Navigation Links
Bone cells' branches sense stimulation, when to make new bone
Date:7/20/2010

SAN ANTONIO (July 20, 2010) A long-standing question in bone biology has been answered: It is the spindly extensions of bone cells that sense mechanical stimulation and signal the release of bone-growth factors, according to research from The University of Texas Health Science Center at San Antonio.

The study, reported this week in Proceedings of the National Academy of Sciences of the United States of America, offers an important clue for developing therapies to treat the bone-thinning disease osteoporosis and bone loss associated with aging, said Jean Jiang, Ph.D., senior corresponding author from the Department of Biochemistry, UT Health Science Center Graduate School of Biomedical Sciences.

Sensitive extensions

"Osteocytes are the most abundant cells in bone," Dr. Jiang said. "In the field of bone biology, there was a long-standing debate as to which part of the osteocyte senses mechanical loading. In this study, we demonstrate for the first time that it is the extensions, which are called dendrites."

Regular physical exercise is highly beneficial in maintaining bone health and in prevention of bone loss and osteoporosis. Mechanical stimulation of the bone through weight bearing is critical for promoting bone remodeling, said Sirisha Burra, Ph.D., lead author from the Department of Biochemistry.

"Maintenance of bone health depends on the osteocytes' ability to sense the stimulation," Dr. Burra said. "If osteocytes lose this ability, it could possibly lead to diseases such as osteoporosis. Hence, it is important to understand this mechanism."

Mechanical impact

The Health Science Center collaborated with Southwest Research Institute in San Antonio to estimate the mechanical impact of force applied to the dendrites. Magnitudes of mechanical stress were determined.

"Understanding how bone cells sense and respond to mechanical signals within the skeleton is an inherently multidisciplinary problem," said co-author Daniel P. Nicolella, Ph.D., institute engineer in the Mechanics and Materials Section at Southwest Research Institute. "We determined the mechanical stresses applied to the osteocytes in these experiments so that they can be compared to the mechanical signals predicted to occur within the skeleton during routine physical activities."

Toll of osteoporosis

Approximately 8 million women and 2 million men have osteoporosis in the U.S. Affected bone becomes brittle and can fracture with minor falls. In severe cases, a bone can even break from a sneeze. Another 34 million Americans are estimated to have low bone mass and are at higher risk for osteoporosis. (Source: National Osteoporosis Foundation http://www.nof.org/osteoporosis/diseasefacts.htm)

Bone loss has been observed in astronauts who have spent a long time in space. Greater understanding of the process of bone remodeling could also aid in the discovery of solutions for the degenerative joint disease osteoarthritis.

Intriguing idea

Apart from its clinical implications, the study is intriguing because it "brings in a novel thought that different parts of a single cell can have different material and sensory properties," Dr. Jiang said. "Different parts of the cell can react differently to the same stimulus. This is a very important fact to consider while studying cellular signaling and regulatory mechanisms."


'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert

Related medicine news :

1. Breast cancer cells regulate multiple genes in response to estrogen-like compounds
2. UCLA scientists create army of tumor-fighting immune cells and watch as they attack cancer
3. New E-Commerce Website for Spectroscopy Cuvettes and Other Precise Optical Products Launched by NSG Precision Cells
4. Scientists reprogram triple-negative breast cancer cells to respond to tamoxifen
5. CELLING Treatment Centers New Clinic Revolutionizes Spinal Care with Adult Stem Cells
6. Fat cells play key role in development of type 2 diabetes
7. Researchers identify factors behind blood-making stem cells
8. Cancer stem cells are not 1 size fits all, lung cancer models show
9. Study shows how dietary supplement may block cancer cells
10. Chromosomal variations found in early passage female embryonic stem cells
11. Fructose sugar makes maturing human fat cells fatter, less insulin-sensitive
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset ... of specialty vendors and unique items from across the nation, this holiday-themed event will ... services offered by the VNA. The boutique will be open Saturday, November 4 ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented ... the lowdown on sciatica in a new episode of "Success Files," which is ... events and innovation and investigates each subject in-depth with passion and integrity. , ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... services for healthcare compliance program management, will showcase a range of technology and ... for Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
(Date:10/12/2017)... LOS ANGELES (PRWEB) , ... October 12, 2017 ... ... of Parsa Mohebi Hair Restoration, has recently contributed a medical article to the ... doctors, on cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... Oct. 4, 2017  South Korean-based healthcare product Development ... aide "cprCUBE" on Kickstarter. The device will educate the ... arrests with better efficiency compared to the dated and ... feedback on efficacy of the compression for a more ... a goal to raise $5,000. ...
(Date:10/2/2017)... 2017  AllianceRx Walgreens Prime, the combined central specialty ... pharmacy benefit manager Prime Therapeutics LLC (Prime), today officially ... the unveiling of new signage at its headquarters in ... at a few other company-owned facilities across the country. ... some of whom will begin to see the AllianceRx ...
(Date:9/27/2017)... MIAMI , Sept. 27, 2017  Commended for their ... recent notable awards. Ranked as number one in the South ... ninth time in Inc. 5000 yearly list, the national specialty ... CEO, Armando Bardisa will soon be honored by ... Set to receive his award ...
Breaking Medicine Technology: