Navigation Links
Boceprevir: Indication of added benefit for specific patients
Date:12/9/2011

th boceprevir given in a triple combination with the former two drugs.

Reduction in secondary diseases: extent cannot be classified.

For the two indications of pretreated (treatment-experienced) and non-pretreated (treatment-naive) patients without cirrhosis, data from one approval study each (SPRINT-2 and RESPOND-2) were available. With the available studies, it is not possible to assess directly whether the new active ingredient influences secondary diseases, such as the development of liver cancer. This is partly because the studies have not lasted long enough for these patient-relevant outcomes to be recorded.

With respect to SVR, there was a clear advantage for boceprevir, both for pretreated patients and for non-pretreated patients without liver cirrhosis. However, SVR is not itself a patient-relevant outcome and cannot be equated with "cure", and there are no studies in which SVR is validated as a surrogate outcome in accordance with the usual criteria employed by IQWiG. Nevertheless, the Institute accepts SVR in the context of the assessment as a surrogate for the reduced incidence of liver cancer. This is because it is currently accepted that patients with no detectable hepatitis C virus in the blood are at lower risk of liver cancer. However, it is unclear how many cases of liver cancer can in fact be prevented by boceprevir.

For the outcome "secondary diseases", IQWiG recognizes an "indication" of a benefit for boceprevir. The requirements for a "proof" are not fulfilled, one reason being that the data are only derived from a single study each, with a comparatively small number of patients. Moreover, the scientific data do not permit a conclusive assessment of the number of patients in whom liver cancer is actually prevented. It is therefore unclear whether the added benefit is "minor", "considerable" or "major". For such a case, the corresponding legal ordinance specifies the assessment category of "unquanti
'/>"/>

