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Body Mass Index may serve as prognostic tool for advanced, aggressive breast cancers
Date:3/13/2008

ght, said Cristofanilli.

"Of course, it's important to explore interventions to prevent overall obesity. These outcomes may have a major impact not only on the incidence of future breast cancer patients, but on their long-term outcome," Cristofanilli said.

"From a research standpoint, we really need to further look at the relationship between obesity and some endocrine factors that may explain why inflammatory breast cancer patients are more frequently obese, for example. Our next step is to go back to the lab and start looking into those specific factors related to obesity in breast cancer - insulin, estrogen levels and leptin are areas of immediate interest."

Cristofanilli acknowledged that dietary intervention might be difficult for women undergoing chemotherapy; however, some change of lifestyle habits for overweight and obese patients after diagnosis are vital.

Cristofanilli noted that before BMI is completely accepted as a prognostic tool for breast cancer, prospective trials and endocrinology studies must be conducted. However, to oncologists currently treating overweight and obese LABC and IBC patients, Cristofanilli recommends they be more aggressive in follow-up, including considering more frequent physical exams and imaging studies.


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Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

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