Navigation Links
Blood test may identify lung cancer patients likely to respond to erlotinib
Date:4/30/2010

Testing for the presence of specific cancer protein 'fingerprints' in the blood of lung cancer patients may be a useful means of identifying a subgroup whose tumors are more likely to shrink when treated with the drug erlotinib, especially when other testing methods are unavailable, according to new data presented at the 2nd European Lung Cancer Conference in Geneva, Switzerland.

Erlotinib is one of a class of drugs that specifically inhibits an important cell-surface molecule known as the epidermal growth factor receptor (EGFR), which is highly expressed in some forms of cancer, including lung cancer. By blocking this receptor, drugs such as erlotinib aim to slow tumor growth and proliferation.

Prof David Carbone from Vanderbilt-Ingram Cancer Center in Nashville, Tennessee, and Canadian colleagues analyzed blood samples from the NCIC Clinical Trials Group (NCIC CTG) BR.21 study that had shown that erlotinib improved survival compared to placebo in patients with advanced non-small-cell lung cancer who had already tried one or two other drugs.

In the new study, the researchers analyzed blood samples that had been taken from some patients before they started treatment in the BR.21 study. They performed this analysis on patients who received the drug and on patients who received the placebo, looking for specific proteomic profiles already known to predict outcomes in patients treated with EGFR-blockers.

"The bottom line is that the proteomic test --comparing 'good' and 'poor' profiles-- was strongly prognostic in both erlotinib and placebo arms," said Prof Carbone. "Proteomics 'good' patients also had a significantly higher response rate than proteomics 'poor' patients (9.8% vs. 0.9%, p=0.002).

Prof Carbone notes that there are other methods available to analyze the EGFR pathway of lung cancers, including sequencing of the EGFR gene, or a technique known as fluorescence in-situ hybridization (FISH) to assess EGFR gen
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Blood stem-cell transplant regimen reverses sickle cell disease in adults
2. Blood Thinner Combos Risky for Heart Attack Patients
3. China Cord Blood Corporation Announces Results for the Quarter and Six Months Ended September 30, 2009
4. A better sign of blood vessel narrowing and early coronary artery disease
5. American Red Cross and Other U.S. Blood Centers Send Blood to Haiti
6. Analysis Examines Ultrasound Use for Blood Clots
7. Minnesota Vikings Team With Memorial Blood Centers Again for Annual Blood Drive
8. Newly discovered mechanism by which blood clots form
9. Long Before Symptoms, Blood May Reveal Rheumatoid Arthritis
10. Fat Tissue May Be a Source of Valuable Blood Stem Cells, Study Says
11. Hematologists Can Now Earn CME Credits Through the Journal Blood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... To kick off the fall season ... One Spas retailers across the country are offering 0% ... The Hot Tub Tailgate Event is from August 29th-September ... more information and to apply early! , As the ... wide variety of outdoor hot tubs with exclusive features ...
(Date:8/28/2014)... 28, 2014) A fortuitous collaboration at Rice ... a recently discovered natural antibiotic. , The laboratory ... someday help bolster the fight against bacteria that ... around the world. , As part of ... structural biologist Yousif Shamoo and their colleagues created ...
(Date:8/28/2014)... researchers place glue directly on the nerve stumps, but ... and allows glue to easily invade the nerve ends. ... to insert the nerve ends into the conduit because ... Xiangdang Liang and co-workers from the General Hospital of ... technique and defined the best parameters for its use ...
(Date:8/28/2014)... be treated with nasal septum cells. Researchers at the ... cells taken from the nasal septum are able to ... can thus repair articular cartilage defects. The nasal cartilage ... environment is associated with the expression of so-called HOX ... has published the research results together with the report ...
(Date:8/28/2014)... OTTAWA, August 28, 2014 One in every 200 ... with the number of people living with the disease ... according to a study by researchers at the Institute ... Eastern Ontario (CHEO), and the Ottawa Hospital Research Institute. ... prevalence in the world. , The study, published this ...
Breaking Medicine News(10 mins):Health News:Synthesis produces new antibiotic 2Health News:Synthesis produces new antibiotic 3Health News:Synthesis produces new antibiotic 4Health News:From nose to knee: Engineered cartilage regenerates joints 2Health News:Ontario has one of the highest rates of IBD in the world 2
... caries can destroy most of a child,s teeth by ... Indians and Alaskan natives. Although the link between ... has been known for almost a century, progress in ... the disease has remained elusive. The ...
... The American College of Physicians (ACP) today told the ... including enacting a permanent end to scheduled Medicare sustainable ... for Congress to act was demonstrated by today,s release ... across-the-board cut in Medicare payments to doctors on January ...
... , THURSDAY, Nov. 3 (HealthDay News) -- Allergy ... costs and can now provide relief to allergy sufferers ... And while allergy shots are currently given under the ... investigated, delegates heard at this week,s annual scientific meeting ...
... the first time, researchers have combined gene therapy ... severe, crippling bleeding disorder hemophilia A in large ... new therapies for human patients. Researchers at ... Medicine, collaborating with other institutions, report in ...
... HealthDay Reporter , WEDNESDAY, Nov. 2 (HealthDay News) -- ... subset of hard-to-treat hemophilia patients also seems to be effective ... this study, published in the Nov. 3 edition of the ... one and didn,t last long, the results do raise the ...
... Men with locally advanced or high-risk prostate cancer who ... are less likely to die from their disease, shows ... Margaret Hospital (PMH) Cancer Program, University Health Network. ... Lancet (doi: 10.1016/S0140-6736(11)61095-7). Principal investigator Padraig Warde, ...
Cached Medicine News:Health News:NYUCD awarded $2.2 million NIH grant to decode genome of caries-causing bacteria 2Health News:NYUCD awarded $2.2 million NIH grant to decode genome of caries-causing bacteria 3Health News:Congress must 'go big' on physician payment reform 2Health News:Congress must 'go big' on physician payment reform 3Health News:Improved Allergy Shots Might Be on Horizon 2Health News:Gene therapy shows promise as hemophilia treatment in animal studies 2Health News:Using Drug for Prevention Might Help in Hard-to-Treat Hemophilia 2Health News:Using Drug for Prevention Might Help in Hard-to-Treat Hemophilia 3Health News:Radiation plus hormone therapy greatly improves survival 2
(Date:8/28/2014)... , Aug. 28, 2014 Nonin Medical, Inc., ... in noninvasive medical monitoring, today announced that the Food ... 3231 OEM/eHealth finger pulse oximeter for use in ... oximeter plugs into a telemedicine hub or kiosk through ... rate in pediatric to adult patients. The Model 3231 ...
(Date:8/28/2014)... R.I. , Aug. 28, 2014  In recognition ... developing health complications from the flu, pneumonia, shingles ... ® have declared September to be Senior ... they age, it is important that adults ages ... on their vaccinations. CVS pharmacists and MinuteClinic nurse ...
(Date:8/28/2014)... Pa. , Aug. 28, 2014  Robotic ... patients, and media, both for the promise of ... safety. The quick deployment of surgical robots and ... are prompting facilities to evaluate their robotic surgery ... entire surgical team.    ECRI Institute ...
Breaking Medicine Technology:Nonin Medical Announces FDA Clearance of Nonin Model 3231 USB Pulse Oximeter 2September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 2September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 3September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 4Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 2Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 3Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 4Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 5
... 25, 2007 - Reata,Pharmaceuticals, Inc. today announced ... company's Synthetic Triterpenoid programs in,the May 2007 ... The article, "Triterpenoids and rexinoids as multifunctional,agents ... by researchers,and Reata scientific collaborators from the ...
... - Introgen,Therapeutics, Inc. (NASDAQ:INGN) today announced the publication ... survival,pathway impacts the anticancer activity of INGN 241. ... tumor killing effects of,INGN 241 in cell culture ... Introgen and The University of Texas M. D. ...
Cached Medicine Technology:Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer 2Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer 3Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer 4Preclinical Studies Identify Novel Approach for Enhancing the,Anticancer Activity of Introgen's INGN 241 2Preclinical Studies Identify Novel Approach for Enhancing the,Anticancer Activity of Introgen's INGN 241 3
... Unique product designed for LASIK surgery ... to irrigate the corneal interface and/or stromal ... the flap and helps elevate the flap ... 7/8in (.40 x 22mm) Formed 9mm from ...
... designed for LASIK surgery and other types ... corneal interface and/or stromal bed. Flattened tip ... helps elevate the flap edge. Multiple ports ... x 22mm) Formed 9mm from end. Two ...
... designed for LASIK surgery and other ... irrigate the corneal interface and/or stromal ... under the flap and helps elevate ... multi-directional irrigation. 25G x 7/8in (.50 ...
... Cannula tip is specially ... insertion through wound and manipulation ... x 3.5mm, flexible tubing 25cm, ... 2mm. Unique annular rings ...
Medicine Products: