Navigation Links
Blue Dye Halts Worsening Paralysis in Animal Study
Date:7/28/2009

Discovery could lead to new treatments for people with spine injuries

TUESDAY, July 28 (HealthDay News) -- The food additive that makes M&Ms and Gatorade blue may help prevent the secondary damage that occurs after a spinal cord injury, a new study suggests.

Researchers say that the dye, called Brilliant Blue G (BBG), stops the cascade of molecular events that can expand the area of injury and permanently worsen paralysis.

This finding builds on landmark research that detailed how ATP, the vital energy source that keeps the body's cells alive, pours into the area around a spinal cord injury, killing off healthy and uninjured cells. This previous research also laid out a potential way to stop secondary spinal injury: use oxidized ATP to block the ATP, according to background information provided in a news release from the University of Rochester.

Rats with damaged spinal cords that were injected with oxidized ATP recovered much of their limb function and were able to effectively, if not gracefully, walk again, the earlier research found.

The new study has found a compound that does the same thing, and it doesn't have to be injected directly into the injured spinal cord to work, the study authors explain in their report, published online in this week's issue of the Proceedings of the National Academy of Sciences.

"While we achieved great results when oxidized ATP was injected directly into the spinal cord, this method would not be practical for use with spinal cord-injured patients," said lead researcher Dr. Maiken Nedergaard, a professor of neurosurgery and director of the Center for Translational Neuromedicine at the University of Rochester Medical Center.

"First, no one wants to put a needle into a spinal cord that has just been severely injured, so we knew we needed to find another way to quickly deliver an agent that would stop ATP from killing healthy motor neurons. Second, the compound we initially used, oxidized ATP, cannot be injected into the bloodstream because of its dangerous side effects," Nedergaard explained in the news release.

In the search for a compound that would thwart ATP attacks and could be administered intravenously, Nedergaard stumbled upon BBG.

An intravenous injection of BBG significantly reduced secondary injury in spinal cord-injured rats, which improved to the point of being able to walk again, although with a limp. There was a side effect, however. Injected rats had a blue tinge to their skin for a while.

While more study is needed, Nedergaard and longtime collaborator Dr. Steven Goldman, chair of the University of Rochester Department of Neurology, hope that BBG and related agents will yield new treatments for acute spinal cord injuries.

More information

The U.S. National Institutes of Health offers information on spinal cord injuries.



--Dennis Thompson



SOURCE: University of Rochester, news release, July 27, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Photo: New Data Show Gleevec(R) Halts Progression to Advanced Stages of Life-Threatening Form of Leukemia in Sixth Year of Treatment
2. Scripps research scientists find new genetic mutation that halts the development of lupus
3. Experimental Vaccine Halts Prostate Cancer in Mice
4. Manufacturer Halts Production of Blood Thinner Heparin
5. St. Jude finds signaling system that halts the growth of a childhood brain cancer
6. Surgical technique halts cell loss, Parkinsons researchers find
7. PA Department of Health Halts Admissions at Commonwealth Medical Center in Beaver County
8. Gastric Bypass Halts Diabetes in Obese Teens
9. Kellogg Halts Sales of Peanut Butter Crackers
10. FDA Halts New Applications From Indian Drug Makers Plant
11. Interferon does not slow or stop hepatitis C from worsening, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blue Dye Halts Worsening Paralysis in Animal Study
(Date:2/8/2016)... ... February 08, 2016 , ... Steve Helwig & Associates ... vital new community enrichment program, has teamed up with Citizens Opposed to Domestic Abuse ... from intimate abuse. To support all those victimized by the fear of violence in ...
(Date:2/8/2016)... , ... February 08, 2016 , ... Delta Dental of ... help combat pancreatic cancer. , Gary D. Radine, who recently retired as president and ... American Cancer Society’s 2015 CEO of the Year , helped lead the effort ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... While a significant number of women and men with eating disorders report a ... that best predicts the development of an eating disorder. , At the ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... than 50% lower incidence rate of type 2 diabetes in the GrassrootsHealth cohort ... is time to make a change in public health,” states Carole Baggerly, Director ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... speaking on how healthcare companies can use newly released government data on populations ... a population and intervene and capture the value they create to succeed in ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... EAST NORRITON, Pa. , Feb. 8, 2016 ... acquisition of November Research Group (NRG),s pharmacovigilance ... of pharmacovigilance system-related consulting services and an Oracle ... regulatory compliance services to Life Sciences companies. ... acquisition strengthens and expands HighPoint,s life sciences capabilities ...
(Date:2/8/2016)... Pa. , Feb. 8, 2016  As part of ... has announced today the appointment of Lori Chmura ... than 20 years in the industry, Chmura,s extensive experience in ... the advancement of Dune Medical Devices. ... will be responsible for leading all sales, marketing and operational ...
(Date:2/8/2016)... Velano Vascular, a medical technology company transforming ... their practitioners, announced today that the company has raised ... the proceeds from this financing, an extension of a ... to support the development and commercialization of the company,s ... Philadelphia , and a number ...
Breaking Medicine Technology: