Navigation Links
Body's own veins provide superior material for aortic grafts
Date:12/30/2009

DALLAS Dec. 30, 2009 A vascular surgical technique pioneered at UT Southwestern Medical Center and designed to replace infected aortic grafts with the body's own veins has proved more durable and less prone to new infection than similar procedures using synthetic and cadaver grafts.

Aortic graft infections are one of the most serious complications in patients undergoing aortic grafting procedures for peripheral arterial disease (PAD) and aortic aneurysms. PAD reduces blood circulation in the pelvis and lower extremities, and aortic aneurysms result in a weakening of the aortic wall that can cause lethal rupture of the aorta, the largest artery in the body. Patients with PAD and aortic aneurysms often require surgery, and aortic grafting procedures using synthetic grafts are typically the first line of treatment.

For patients with PAD, the procedure restores blood circulation to the legs, and for patients with aneurysm, it replaces the weakened aortic wall and prevents rupture. Synthetic grafts made of Dacron, a polyester material, are placed in the aorta and femoral arteries in the abdomen and groin, which feed blood to the legs. But in about 1 percent to 2 percent of these patients, the grafts become infected a complication that causes amputation and death if left untreated.

Dr. G. Patrick Clagett, chief of vascular surgery at UT Southwestern, pioneered a technique called the neo-aortoiliac system (NAIS) that repairs these aortic-graft infections. The procedure involves removing the infected graft and replacing it with sections of femoral-popliteal veins harvested from the patient's thighs, rather than another synthetic graft or vessels harvested from human cadavers.

In a recent study published in the Journal of Vascular Surgery, Dr. Clagett and his team reported on 187 patients at UT Southwestern treated for aortic graft infections who underwent the NAIS procedure from 1990 to 2006. It is the largest group of such patients ever studied, and the researchers found that the incidence of re-infection was lower and the procedure resulted in superior durability with much lower long-term amputation rates when compared with other operations to treat this condition.

"This operation has gained favor worldwide in the treatment of this devastating condition," said Dr. Clagett. "Since performing the first operation here in the 1990s, we have accumulated data over the years and have found this procedure to be far superior in overall patient outcomes."

Simply replacing the old Dacron graft with a new synthetic graft can result in devastating infection of the new one, said Dr. Clagett, who is immediate past president of the Society for Vascular Surgery. His team and others also have found that the new synthetic or cadaver grafts tend to develop clots and new blockages.

"When we use the patient's own tissue to construct a new graft, it provides an advantage because they are less likely to form clots within the graft and less likely to develop new blockages," Dr. Clagett said. "Patients also need fewer subsequent procedures, a common problem with the other treatments for this complication."

He added that patients who have the NAIS procedure don't need to be on lifelong antibiotic therapy. Because the aortic reconstruction is fashioned with the patient's own tissue, there is no foreign material that is prone to re-infection.


'/>"/>

Contact: Katherine Morales
katherine.morales@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. World-Renowned Vascular Surgeon to Conduct Training at Harvard Medical School Site on Non-Invasive Treatment of Veins
2. New Web Site on Varicose Veins is Launched by AngioDynamics at American College of Phlebology Congress
3. Endovenous Laser Therapy Used for Treatment of Varicose Veins
4. BUSM researchers identify better laser for treating facial spider veins
5. Steroid Restores Vision When Veins in Eye Become Blocked
6. Garden of Life Launches Lovely Legs(TM) to Reduce Visible Signs of Varicose and Spider Veins
7. The Gift of Life Flows Through Your Veins!
8. Varicose Veins Pose Scary Health Risk; Sufferers Find Solace With Insurance-Covered Treatment at Renaissance Laser and Vein Institute
9. US Market for Minimally Invasive Treatment of Varicose Veins to Rise to More than $215 Million by 2013
10. Statin Might Help Fight Blood Clots in Veins
11. Video: CRESTOR(R) Reduced Risk of Blood Clots in the Veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2017)... ... February 20, 2017 , ... ... range of emergency dental care at his office, Antoine Dental Center. Emergency dentistry ... dental emergencies, they are at risk for serious complications and often experience severe ...
(Date:2/20/2017)... ... February 20, 2017 , ... Chuck E. Cheese’s® and Center for ... joint event at Chuck E. Cheese’s locations throughout New England, New York and New ... opportunity to experience the fun of visiting Chuck E. Cheese’s in a sensory-friendly environment. ...
(Date:2/20/2017)... ... February 20, 2017 , ... ... to purchase a new ultrasound-enhanced thrombolysis machine, a state-of-the-art device that breaks up ... facilitated by the Pepin Family Foundation. , “We greatly appreciate this gift from ...
(Date:2/19/2017)... ... February 19, 2017 , ... Braun Industries will be participating as an ... event will take place February 23-25, 2017 at the Calvin L. Rampton Salt Palace ... with three new ambulances on display. , “JEMS is a leader ...
(Date:2/19/2017)... ... February 19, 2017 , ... "At your fingertips" electronic access ... and the Delaware Health Information Network (DHIN) have partnered to improve connectivity of ... health information exchange, DHIN stores and shares real-time health data for more than ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... 2017 Research and Markets has announced the addition ... report to their offering. ... report provides separate comprehensive analytics for the US, Canada ... Asia-Pacific , and Rest of World. Annual estimates and forecasts ... analysis is provided for these markets. Market data and analytics are derived ...
(Date:2/17/2017)... 2017  In partnership with CitiHope , ... , The Jack Brewer Foundation (JBF Worldwide) ... dollars, worth of medicine to Innovating Health International ... a non-profit dedicated to treating chronic diseases and addressing women,s ... Haiti and providing these medicines ...
(Date:2/17/2017)... YORK , Feb. 17, 2017  BioDigital, ... today the partnership of their 3D body mapping ... healthcare IT.  The new integration will be used ... an interactive model of the human body. BioDigital ... saves clinicians time, while also increasing the precision ...
Breaking Medicine Technology: