Navigation Links
Blood test for colon cancer screening beneficial for some seniors, but not for many others
Date:5/9/2011

CHAPEL HILL, N.C. A new study of U.S. veterans ages 70 and older finds that the healthiest get the most benefit from current colon cancer screening methods. However, for many less healthy veterans the burdens of screening may outweigh the benefits.

"This study shows that we really need to target screening in older adults, so that those who will benefit do get screened and followed-up while those who won't benefit aren't exposed to unnecessary burdens," said Christine E. Kistler, MD, assistant professor of Family Medicine at the University of North Carolina at Chapel Hill and lead author of the study.

The study was published online on May 9, 2011, by the journal Archives of Internal Medicine. Kistler led the study while completing a geriatrics fellowship at the University of California, San Francisco and the San Francisco Veterans Affairs Medical Center. She has since joined the faculty at the UNC School of Medicine.

In the study, 212 patients ages 70 and older who were treated at four Veterans Affairs medical facilities were followed for 7 years after receiving a positive result in a fecal occult blood test (FOBT). The test, which determines whether or not occult (hidden) blood is present in the stool, is the most common method used in the VA health system as an initial screen for colon cancer. A follow-up colonoscopy within one year is recommended for patients with a positive FOBT.

The study found that a little more than half of the patients received a follow-up colonoscopy. Among those who did, more than 25 percent were found to have significant disease such as precancerous adenomas or cancer, were treated, and survived for more than five years. However, 59 percent of those who received follow-up colonoscopy did not have cancer, 16 percent died of other causes within 5 years, and 10 percent suffered complications from either colonoscopy or cancer treatment.

Among those who did not receive follow-up colonoscopy, nearly half died of other causes within five years of their positive FOBT. Four patients ultimately died of colon cancer -- three within the first 5 years of their positive FOBT.

Of the 212 patients in the study, the researchers defined 33 patients, a little more than 15 percent, as receiving a net benefit from their positive FOBT. Another 30 patients, about 14 percent, were defined as receiving indeterminate benefit. The remaining 149 patients, about 70 percent, were defined as receiving a net burden from colorectal cancer screening.

Kistler said there was "a spectrum of burden" among those in the net burden group. For some the burden was that they never received a follow-up colonoscopy. Others received a colonoscopy but it found no evidence of cancer, and some died of causes other than colon cancer. In each of these examples, the patients received no benefit as a result of their positive FOBT, Kistler said.

"This study shows that we need to do a better job of targeting colon cancer screening to those seniors who are healthy and functional and are likely to benefit. At the same time, this study also shows that we need to seriously examine why those seniors who are not likely to benefit are being subjected to colon cancer screening," Kistler said.


'/>"/>

Contact: Tom Hughes
tahughes@unch.unc.edu
919-966-6047
University of North Carolina School of Medicine
Source:Eurekalert

Related medicine news :

1. Adalimumab levels detected in cord blood and infants exposed in utero
2. Blood Pressure May Hint at Kidney Cancer Outcome
3. Structured Exercise Programs Help Lower Blood Sugar, Study Finds
4. Religion Doesnt Help Lower Blood Pressure, Study Suggests
5. Living with a smoker may raise blood pressure in boys
6. Death Rates Among People With High Blood Pressure Falling
7. Self-powered, blood-activated sensor detects pancreatitis quickly and cheaply
8. Experts Offer New Guidance for Blood Pressure Control in Elderly
9. Newer Pill Linked to Higher Risk of Blood Clots
10. Mexican-American Children Have High Levels of Flame-Retardants in Blood
11. Heart drugs could cut blood pressure risks in pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2016)... ... 2016 , ... The Society for Women’s Health Research (SWHR) announced that its ... role. , “No one in Washington led the way to advance women’s health research ... MD, PhD. “We offer our deep gratitude to Phyllis for her passion and performance ...
(Date:5/23/2016)... , ... May 23, 2016 , ... ... on its Chesterfield, Missouri, campus, Standard Process Inc. awarded $6,000 in ... Siewert and Chloe Tillman. Each student is in her fifth trimester of classes ...
(Date:5/23/2016)... ... May 23, 2016 , ... Hadley ... worldwide for people who are blind or visually impaired, announces the election of ... President Charles E. Young. Hadley’s Board of Trustees retained Morris & Berger, a ...
(Date:5/23/2016)... ... May 23, 2016 , ... Four Circles Recovery Center, a leading treatment ... to announce the launch of its new extended care program, Fifth Circle. Available for ... Four Circles or another primary treatment program, Fifth Circle is designed to foster the ...
(Date:5/23/2016)... ... 23, 2016 , ... Bio-Optronics, Inc. is delighted to announce ... its recent and anticipated growth. , Max Elbaz was appointed as Vice President, ... segments. Max joined the Bio-Optronics team in March. His areas of expertise include ...
Breaking Medicine News(10 mins):
(Date:5/19/2016)... 19, 2016 BioLineRx Ltd. (NASDAQ/TASE: ... the treatment of multiple cancer and hematological indications, will ... An abstract titled " Clinical response in relapsed/refractory AML ... by BL-8040, a potent CXCR4 antagonist; results of a ... presentation at the European Hematology Association 21st Congress, to ...
(Date:5/19/2016)... and CAMBRIDGE, Massachusetts , May 19, ... in the development of pharmaceuticals and diagnostics based on the ... a new office in Cambridge, MA ... US. The office is located at Kendall Square, ... industry, well-known as the global hub for transforming scientific insights ...
(Date:5/18/2016)... May 19, 2016 ... Research Report initially provides a basic overview ... and manufacturing technology, post which the report ... in the market. Complete report ... pages providing 8 company profiles and 98 ...
Breaking Medicine Technology: