Navigation Links
Bone Disease Test Shows Death Risk for Dialysis Patients
Date:7/31/2008

High alkaline phosphatase levels boosted mortality 25% in chronic kidney cases

THURSDAY, July 31 (HealthDay News) -- High levels of alkaline phosphatase -- a routinely measured marker of bone disease -- may signal an increased risk of death among patients receiving dialysis for chronic kidney disease, say U.S. researchers.

The study analyzed data on almost 74,000 hemodialysis patients during a three-year period. It found that patients with alkaline phosphatase levels above the upper limit of normal (>120 IU/L) had a 25 percent higher death rate. This association was significant across various subgroups of patients.

The study also found that patients whose alkaline phosphatase level increased during the first six months of the study were at higher risk over the subsequent two-and-one-half years.

The findings were expected to be published in the November issue of the Journal of the American Society of Nephrology.

"This large epidemiological study shows, for the first time, a consistent and robust association between a high blood level of alkaline phosphatase and cardiovascular death in thousands of dialysis patients across the United States," researcher Dr. Kamyar Kalantar-Zadeh, of the University of California, Los Angeles, said in an American Society of Nephrology news release.

"If the association between alkaline phosphatase and mortality has a causal link, treatment strategies that reduce alkaline phosphatase levels may improve survival in patients with CKD [chronic kidney disease] and probably in many other patients with chronic diseases and active bone disorders," Kalantar-Zadeh said.

Alkaline phosphatase levels are routinely measured in dialysis patients to monitor for metabolic bone disease, a common complication of CKD. However, current guidelines don't include specific recommendations or targets for alkaline phosphatase levels in patients.

"In dialysis patients, increased levels of alkaline phosphatase in the blood indicate a so-called high-turnover bone disease, which can happen due to hormonal imbalance in CKD," said Kalantar-Zadeh, who added that previous studies have identified a possible link between bone disease and cardiovascular health in CKD patients.

"Alkaline phosphatase has recently been shown to be associated with increased vascular calcification in experimental studies. Our study shows the clinical manifestation of this association in real-world patients," he said.

More information

The American Academy of Family Physicians has more about chronic kidney disease.



-- Robert Preidt



SOURCE: American Society of Nephrology, news release, July 30, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Smoking may strongly increase long-term risk of eye disease
2. Pot bellies linked to early signs of cardiovascular disease
3. Anemia and tropical diseases; Is pharmacogenomics ready for the clinic?
4. Radiologists encouraged to look beyond cancer for clinically unseen diseases
5. Use of certain lipid measures not more effective in predicting coronary heart disease
6. Role seen for cannabis in helping to alleviate allergic skin disease
7. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
8. Effectiveness of mouse breeds that mimic Alzheimers disease symptoms questioned
9. New research shows how chronic stress worsens neurodegenerative disease course
10. A new molecular zip code, and a new drug target for Huntingtons disease
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, and ... in the eye of the beholder, according to experts who offered insights and commentary ... of Managed Care. For the full issue, click here . , For the ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are ... with endometriosis. These women need a treatment plan to not only alleviate symptoms ... can help for preservation of fertility and ultimately achieving a pregnancy. The specialists ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the largest ... as the Medical Director of its new Mesquite-Samuell Farm facility. , “We are ... Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published ... unfamiliar with. The article goes on to state that individuals are now more comfortable ... less common operations such as calf and cheek reduction. The Los Angeles area medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Dialysis Devices Global Market - Forecast to 2022" report ... is the treatment method for the patients with kidney failure, ... and excess fluid from the patient,s blood and thus the ... sodium, potassium and chloride in balance. Increasing ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic ... Coating, Parenteral) - Global Forecast to 2021" report ... The global pharmaceutical excipients market is projected to ... of 6.1% in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: