Navigation Links
Body Mass Index gain throughout adulthood may increase risk of postmenopausal breast cancer
Date:4/20/2010

WASHINGTON, D.C. Reported mid-life increase in body mass index (BMI) may lead to substantially higher risk of postmenopausal breast cancer, according to results of a prospective cohort study presented at the American Association for Cancer Research 101st Annual Meeting 2010, held here April 17-21.

In previous studies, excess weight has been linked with increased risk of postmenopausal breast cancer. Scientists have speculated that in postmenopausal women, estrogen produced in adipose tissue, or body fat, may promote breast cell proliferation. Relatively few studies have looked specifically at increase in BMI and its timing in relation to postmenopausal breast cancer risk, which this study investigated.

The researchers analyzed information from 72,007 women in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial cohort, who were 55 to 74 years old at study entry. The analysis included 3,677 cases of postmenopausal breast cancer, which makes this one of the larger studies of its kind, according to the researchers.

The researchers observed the strongest associations among women who had never used menopausal hormone therapy; results were shown only for this group of women.

"Compared with women who maintained approximately the same BMI, those who had an increase of 5 kg/m2 or more between age 20 and study entry had a nearly twofold increased risk of breast cancer," said Laura Sue, M.P.H., a cancer research fellow at the National Cancer Institute (NCI).

Results showed that nearly 57 percent of the study population's BMI increased 5 kg/m2 or more between age 20 and study entry. A BMI increase of 5 kg/m2 is equivalent to a woman of average height, 5'4", gaining approximately 30 pounds.

Women who reported a BMI increase of 5 kg/m2 or more between age 20 and 50 were at an 88 percent increased risk of developing postmenopausal breast cancer, compared with women who reported a stable BMI. For women who reported a BMI increase of 5 kg/m2 or more between age 50 and study entry, risk increased 56 percent, compared with women who maintained BMI. BMI gain both before and after age 50 independently contribute to increased risk of postmenopausal breast cancer.


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Human development index linked to stem cell transplant rates and success in leukemia patients
2. LocumTenens.com Online Job Index Continues Rise in First Quarter 2010
3. New clinical prediction index to help patients considering kidney transplant
4. Tickerspy.com Announces New Stock Index Tracking Chinese Healthcare Stocks
5. Chindex International, Inc. Reports Third Quarter Fiscal Year 2010 Financial Results
6. MIB Life Index Reports North American Life Insurance Activity Up 3.9% in November
7. Study finds changes in fetal epigenetics throughout pregnancy
8. Educational Toy Franchise Expects Continued Growth Throughout Colorado in 2010
9. Toys"R"Us, Inc. Expands its Support of Autism Speaks Throughout North America
10. Study shows genital herpes virus reactivates widely throughout genital tract
11. Why symptoms of schizophrenia emerge in young adulthood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... To deal with these feelings, many turn to unhealthy avenues, such as drug or ... Center of Marne, Michigan, has released tools for healthy coping following a traumatic event. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
(Date:6/24/2016)... NY (PRWEB) , ... June 24, 2016 , ... ... Haute Living, is proud to recognize Dr. Barry M. Weintraub as a prominent ... “the most beautiful women in the world, and the most handsome men, look ...
(Date:6/24/2016)... Gaithersburg, MD (PRWEB) , ... June 24, 2016 ... ... and protocols for human induced pluripotent stem (iPS) cells and other difficult to ... PluriQ™ G9™ Cloning Medium. The PluriQ™ G9™ Gene Editing System is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Guerbet announced today that it has been named a ... One of 12 suppliers to receive the ... of Premier members through exceptional local customer service and ... lower costs. "We ... customer service from Premier," says Massimo Carrara , ...
(Date:6/23/2016)... NEW YORK , June 23, 2016 ... rough waters, but it continues to present great opportunities ... featured companies for today: Intrexon Corp. (NYSE: ... ), Arena Pharmaceuticals Inc. (NASDAQ: ARNA ), ... Learn more about these stocks and receive your complimentary ...
(Date:6/23/2016)... , June 23, 2016 ... "OTC Distribution in Europe 2016 Edition: The New Global Agenda ... OTC Distribution in Europe ... study that explores and tracks change. It identifies the driving ... environment for the consumer healthcare industry now and in the ...
Breaking Medicine Technology: