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Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations
Date:8/3/2009

1-3 adverse events were vomiting, nausea, diarrhea, anorexia and abdominal pain.(7)

Updated efficacy and safety data from this study demonstrated that patients with an ECOG performance status of 0-1 had a median overall survival of 264 days (n=56).(7) These data suggest that BIBF 1120 has single-agent activity in patients suffering from recurrent NSCLC.(7) Preliminary data from this study were presented in April 2008 at the 1st European Lung Cancer Conference in Switzerland.

The data presented at WCLC, and the Phase III development of its two most advanced compounds, mark significant progress for Boehringer Ingelheim's evolving oncology pipeline. In addition to BIBW 2992 and BIBF 1120, Boehringer Ingelheim has several oncology compounds in earlier clinical and pre-clinical development.

Boehringer Ingelheim believes in evidence-based, scientific progress; its extensive oncology clinical trial program involves more than 800 study centers in 47 countries. Boehringer Ingelheim has a dedicated cancer research center in Vienna where scientists are focused on the discovery and development of new treatments to combat or alleviate the symptoms of cancer.

Clinical trial information

Additional information on the LUX-Lung 3 trial is available by calling the Boehringer Ingelheim toll-free number, 1-800-243-0127.

The global LUME-Lung Phase III clinical trial program is investigating BIBF 1120 in combination with standard second-line chemotherapy in patients with advanced NSCLC. The studies are ongoing with a recruitment target of 2,600 patients worldwide. This is one of the largest Phase III study programs in an advanced NSCLC patient population to date.(8,9)

About Lung Cancer

Lung cancer is the world's most common cancer and kills more people than any other cancer.( )In 2008, approximately 1.52 million new cases of lu
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