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Blood vessels might predict prostate cancer behavior
Date:11/3/2009

death in American men.

This study analyzed tumor samples and clinical outcome data from men participating in the Health Professionals Follow-Up Study, which involves 51,529 male North American dentists, optometrists, podiatrists, pharmacists and veterinarians.

After an average follow-up of 10 years, 44 of the 572 men had developed metastatic cancer or died of their cancer.

Men whose tumors had smaller vessel diameters were six times more likely to have aggressive tumors and die of their disease, and those with the most irregularly shaped vessels were 17 times more likely to develop lethal prostate cancer.

The findings were independent of Gleason score, a widely used predictor of prognosis based on a prostate tumor's microscopic appearance, and of prostate specific antigen (PSA) level, a blood test used to identify the presence of prostate cancer.

These findings currently apply to men with local disease, whose PSA is only modestly elevated, and who are younger and more likely to choose surgery.

"If our findings are validated by larger studies, particularly in biopsy specimens, the measurement of tumor blood vessel architecture might help determine the choice of therapy, with the goal of improving long-term survival."


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Contact: Doug Flowers
Doug.Flowers@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

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