Navigation Links
Bloodstream scavenger inhibits clotting without increased bleeding
Date:7/23/2012

DURHAM, N.C. A compound that mops up debris of damaged cells from the bloodstream may be the first in a new class of drugs designed to address one of medicine's most difficult challenges -- stopping the formation of blood clots without triggering equally threatening bleeding.

In a mouse study published online July 23, 2012, in the journal Proceedings of the National Academy of Sciences, Duke University Medical Center scientists report that the experimental compound called PAMAM G-3 actually prevents activation of the process that leads to the formation of dangerous blood clots, while avoiding any impact on the factors that are essential to normal blood clot formation.

"In the thrombosis (clotting) space, the holy grail has been to make something anti-thrombotic that doesn't significantly increase your chance of hemorrhage or bleeding," said Bruce A. Sullenger, Ph.D., director of the Duke Translational Research Institute and senior author of the study. "We think this is a promising example of a type of compound that could do that. If it can be clinically developed and exhibit the same properties in humans, clearly that would improve safety and outcome of treating patients who have thrombotic disease."

Thrombosis, the formation of blood clots in the circulatory system that form blockages, is a major cause of death in the Western world, contributing to the mortality associated with leading killers such as myocardial infarctions, stroke, and even cancer.

"If you can control thrombosis without greatly increasing hemorrhage or bleeding risk, you would address a major unmet medical need," Sullenger said. "It would have potentially major clinical implications."

The thrombosis study builds upon previous work by Sullenger and his group, which showed that the compounds called nucleic acid-binding polymers or NABPs, which include PAMAM G-3, have potent anti-inflammatory properties. Work published last year by Sullenger's
'/>"/>

Contact: Sarah Avery
sarah.avery@duke.edu
919-668-1306
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cancer Cells in Bloodstream Show Great Diversity: Study
2. Cervical Cancer Spotted Later in Women Without Health Insurance
3. Cancer screening rates comparable for those with and without rheumatoid arthritis
4. Device converting images into music helps individuals without vision reach for objects in space
5. Trivedi Beef, LLC Announces Breakthrough Beef Industry Data without the use of Antibiotic Drugs, Hormones or Steroids
6. Obese Teens Can Have Heart Damage Without Showing Signs
7. Breathing during radiotherapy - how to hit the treatment target without causing collateral damage
8. Screening for breast cancer without X-rays: Lasers and sound merge in promising diagnostic technique
9. Power without the cord
10. Increased cardiovascular risk in HIV-infected patients may relate to arterial inflammation
11. HIV-infected women do not appear to be at increased risk of cervical cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... (PRWEB) , ... August 01, 2015 , ... Have you ever wondered what “Karma” really ... you hear the word “Karma.” , Vedic tradition, which gave birth to Hinduism, is ... one of the central concepts of this tradition. According to the wisdom of this heritage, ...
(Date:8/1/2015)... ... August 01, 2015 , ... Brig and Lita Hart, ... announcing the unification of their Healthy Home mission with the HOPE Movement of EvolvHealth. ... the founders of both companies have agreed to join their missions of purpose together ...
(Date:8/1/2015)... ... , ... BeverlyD, owner and founder of BeverlyD Luxe Organic Hair Care, has ... business donation to kick off the campaign for healing and Well-Being. , BeverlyD has ... complete line of raw, organic hair care products, as well as her book, Hair ...
(Date:7/31/2015)... ... July 31, 2015 , ... Ticket Down is a reputable source of authentic ... Grand Garden Arena. Fans of every genre of music will have an act they ... first day of the festival, the following artists will perform: Sam Smith, Coldplay, Kenny ...
(Date:7/31/2015)... ... July 31, 2015 , ... Ticket Down is a reliable source for ... Chicago at Grant Park. The festival will end on Sunday, August 2nd. ... for the annual Lollapalooza. This unique and unbelievably popular festival attracts the best ...
Breaking Medicine News(10 mins):Health News:Nithyananda Yoga Foundation to Conduct Global Webinar on Karma at No Charge on August 1st 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:March4thforWellBeing Foundation Kickoff 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 3Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2
... severe chronic obstructive pulmonary disease (COPD), combining a ... number of exacerbations by 35 percent.// ,Peter ... Maingau Hospital in Frankfurt am Main, Germany, and ... COPD from 92 respiratory centers across Germany. All ...
... ,Scientists have always sought to find the pill that ... thirds of the population can be described as obese. , ... of 2.2 million pounds before Professor Steve Bloom and ... create a chewing gum or nasal spray to allay ...
... problems among people who have spent years recovering from serious ... depression, //with women being most vulnerable. ,While the ... a valuable tool that could spur burn centers to devote ... to looking at whether we can fix this or alter ...
... pubic bone as a source of bone for grafting may ... or 'hip bone,' according to a report in the November/December ... study, the pubic bone could become the new standard for ... Dr. John W. Polley and colleagues of Rush University Medical ...
... rhythms reflect their emotional state and can respond to ... a pilot study conducted by Alliant International University Professor ... in contact, a horse’s heart rate may mirror a ... between man and beast. The horse as emotion detector ...
... beats per minute (BPM). If the rhythm of the heart goes ... This was the case for Jeffrey Nauser. //His irregular heartbeat was ... life hung in the balance each time. ,Jeffrey’s story ... sweating profusely, got lightheaded and weak in the knees. He assumed ...
Cached Medicine News:Health News:Chew That Fat Away 2Health News:Burn Patients Need More Help Coping With Depression 2Health News:New Technique Uses Pubic Bone for Grafting 2Health News:Horse Heart Coherence May Be Key To Non-invasive Stress Detection 2Health News:Rewiring the Heart 2
(Date:7/31/2015)... and SAN DIEGO , July 31, ... company Eisai Co., Ltd. (Headquarters: Tokyo ... and Halozyme Therapeutics, Inc. (Headquarters: San Diego, ... Torley , "NASDAQ: HALO") have signed a clinical collaboration ... ® , "eribulin") in combination with Halozyme,s investigational drug ...
(Date:7/31/2015)... HYDERABAD, India , July 31, 2015 /PRNewswire/ ... Billing and CRM solutions for video, data and cloud ... (PoC) with a leading pharma giant for Internet ... managing different IoT applications offered on subscription model. ... Pharma giant is striving for business ...
(Date:7/30/2015)... 2015  ResMed (NYSE: RMD ) ... agreement to acquire Curative Medical, a privately-held ... breathing medical devices and accessories. ... leadership in sleep and respiratory medicine, will ... suffering from sleep-disordered breathing and ...
Breaking Medicine Technology:Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 2Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 3Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 5Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 6Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 2ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 3
... Oct. 31, 2011 GP Strategies Corporation ... performance improvement solutions provider of sales and ... through its principal operating subsidiary General Physics Corporation, will ... 3, 2011. (Logo:  http://photos.prnewswire.com/prnh/20110404/MM77341LOGO-a ...
... Oct. 31, 2011 Everist Genomics, a rapidly ... diagnostics and prognostics, announced today that it has ... of Angiologix, Inc., the developer of the AngioDefender™ ... dysfunction is a key biomarker of early-stage atherosclerosis ...
Cached Medicine Technology:GP Strategies Corporation to Report Third Quarter 2011 Results on November 3, 2011 2Everist Genomics Announces Acquisition of Angiologix, Inc. 2Everist Genomics Announces Acquisition of Angiologix, Inc. 3Everist Genomics Announces Acquisition of Angiologix, Inc. 4Everist Genomics Announces Acquisition of Angiologix, Inc. 5
The torso blanket is designed to affix to the lower abdominal area and cover the upper half of the body....
The fabric is antistatic and non-linting and is both oil and water repellent.These superior blankets are an environmental friendly alternative to disposable blankets....
The upper body blanket covers the upper torso, arms, neck, and head of the patient....
... system delivers cold air to the patient ... temperatures down to 10C. Cooling the body ... been used as a therapeutic tool, particularly ... hypothermia is now widely used as a ...
Medicine Products: