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Blood vessel bends and branches put the brakes on statins
Date:7/9/2009

forward to discover how best to restore disease-protection and drug-responsiveness in vulnerable parts of the circulation. Imperial College London is well placed to undertake such research having recently become a BHF Centre of Research Excellence - a scheme through which we support innovative multidisciplinary approaches to the fight against heart disease."

The research is published today in the Journal of Biological Chemistry.

For more information please call the BHF press office on 020 7554 0164 or 07764 290 381 (out of office hours) or email newsdesk (at) bhf.org.uk

Notes to editors
(1) Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothelium exposed to laminar shear stress and impaired by disturbed flow.
Ali F, Zakkar M, Karu K, Lidington EA, Hamdulay SS, Boyle JJ, Zloh M, Bauer A, Haskard DO, Evans PC, Mason JC. J. Biol. Chem., Jul 2009; 284: 18882-18892; doi:10.1074/jbc.M109.009886

(2) NHS Information Centre. Prescription Cost Analysis 2008 http://www.ic.nhs.uk/webfiles/publications/PCA%
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