Navigation Links
Body Mass Index gain throughout adulthood may increase risk of postmenopausal breast cancer
Date:4/20/2010

WASHINGTON, D.C. Reported mid-life increase in body mass index (BMI) may lead to substantially higher risk of postmenopausal breast cancer, according to results of a prospective cohort study presented at the American Association for Cancer Research 101st Annual Meeting 2010, held here April 17-21.

In previous studies, excess weight has been linked with increased risk of postmenopausal breast cancer. Scientists have speculated that in postmenopausal women, estrogen produced in adipose tissue, or body fat, may promote breast cell proliferation. Relatively few studies have looked specifically at increase in BMI and its timing in relation to postmenopausal breast cancer risk, which this study investigated.

The researchers analyzed information from 72,007 women in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial cohort, who were 55 to 74 years old at study entry. The analysis included 3,677 cases of postmenopausal breast cancer, which makes this one of the larger studies of its kind, according to the researchers.

The researchers observed the strongest associations among women who had never used menopausal hormone therapy; results were shown only for this group of women.

"Compared with women who maintained approximately the same BMI, those who had an increase of 5 kg/m2 or more between age 20 and study entry had a nearly twofold increased risk of breast cancer," said Laura Sue, M.P.H., a cancer research fellow at the National Cancer Institute (NCI).

Results showed that nearly 57 percent of the study population's BMI increased 5 kg/m2 or more between age 20 and study entry. A BMI increase of 5 kg/m2 is equivalent to a woman of average height, 5'4", gaining approximately 30 pounds.

Women who reported a BMI increase of 5 kg/m2 or more between age 20 and 50 were at an 88 percent increased risk of developing postmenopausal breast cancer, compared with women who reported a stable BMI. For women who reported a BMI increase of 5 kg/m2 or more between age 50 and study entry, risk increased 56 percent, compared with women who maintained BMI. BMI gain both before and after age 50 independently contribute to increased risk of postmenopausal breast cancer.


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Human development index linked to stem cell transplant rates and success in leukemia patients
2. LocumTenens.com Online Job Index Continues Rise in First Quarter 2010
3. New clinical prediction index to help patients considering kidney transplant
4. Tickerspy.com Announces New Stock Index Tracking Chinese Healthcare Stocks
5. Chindex International, Inc. Reports Third Quarter Fiscal Year 2010 Financial Results
6. MIB Life Index Reports North American Life Insurance Activity Up 3.9% in November
7. Study finds changes in fetal epigenetics throughout pregnancy
8. Educational Toy Franchise Expects Continued Growth Throughout Colorado in 2010
9. Toys"R"Us, Inc. Expands its Support of Autism Speaks Throughout North America
10. Study shows genital herpes virus reactivates widely throughout genital tract
11. Why symptoms of schizophrenia emerge in young adulthood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... Atlanta, GA (PRWEB) , ... February 21, 2017 ... ... firm, announced the acquisition of the predictive analytic firm Predixion’s Healthcare IT practice. ... of investment and is backed by giants including Accenture, GE Ventures, ...
(Date:2/21/2017)... Trenton, NJ (PRWEB) , ... February 21, 2017 , ... ... to a healthy lifestyle and make small changes that can lead to a lifetime ... for the possibility of a cardiac emergency. , The Athletic Trainers’ Society ...
(Date:2/20/2017)... ALEXANDRIA, VA (PRWEB) , ... February 20, 2017 , ... ... with Cambridge Healthcare to open and operate a state-of-the-art memory care community in Alexandria, ... of 2018 on a site just outside of Old Town. , The three-story ...
(Date:2/20/2017)... ... February 20, 2017 , ... The StayWell Company ... health care providers better manage patient health risks, foster behavior change and improve health ... in the world, will present a demonstration of its video capability at StayWell booth ...
(Date:2/20/2017)... ... February 20, 2017 , ... Houston dentist , ... dental care at his office, Antoine Dental Center. Emergency dentistry encompasses many treatments ... are at risk for serious complications and often experience severe pain. Not only ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... MELBOURNE, Australia , Feb. 21, 2017  IBM (NYSE: ... IBM Watson,s ability to detect abnormalities of the eye,s retina. ... trained a research version of Watson to recognize abnormalities in ... insights and speed in their early identification of patients who ... glaucoma, a leading cause of blindness in the developed world. ...
(Date:2/21/2017)... Medical Oxygen Concentrators Market: Overview ... Medical oxygen concentrators are used by patients ... having low level of oxygen in their blood ... are to be used only with prescription and ... concentrators work either on rechargeable lithium batteries or ...
(Date:2/21/2017)...   BeyondSpring Pharmaceuticals , a clinical stage ... immuno-oncology cancer therapies, today announced that the Company,s ... 2 trial of BeyondSpring,s innovative lead asset, ... lung cancer (NSCLC) with Docetaxel has been selected ... Immuno-Oncology Symposium in Orlando, Fla. ...
Breaking Medicine Technology: