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Blood vessel disease of retina may be marker of cognitive decline
Date:3/15/2012

Women 65 or older who have even mild retinopathy, a disease of blood vessels in the retina, are more likely to have cognitive decline and related vascular changes in the brain, according to a multi-institutional study led by scientists at the University of California, San Francisco (UCSF).

The findings suggest that a relatively simple eye screening could serve as a marker for cognitive changes related to vascular disease, allowing for early diagnosis and treatment, potentially reducing the progression of cognitive impairment to dementia.

As retinopathy usually is caused by Type II diabetes or hypertension, a diagnosis could indicate early stages of these diseases, before they are clinically detectable. Early diagnosis could allow for lifestyle or drug interventions when they might be most effective.

"Lots of people who are pre-diabetic or pre-hypertensive develop retinopathy," said the lead author of the study, Mary Haan, DrPH, MPH, UCSF professor of epidemiology and biostatistics. "Early intervention might reduce the progression to full onset diabetes or hypertension."

The results, reported in the March 14, 2012, online issue of Neurology, were based on data from the Women's Health Initiative Memory Study and the Site Examination study, two ancillary studies of the Women's Health Initiative Clinical Trial of Hormone Therapy.

In the study, the team followed 511 women with an average starting age of 69, for 10 years. Each year, the women took a cognition test focused on short-term memory and thinking processes. In the fourth year, they received an exam to assess eye health. In the eighth year, they received a brain scan.

Of the full group of women, 39 women, or 7.6 percent, were diagnosed with retinopathy. On average, these women scored worse on the cognition test than the other women. They had more difficulty, for instance, recalling a list of several words five minutes after hearing them.

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Contact: Jennifer O'Brien
jennifer.obrien@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

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