Navigation Links
Bone Disease Test Shows Death Risk for Dialysis Patients
Date:7/31/2008

High alkaline phosphatase levels boosted mortality 25% in chronic kidney cases

THURSDAY, July 31 (HealthDay News) -- High levels of alkaline phosphatase -- a routinely measured marker of bone disease -- may signal an increased risk of death among patients receiving dialysis for chronic kidney disease, say U.S. researchers.

The study analyzed data on almost 74,000 hemodialysis patients during a three-year period. It found that patients with alkaline phosphatase levels above the upper limit of normal (>120 IU/L) had a 25 percent higher death rate. This association was significant across various subgroups of patients.

The study also found that patients whose alkaline phosphatase level increased during the first six months of the study were at higher risk over the subsequent two-and-one-half years.

The findings were expected to be published in the November issue of the Journal of the American Society of Nephrology.

"This large epidemiological study shows, for the first time, a consistent and robust association between a high blood level of alkaline phosphatase and cardiovascular death in thousands of dialysis patients across the United States," researcher Dr. Kamyar Kalantar-Zadeh, of the University of California, Los Angeles, said in an American Society of Nephrology news release.

"If the association between alkaline phosphatase and mortality has a causal link, treatment strategies that reduce alkaline phosphatase levels may improve survival in patients with CKD [chronic kidney disease] and probably in many other patients with chronic diseases and active bone disorders," Kalantar-Zadeh said.

Alkaline phosphatase levels are routinely measured in dialysis patients to monitor for metabolic bone disease, a common complication of CKD. However, current guidelines don't include specific recommendations or targets for alkaline phosphatase levels in patients.

"In dialysis patients, increased levels of alkaline phosphatase in the blood indicate a so-called high-turnover bone disease, which can happen due to hormonal imbalance in CKD," said Kalantar-Zadeh, who added that previous studies have identified a possible link between bone disease and cardiovascular health in CKD patients.

"Alkaline phosphatase has recently been shown to be associated with increased vascular calcification in experimental studies. Our study shows the clinical manifestation of this association in real-world patients," he said.

More information

The American Academy of Family Physicians has more about chronic kidney disease.



-- Robert Preidt



SOURCE: American Society of Nephrology, news release, July 30, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Smoking may strongly increase long-term risk of eye disease
2. Pot bellies linked to early signs of cardiovascular disease
3. Anemia and tropical diseases; Is pharmacogenomics ready for the clinic?
4. Radiologists encouraged to look beyond cancer for clinically unseen diseases
5. Use of certain lipid measures not more effective in predicting coronary heart disease
6. Role seen for cannabis in helping to alleviate allergic skin disease
7. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
8. Effectiveness of mouse breeds that mimic Alzheimers disease symptoms questioned
9. New research shows how chronic stress worsens neurodegenerative disease course
10. A new molecular zip code, and a new drug target for Huntingtons disease
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... August 19, 2017 , ... Parker at Stonegate, an assisted ... passionate employees, caregivers, volunteers, thought leaders, researchers, educators and partners leading the way ... time to refresh the carpeting with the goal of maintaining the same precise ...
(Date:8/18/2017)... , ... August 18, 2017 , ... More than 20,000 ... Republic of Congo (DRC) thanks to an ambitious venture that conjoined the passions of ... the generous support of the Liberty community. These shoes will save lives from the ...
(Date:8/18/2017)... ... August 18, 2017 , ... August 18, 2017 — Mediaplanet ... for active, healthy lifestyles and highlighting the importance of proactive eye and ear ... and shares the latest innovations in hearing aid technology. , According to ...
(Date:8/18/2017)... McLean, VA (PRWEB) , ... August 18, 2017 ... ... offers asset protection services and financial consultations to communities throughout the greater DC ... Semper K9 with the goal of rescuing local animals and training them to ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Brian Gifford Agency, ... Indiana, is campaigning in support of Campagna Academy in a charity drive to provide ... “Hoosier Boys’ Town of Indiana,” Campagna Academy is a nonprofit organization that has offered ...
Breaking Medicine News(10 mins):
(Date:8/17/2017)... 2017 MJAC2017 , the premier cannabis event ... today reveals its leading lineup. MJAC2017 ... cannabis innovator specializing in the development of pharmaceutical and consumer ... Rambridge™ and The Green Organic Dutchman are gold sponsors for ... silver sponsors. ...
(Date:8/15/2017)... , Aug. 15, 2017   Mostyn Law and Gulf ... Houston, Texas . The Mostyn Law family ... 2 years. That is why Mostyn Law is partnering ... to show its appreciation. Blood supplies are running ... 5% short of hospital needs in August. That is why the ...
(Date:8/15/2017)... , Aug. 15, 2017 AccuGenomics, Inc., a ... , today announced that the company has provided an ... of North Carolina at Chapel Hill and to Qura ... to characterize and quantify HIV reservoir and viral expression ... intervention. The HIV Cure Center is a joint initiative ...
Breaking Medicine Technology: