Television 2Health News:79-Year-old ‘Pacing Parson’ Passes 1,000-Mile Mark in Cross-Country Walk for Pulmonary Hypertension Association 2Health News:79-Year-old ‘Pacing Parson’ Passes 1,000-Mile Mark in Cross-Country Walk for Pulmonary Hypertension Association 3
... in an attempt to find out how various eating ... the blood pressures of meat eaters, fish eaters, vegetarians, ... Health Nutrition, showed how healthy eating habits could help ... in the comparative study - some with high blood ...
... on birth control pills have been linking them to ... pills. However, a new study published by Walter Spitzer, ... contradicted previous studies by stating that women who take ... no increased risk for heart attack compared to women ...
... observed a pill-sized camera and a CT scan may prove ... small intestine. The newly approved camera capsule, also known as ... before available. A patient swallows the pill and, for eight ... on the person's abdomen.// The pictures can then be viewed ...
... have discovered that it might be possible for tear-free GM ... the chemical in onions that makes you cry is not ... of Tokyo and Kyoto University,//tested the theory that the crying ... Alliinase plays a part in the chemical reactions that give ...
... that cloned animals tend to harbor genetic defects that ... the rational that reproductive cloning of humans should be ... be used safely for therapeutic cloning techniques, such as ... Parkinson's to diabetes. Cloned animals have major ...
... shown in a new study, that soy can lower cholesterol ... studies give more reason to dish up the soy protein ... fatty acids, which are found in abundance in fish, //flax ... health benefits. But researchers suggest they also produce physiological effects ...
Cached Medicine News:Health News:Cut meat to cut blood pressure 2Health News:No heart attack risk for women taking birth control pills 2Health News:Genetic failure in cloned animals 2Health News:Soy, Omega 3s convalesce artery health 2Health News:Soy, Omega 3s convalesce artery health 3
(Date:7/3/2015)... , Mexique, July 3, 2015 ... cible les épidémies que sont l,hypertension, le diabète ... l,intermédiaire de plateformes éducatives gratuites et d,une conférence ... (Photo: http://photos.prnewswire.com/prnh/20150630/227033 ) , ... en ligne , Prendre en charge l,hypertension ...
(Date:7/3/2015)... MUMBAI , July 3, 2015 /PRNewswire/ ... gab heute bekannt, vorbehaltlich bestimmter Abschlussbedingungen eine ... Russland erworben zu haben. Mit dieser Übernahme ... der mit einem Umsatz von 765 Mrd. ... größten Pharmamärkten der Welt gehörte (IMS Health). ...
(Date:7/3/2015)... STOCKHOLM , July 3, 2015 ... agreement with Broda Technologies Co., Ltd., operating in both ... use the company,s proprietary IntelliGel ® supramolecular hydrogel ... under development and other ophthalmic therapies. The Broda technology ... polymer solution is a free-forming liquid and with low ...
Breaking Medicine Technology:Lutter contre trois maladies chroniques majeures en Amérique latine grâce à la formation médicale 2Lutter contre trois maladies chroniques majeures en Amérique latine grâce à la formation médicale 3Lupin übernimmt Biocom aus Russland 2Lupin übernimmt Biocom aus Russland 3Redwood Pharma Licenses Novel Hydrogel Drug Delivery Technology From Broda Technologies 2
... Pa., Aug. 19 Particle Sciences Inc. ... and,pilot production capabilities with the installation of ... core of the pilot line,comprising a Haake ... enables the production of high-quality drug loaded ...
... samples to be used to identify molecular,signature of ... ALS Therapy,Development Institute (ALS TDI) announced today ... samples collected through an expanded network,of clinical partnerships. ... effort to indentify the altered expression of genes,and ...
Cached Medicine Technology:Particle Sciences Expands Its Combination Product Capabilities 2ALS Therapy Development Institute Partners with Clinical Centers to Establish Pathological Mechanisms of Lou Gehrig's Disease 2ALS Therapy Development Institute Partners with Clinical Centers to Establish Pathological Mechanisms of Lou Gehrig's Disease 3
They employ Lea Symbols. Contrast levels are the same at 25%, 10%, 5%, 2.5% and 1.25%. Each offers a different set of Lea Symbols to guard against memorization. Also uses recording forms (P/N 215400)...
Binkhorst Hook (Left) 2.5 mm wide J Shape (0.64 mm x 25 mm)....
McIntyre-Binkhorst, length 18 mm....
Set of 2. Double-ended. 15 mm x 21 mm and 15 mm x 42 mm blades. Hand-held. Most popular model or size....
Medicine Products: