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Body Mass Index may serve as prognostic tool for advanced, aggressive breast cancers
Date:3/13/2008

iagnosed inflammatory breast cancer patients were overweight or obese, and IBC is associated with a poor prognosis. The idea was to understand the etiological link between the most aggressive forms of breast cancers and, ultimately, with prognosis."

For the retrospective study, researchers reviewed 606 patients - 495 (82 percent) with LABC and 111 (18 percent) with non-metastatic IBC. All were enrolled in clinical protocols at M. D. Anderson between 1974 and 2000. The median follow up was six years for all patients; for women still alive, the median follow-up was 9.9 years.

In calculating BMI, 208 (34 percent) of the patients were normal or underweight, 194 (32 percent) were overweight and 204 (34 percent) were obese. Cristofanilli noted that obesity was more frequent in women with IBC, 45 percent vs. 31 percent in non-IBC cases.

For the entire group, the median overall survival was 8.6 years and recurrence-free survival was 5.8 years. Both statistics were significantly worse for overweight and obese patients compared to those who were of normal weight or underweight.

Specifically regarding overall survival, for overweight LABC patients, five-year survival was 58.3 percent and 10-year survival was 44.1 percent; 58.6 percent of obese LABC patients lived five years and 42.4 percent lived 10 years. In contrast, 69.3 percent of women with LABC who were normal or underweight lived five years and 57.3 percent lived 10 years.

In women with IBC who were overweight, five-year survival was 45.3 percent and 10-year survival was 29.1 percent; 49.3 percent of obese IBC patients lived five years and 43.7 percent lived 10 years. In comparison, 55.1 percent of women with IBC who were normal or underweight lived five years and 50.9 percent lived 10 years.

For the design of the study, it's important to note that all patients received similar anthracycline-based treatments and that doses were not adjusted based on a patient's wei
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Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

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