Navigation Links
Blood test for lung cancer may be possible
Date:5/19/2008

ATS 2008, TORONTOA simple blood test may be able to detect lung cancer in its earliest stages with unprecedented accuracy, according to new research to be presented at American Thoracic Societys 2008 International Conference in Toronto on Tuesday, May 20.

The possibility of developing a non-invasive test to distinguish cancerous from benign lesions in the lungs has enormous implications, not just for the world of medicine, but for every individual patient who has gone through the harrowing experience of having to wait for conclusive biopsy results after preliminary testing.

CT screening results in the detection of lung nodules in 20 to 60 percent of subjects, said Anil Vachani, M.D., assistant professor of medicine at the University of Pennsylvania. This high false-positive rate requires patients to undergo extensive follow-up investigations, such as serial CT scans, PET scans or biopsies. This test may be able to obviate the need for such things if it is developed into a large scale diagnostic tool.

Because lung cancer is a very diverse disease, screening for it can be very difficult. The researchers hoped to identify a stable and consistent way of determining the presence of lung cancer by testing for the gene expression of white blood cells.

Rather than screening for factors released by the incipient tumor into the blood stream, the test Dr. Vachani and colleagues used looked at gene expression in the subjects own circulating white blood cells. We found that the types of genes present in these cells could tell us whether or not cancer was present, explained Dr. Vachani.

To test the accuracy and validity of the method, the researchers recruited 44 patients with early stage lung cancer and 52 control subjects who were matched for age, smoking status, gender and race. They then used a number of genetic arrays to determine the best targets for detecting the presence of cancer. They found that a 15 gene array had the highest accuracy, at 87 percent.

These findings suggest that lung cancers interact with circulating white blood cells and change the types of genes that are active in these cells. This finding can be potentially used to develop a non-invasive diagnostic test for patients suspected of having lung cancer, said Dr. Vachani. A diagnostic test that could more accurately determine the risk of cancer in patients would be extremely valuable and have very important economic implications by reducing unnecessary surgery, biopsies and repeated imaging tests.

We are planning to perform validation studies to further evaluate the utility of this approach for diagnosing lung cancer in a larger population, concluded Dr Vachani. If our results are encouraging, we would like to test this in a prospective clinical trial.


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Specific antagonism lowers blood pressure
2. Restricting Blood Flow May Help Heart Bypass Patients
3. FDA Updates Prescription Guidelines for Blood Thinner
4. Doctors Often Miss High Blood Pressure in Kids
5. Back to School Means Return of School Blood Drives
6. Blood-flow detector software show promise in preventing brain damage
7. FDA Approves New Roche West Nile Virus Blood Screening Test
8. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
9. Laser blasts viruses in blood
10. Study Demonstrates Marteks Algal DHA Oil Improves Blood Triglyceride Lipid Levels
11. LifeMasters Provides Tips for Maintaining a Healthy Blood Cholesterol Level
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... August 18, 2017 , ... More than 20,000 pairs of shoes made their ... to an ambitious venture that conjoined the passions of an NBA star, a Liberty ... Liberty community. These shoes will save lives from the rampant infections transmitted through the ...
(Date:8/18/2017)... York, NY (PRWEB) , ... August 18, 2017 ... ... launch of this summer’s edition of “Vision & Hearing,” advocating for active, healthy ... campaign focuses on resources available for individuals with hearing impairments and shares the ...
(Date:8/18/2017)... ... August 18, 2017 , ... Hernandez ... consultations to communities throughout the greater DC region, is inaugurating a “New Leash ... rescuing local animals and training them to be companions for veterans in need. ...
(Date:8/18/2017)... ... 18, 2017 , ... The Brian Gifford Agency, an Indiana-based firm providing asset ... of Campagna Academy in a charity drive to provide for at-risk children and teens ... Campagna Academy is a nonprofit organization that has offered critical programs to at-risk and ...
(Date:8/18/2017)... ... August 18, 2017 , ... With over 16,000 active ... hormone replacement therapy and integrative medicine, has become a frontrunner for people seeking ... as menopause, andropause, thyroid disorder and adrenal insufficiencies. , Founded in 2003 ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Aug. 15, 2017   Mostyn Law and Gulf Coast ... Houston, Texas . The Mostyn Law family has ... years. That is why Mostyn Law is partnering with ... to show its appreciation. Blood supplies are running low. ... short of hospital needs in August. That is why the blood ...
(Date:8/15/2017)... 15, 2017  AOTI Inc. announced today that its fully owned ... recently opened a New York City Office in Yonkers, ... unique Topical Wound Oxygen (TWO 2 ) homecare therapy. This new ... for Health Care (ACHC) under the company,s DMEPOS accreditation for Home/Durable ... Advanced ...
(Date:8/8/2017)... AVIV, Israel, Aug. 8, 2017  BioLineRx Ltd. (NASDAQ/TASE: ... immunology, today reports its financial results for the second ... achievements during the second quarter 2017 and to date: ... multiple clinical development programs for the Company,s lead project, ... 3 pivotal study with BL-8040 as novel stem cell ...
Breaking Medicine Technology: