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Blood-thinning treatment standards changing for heart patients, new research shows
Date:12/9/2010

The risk of ischemic stroke in non-valvular atrial fibrillation appears to have declined, perhaps as a result of more aggressive control of blood pressure and lipid levels. Our analysis, using a more contemporary group of patients with atrial fibrillation from the ATRIA study, suggests that the threshold has shifted such that the balance of risk and benefit of anticoagulation tips in favor of warfarin at a higher CHADS2 score than in the past."

However, he says that as safer anticoagulants become available, the tipping point will shift again.

"With the advent of new anticoagulants and antithrombotic therapies, along with non-pharmacological interventions for atrial fibrillation, and the improbability of clinical trials performing head-to-head comparisons of these treatments, a decision-analytical framework may be one of the few ways to compare new treatments as they become available," he says."These data have implications for future guidelines as well as real-world bedside decision-making."


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Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center
Source:Eurekalert

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