Navigation Links
Bone complications due to cystic fibrosis have a genetic cause, according to an MUHC study
Date:2/7/2008

Montreal, 6 February 2008 - A recent study by Dr Christina Haston, a researcher of the McGill University Health Centre research Institute, sheds some new light on the bone problems that generally accompany cystic fibrosis. Dr Hastons study is pointing at genetics as contributing to this bone frailty, a finding which may have some implications in changing therapeutic practices. The article was published on February 1, 2008 in the American Journal of Respiratory and Critical Care Medicine.

The medical community generally considers the bone fragility associated with cystic fibrosis to be multifactorial. It is thought to be a consequence of the mutation of the Cftr gene, the gene responsible for cystic fibrosis, of the pancreatic disease associated with cystic fibrosis and of the treatment with steroids to facilitate breathing.

The study showed that mice with a Cftr gene mutation have a bone mineral density and bone mass that are significantly lower than those of control mice. This difference occurs without the pancreatic insufficiency seen clinically and in the absence of steroid treatment.

This conclusion clearly defines cystic-fibrosis-related bone problems as an additional pathology stemming from the Cftr mutation and not as a side effect of treatment. This may have some therapeutic consequences as it opens an avenue for defining a targeted treatment in mice.

Although the precise mechanism that links this mutation to bone development is unknown, studying these mice at different ages corresponding to childhood, adolescence and adulthood has shown that the bone structures of mice with the Cftr mutation get closer to the norm as the mice age; in other words, the genetic mutation seems to just slow bone growth and not prevent it. However, this partial conclusion requires further study to be confirmed.


'/>"/>

Contact: Isabelle Kling
isabelle.kling@muhc.mcgill.ca
514-934-1934
McGill University Health Centre
Source:Eurekalert

Page: 1

Related medicine news :

1. Black Men Most at Risk for Kidney Disease Complications
2. Taking more than 1 anti-inflammatory drug may lead to complications
3. The Reality of Pregnancy in Sub-Saharan Africa: Author Shares Truth About Pregnancy in a Region Where 1 in 16 Women Die from Complications
4. Study links blood transfusions to surgery complications in women
5. Plastic Surgery Complications and Deaths are Rare, Despite Highly Publicized Death of Donda West
6. Study reveals high death toll after severe urinary complications in men over 45
7. Testing delays cause severe AIDS complications, Einstein researchers find
8. For some diabetics, burden of care rivals complications of disease
9. Most patients who have male-to-female sex-change surgery are happy, despite complications
10. Study shows insurance status, not race, linked to complications in patients with acute appendicitis
11. Drug fights cystic fibrosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... The annual time frame to change Medicare health ... is ending December 7th. Currently-enrolled Medicare beneficiaries who are looking to switch from their ... D) need to make changes during this period order for their new policy to ...
(Date:12/2/2016)... ... December 02, 2016 , ... With the number of ... of an injury, patients must find the one that works for them. When an ... created a machine that worked and decided to share it with others. , He ...
(Date:12/2/2016)... ... December 02, 2016 , ... Dr. Raffi ... be included in the 2016 “Guide to America’s Top Plastic Surgeons” for seven ... amalgamation of their education, experience, and professional associations. , One the most ...
(Date:12/2/2016)... ... December 02, 2016 , ... Mediaplanet is proud ... Today, which covers the innovative treatments, therapeutic technologies, and revolutionized nutrition that are ... are prolonging life 6 years in the last 3 decades,” says Dr. Valentine ...
(Date:12/2/2016)... ... December 02, 2016 , ... The ... Waikiki Beach Resort and Spa in Honolulu, offering local frontline clinicians the opportunity ... management. , The demand for supplemental training related to pain management has ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... plc (NYSE: AGN ), a leading global pharmaceutical ... Share Repurchase (ASR) Program. Logo - http://photos.prnewswire.com/prnh/20150612/222796LOGO ... , , ... Company entered into a variable tenor ASR arrangement on  November ... of its ordinary shares. Approximately 40.5 million shares worth $8 ...
(Date:11/30/2016)... -- Research and Markets has announced the ... Neurosurgical and Monitoring Devices 2017 - MedView" report to ... , ... report suite on the U.S. market for neurological devices includes ... monitoring devices, detachable coils, liquid embolics, catheters, guidewires, balloon occlusion ...
(Date:11/30/2016)... Varian Medical Systems (NYSE: VAR ... Company in the Healthcare Equipment and Services industry, according ... "JUST 100 List." The rankings are based on criteria ... on attitudes towards corporate behavior, involving 50,000 Americans over ... companies against their peers within 32 major industries. The ...
Breaking Medicine Technology: