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Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations
Date:8/3/2009

d adverse events were Grade 3 and included diarrhea, skin-related adverse events and mouth ulcerations.(4) Comparable response rates (66%) and disease control rates (97%) were observed in the second-line setting.(4)
  • Preliminary data from another study showed that BIBW 2992 improved disease symptoms and reduced the size of tumors in three heavily pre-treated patients with HER2neu mutations.(5) Results from this trial warrant further investigation of BIBW 2992 as a potential new treatment option for NSCLC patients who have HER2neu mutations.(6)
  • On May 29, Boehringer Ingelheim announced that it entered into an agreement with the Manchester, UK-based company DxS to provide a companion diagnostic test kit for BIBW 2992 to identify mutations of the EGFR in patients with NSCLC. Under the terms of the agreement, DxS and Boehringer Ingelheim will work jointly to make a suitable companion diagnostic test kit globally available.

    Data for BIBF 1120 in NSCLC

    Also presented at the conference were results from a pharmacokinetic analysis of another Boehringer Ingelheim compound, BIBF 1120, an angiogenesis inhibitor that simultaneously inhibits vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR) and fibroblast growth factor receptors (FGFR). The data presented at the conference come from a Phase II study investigating the efficacy and safety of the compound in patients with relapsed advanced NSCLC.(7) This double-blind multicenter trial included patients with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 with relapsed NSCLC after failure of first- or second-line chemotherapy.(7)

    The analysis showed that the pharmacokinetics of BIBF 1120 are independent from patient characteristics (e.g., age, weight, height, gender, smoking status, etc.).(7) The most common (greater than 10%) Grades
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