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Blood transfusions and outcomes
Date:4/22/2009

n that transfusion itself may be a risk factor for adverse patient outcomes. It has been known for some time that blood undergoes many physical and chemical changes during storage, losing its ability to supply oxygen to vital organs and triggering inflammatory and immune reactions when transfused. It is now thought by some that these storage-related problems may result in negative outcomes to patients.

ICCTO was convened by two professional medical societies, the USA based Society for the Advancement of Blood Management (SABM) and the international Medical Society for Blood Management (MSBM), out of concern for the lack of evidence supporting transfusion effectiveness and the growing number of studies reporting the association between transfusion and negative patient outcomes. Because blood transfusion came into medical use decades ago, it has never been subject to the same rigorous safety and efficacy assessment process applied today to other drugs and treatments before they are approved for use. This has resulted in a great deal of uncertainty and lack of knowledge among physicians as to whether a patient should or should not be transfused. As a consequence, there is enormous variation in transfusion practice between countries, states within countries, hospitals and even between clinicians within the same institution.

The accepted "consensus conference" process using the RAND-UCLA method was chosen to unravel some of this uncertainty. This method involves a comprehensive review of all published scientific studies on a treatment, after which a panel of experts assesses a series of patient scenarios using the scientific literature to determine whether the treatment has evidence to support that it will improve the patient's outcome.

The ICCTO panelists also considered what has come to be known as the Bradford Hill Criteria for establishing causation, the process Sir Austin Bradford Hill and Sir Richard Doll used in the 1960s to establish
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Contact: Dave Schemelia
dschemelia@healthstarpr.com
646-722-8819
HealthStar PR
Source:Eurekalert

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