Contact: Anna-Sabine Ernst
presse@iqwig.de
49-022-135-6850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Prasugrel: Indications of an additional benefit for some patients, but also of greater harm
2. Sanofi Pasteur announces FDA approval of menactra meningococcal conjugate vaccine indication for infants
3. Indications of Alzheimers disease may be evident decades before first signs of cognitive impairment
4. Early indications of Parkinsons disease revealed in dream sleep
5. Calorie count plus points based on added sugars, sodium, and saturated and trans fats recommended as new front-of-package nutrition labeling system
6. Ticagrelor: Considerable added benefit for specific patients
7. Hospitals encouraged to consider value-added service of hospital-based radiology groups
8. Pelvic Mesh for Incontinence May Carry Added Risk for Women: FDA
9. Phase 3 trial finds no benefit from atrasentan added to chemo for advanced prostate cancer
10. Newer Versions of the Pill Pose No Added Risk to Gallbladder
11. More Added Sugars, More Pounds?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... (PRWEB) December 20, 2014 The aftermath of ... quite a stir, not only in Hollywood, but worldwide. ... 18th , the ripples of that attack are starting a ... jobs at risk. But they are not the only ... could be in for some embarrassing times ahead, agents and ...
(Date:12/20/2014)... 20, 2014 The Twin Cities DI ... event in the nation! Over 250 financial professionals come ... information on the industry, get motivated to protect their ... people facing and overcoming the challenges of disability. , ... the nation came together to attend The 13th Annual ...
(Date:12/19/2014)... (PRWEB) December 20, 2014 It’s very easy ... is something that is put to the wayside until Christmas ... still have that travel “itch” and that burning desire to ... accommodates families on their journey to Telluride with a no-fuss, ... visitors to and from the resort, and ensure that all ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 ... dedicated to developing educational events, tools and resources ... Rouxbe Cooking School , the world’s leading online ... prescription every human being needs: Culinary Rx. As ... cooking course, Culinary Rx, scheduled for debut spring ...
(Date:12/19/2014)... These vanadium reserves are mostly found in ... tons of vanadium were produced globally in 2013, up ... at 6.7% AAGR during the period from 2001 to ... the largest consumer, accounted for more than 90% of ... and the chemical industry. , View Full Report at ...
Breaking Medicine News(10 mins):Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 3Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 4Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 5Health News:The 13th Annual Twin Cities DI Day Now On Video 2Health News:The 13th Annual Twin Cities DI Day Now On Video 3Health News:Days Inn Montrose Colorado Delivers Last Minute Holiday Season Ski Getaway Accommodations 2Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 2Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 3Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 4Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 2Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 3
... RIO DE JANEIRO , Jan. ... < GO >; Reuters: AMIL3 SA), the largest managed,care organization ... and,Exchange Commission) Instruction 358/02, informs that was approved in Board,Meeting ... restricted selling efforts (according to CVM Instruction 476/09), with,the objective ...
... group target use of cell phones and texting devices, ... 500,000 people were injured and nearly 6,000 people were ... who was distracted while using a cell phone or ... , To cut down on the growing number of ...
... , , WEST PALM BEACH, Fla. , ... Conference Korea ( http://www.asiamedicaltourismcongress.com ) will take place April, 13-16th, ... the Medical Tourism Association (MTA) and Korea Health Industry Development ... destinations for medical tourism and global healthcare in the world. ...
... Experimental med looks promising, researchers say , TUESDAY, ... may help prevent esophageal cancer, a new study shows. ... treatment of Alzheimer,s disease, is known to have side ... cells that line the colon are similar to those ...
... as 50 per cent of people bring their work home ... University of Toronto that describes the stress associated with work-life ... the extent to which work was interfering with personal time ... Sociology professor Scott Schieman (UofT) and his coauthors Melissa Milkie ...
... their meds, researchers say , TUESDAY, Jan. 12 (HealthDay ... to long-term treatment with cholesterol-lowering statins could prevent twice ... researchers say. , It,s estimated that only about half ... still taking them five years later, according to background ...
Cached Medicine News:Health News:FocusDriven Seeks to Crack Down on Distracted Drivers 2Health News:Global Healthcare & Medical Tourism Conference Korea Announced for April 13-16th, 2010 2Health News:Global Healthcare & Medical Tourism Conference Korea Announced for April 13-16th, 2010 3Health News:When work interferes with life 2Health News:Long-Term Statin Use Best Way to Cut Cardiovascular Deaths 2
(Date:12/19/2014)... DUBLIN , Dec. 18, 2014 Research ... announced the addition of the "Micro Market ... report to their offering. ... dermatological treatment is progressing steadily, which has resulted ... diagnostic devices market. The main purpose of these ...
(Date:12/19/2014)...  RESMED INC. (NYSE: RMD ) today announced ... 2015 results on Thursday, January 22, 2015, after the New ... results will be issued after 1:00 p.m. US Pacific Time ... results and future outlook. The earnings call is ... the live webcast of the call can be accessed on ...
(Date:12/19/2014)... LYON, France , Dec. 19, 2014 /PRNewswire/ ... and Adocia (Euronext Paris: FR0011184241 – ADOC) today announced ... insulin, known as BioChaperone Lispro, for treatment in people ... relies on Adocia,s proprietary BioChaperone® technology and is currently ... will develop BioChaperone Lispro with the goal of optimizing ...
Breaking Medicine Technology:Micro Market Monitor: North American Dermatology Diagnostic Devices Market 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 3ResMed To Announce Second Quarter 2015 Results 2Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 2Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 3
... Ore., May 13 Dried blood spots are ... and transport,for blood tests. In an article published ... and Technology (2008; 2(2):242-3), Ramakrishnan Lakshmy,PhD, explains that ... "powerful tool", for,mass disease screening programs, especially in ...
... Clinical Study Initiated Following Success with 8 Patients, ... (OTC,Bulletin Board: DSCI), a provider of advanced wound ... and thoracic surgeons from the,University of Wurzburg, Germany, ... with deep sternal wound infections (DSWI), a,condition that ...
Cached Medicine Technology:Blood Spot Technology at ZRT Highlighted in March Issue of Journal of Diabetes Science & Technology - A Convenient Alternative to Serum Testing for Health Screening 2Cardiovascular Researchers Use MEDIHONEY(TM) on Sternal Infections Following Open-Heart Procedures 2Cardiovascular Researchers Use MEDIHONEY(TM) on Sternal Infections Following Open-Heart Procedures 3
Inoculum Broth with Calcium Chloride and Phytone....
12% Tryptone, 24% Yeast Extract, 4.0% Glycerol. Supplied with 1 liter of 10x phosphate buffer (0190-1L)....
10% Casein digest (NZ amine), 5.0% Sodium Chloride, 5.0% Yeast Extract....
0.5% Yeast Extract, 2.0% Tryp, 10mM Sodium Chloride, 2.5mM Potassium Chloride, 10mM Magnesium Chloride, 10mM Mag. Sulfate....
Medicine Products: