Navigation Links
Blood test could predict metastasis risk in melanoma
Date:4/14/2011

PHILADELPHIA Scientists at Yale University have identified a set of plasma biomarkers that could reasonably predict the risk of metastasis among patients with melanoma, according to findings published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

"The rate at which melanoma is increasing is dramatic, and there is a huge number of patients under surveillance," said Harriet Kluger, M.D., associate professor of medicine at Yale University School of Medicine. "Our current method of surveillance includes periodic imaging, which creates huge societal costs."

Melanoma is the fifth most common cancer in men and the seventh most common cancer in women. It is estimated that 68,130 people in the United States were diagnosed in 2010, and 8,700 died. With proper screening, melanoma can often be caught early enough to be removed with surgery, and mortality typically comes when the cancer metastasizes. The risk of metastasis varies from less than 10 percent for those with stage 1A melanoma, to as high as 70 percent with stage 3C.

Patients with melanoma are typically subjected to a combination of imaging tests, blood tests and physical examinations, but there is no clear consensus on how often these tests should occur or how reliable they are.

Kluger and colleagues tested the plasma of 216 individuals, including 108 patients with metastatic melanoma and 108 patients with stage 1 or 2 disease. They identified seven plasma biomarkers: CEACAM, ICAM-1, osteopontin, MIA, GDF-15, TIMP-1 and S100B.

All of these biomarkers were higher in patients with metastatic melanoma than patients with early-stage disease. In fact, 76 percent of patients with early-stage disease had no elevations at all whereas 83 percent of metastatic patients had elevations of at least one marker. Researchers calculated that the area under the curve, a measure of the test's reliability, was 0.898. Area under the cur
'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New ACE survey shows people with type 2 diabetes experience low blood sugar during typical daily activities
2. Brisk Walk Can Boost Blood Flow to the Brain: Report
3. Higher Rate of Morning Heart Attacks Not Due to Blood Pressure: Study
4. Research shows blood protein levels may predict risk of a cardiovascular event: Study
5. Blood Marker Suggests Severity of Alzheimers Disease
6. Device drops blood pressure in patients with difficult-to-treat hypertension
7. Dangerous blood pressure increases during exercise can be blocked, UT Southwestern researchers find
8. Blood Test Holds Hope for Spotting Lung Cancer in Nonsmokers
9. University of Cincinnati team to track tumor DNA through bloodstream
10. CDC issues updated bloodstream infection prevention guidelines
11. Remove childrens catheters as soon as possible to prevent bloodstream infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... Gone are the days when throngs of ... Friday, which signifies the beginning of the Christmas shopping season. ... carts in the comfort of their homes or on the ... is going to be an occasion with one of the ... $2.48 billion in revenue for online retailers according to Adobe ...
(Date:11/26/2014)... With Thousand Oaks cosmetic dental work and ... Anacapa Dental Art Institute in Woodland Hills and Oxnard, Calif., ... some. , That is why they offer a variety of ... dentist wants cost to come between a patient and a ... Reshad, partner in the Anacapa Dental Art Institute. “That’s why ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 Anthropologists ... effectiveness in containing and stopping Ebola, improve international ... in healthcare systems in West Africa. , ... to Stop Ebola: Anthropologists Offer Insights,” will be ... the American Anthropological Association (AAA), Fri., Dec. 5, ...
(Date:11/26/2014)... Rouge, Louisiana (PRWEB) November 26, 2014 ... neck pain relief and specialists in minimally invasive ... K. Samer Shamieh into the rapidly growing provider ... specialists. The addition coincides with the network’s ... reliable medical treatment for Louisiana residents who are ...
(Date:11/26/2014)... 25, 2014 (HealthDay News) -- Vultures have developed highly ... ingest when eating dead animals, researchers report. The ... on the faces and in the guts of 50 ... On average, the faces of the vultures had more ... in their guts, the study found. The findings ...
Breaking Medicine News(10 mins):Health News:2014 Best Friday Deals Revealed by Top10InAction 2Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 2Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 3Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 4Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 5Health News:Anthropologists Release Recommendations, Better Practices to Contain Ebola 2Health News:Anthropologists Release Recommendations, Better Practices to Contain Ebola 3Health News:Louisiana Back Institute Welcomes Dr. K. Samer Shamieh into Medical Provider Network 2
... at the Puget Sound Health Care System, obese adults ... a recently discovered 'hunger hormone' than either normal-weight people ... David E. Cumming from the Puget Sound Health Care ... hormone called ghrelin could curb appetite and may cut ...
... study, zinc supplements could play a role in reducing the ... who tested three different methods of zinc administration in nearly ... diarrhea// defined as lasting more than seven days by 35 ... whether the zinc was given by a clinic worker or ...
... to researchers , there is a new study on ... sickened 30 people across six Western states last summer ... outbreak of Salmonella serotype senftenberg// most often found in ... grapes. ,Dr.Alicia, at the International Conference on Emerging ...
... up to almost one-half of their whole energy intake from ... a significant impact on their health.// ,Dr. Debra K. ... they get the nutrients, they get the energy they need, ... shown that snacking is growing among US children, who consume ...
... at Texas, have enrolled 10 patients with early stage bladder ... which is used for pancreatic and non-small cell lung cancer ... directly into the bladder, through a tube, and found that ... might be why there were few, if any, side effects ...
... talks about harmful radiations started during war times. Korean ... radiation emitted from radar equipment were no more likely ... lung, brain and testicular cancers--over a 40-year period//, according ... exposure to radar waves those who repaired and tested ...
Cached Medicine News:Health News:Decrease of 'Hunger Hormone' after Obesity Surgery 2Health News:Grapes, Melons Implicated in Outbreaks 2Health News:Healthy snacks improve nutrition of kids 2Health News:Microwave radiation has no hazards 2
(Date:11/26/2014)... 26, 2014 China Nepstar Chain Drugstore Ltd. (NYSE: ... leading retail drugstore chain in China based on the ... financial results for the third quarter ended September 30, 2014. ... , Same store sales increased by 8.1% compared ... increased by 8.1% to RMB738.3 million (US$120.3 million) compared to ...
(Date:11/24/2014)... 2014 Juno Therapeutics today announced that ... the company,s JCAR015 chimeric antigen receptor product candidate. ... or refractory B-cell acute lymphoblastic leukemia and was ... Cancer Center, where Phase 1 clinical trials are ... is important news for patients who may benefit ...
(Date:11/24/2014)... Nov. 24, 2014  Marta Rendon, MD, founder of the ... Raton , FL and international key opinion leader in dermatology, ... the United States to attend the international ... Turkey . Here, at this gathering of over 600 ... renowned facial plastic surgery experts from Asia ...
Breaking Medicine Technology:China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 2China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 3China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 4China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 5China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 6China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 7China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 8China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 9China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 10China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 11Juno T Cell Therapy For Leukemia Granted FDA Breakthrough Therapy Designation 2Juno T Cell Therapy For Leukemia Granted FDA Breakthrough Therapy Designation 3Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 2Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 3
... ArjoHuntleigh, Inc. is pleased to announce that it ... with HealthTrust Purchasing Group, L.P. (HealthTrust). The agreement, ... take advantage of special pricing and terms for ... for the prevention of deep vein thrombosis (DVT). ...
... 1, 2011 /PRNewswire-Asia-FirstCall/ -- China Medical Technologies, Inc. (the ... advanced in-vitro diagnostic ("IVD") company, today announced that it ... fiscal quarter ended September 30, 2011 ("2Q FY2011") before ... The Company,s senior management will host an earnings ...
Cached Medicine Technology:ArjoHuntleigh Awarded Vascular Compression Contract With HealthTrust Purchasing Group 2China Medical Technologies to Announce Results for the Second Fiscal Quarter Ended September 30, 2011 on November 18, 2011 2
Camera and light source in one compact "Plug-and-Play" device....
... are based on a completely new and revolutionary ... allows a tremendous image size without distortion. The ... the joint with less rotation of the telescope. ... tight and secure camera connection is introduced. It ...
... ProSpec, the system of choice for customers ... in medium throughput laboratories in more than ... milestone. Dade Behring is pleased to announce ... system., ,The customer centered development process ...
... Wavefront analysis with the WASCA Analyzer ... diagnosis. Unlike existing diagnostic techniques, the WASCA ... eye from thecornea to the retina. ... Analyzer also supplies higher order aberrations which ...
Medicine Products: