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Blood test could diagnose Alzheimer's disease, UT Southwestern researchers find
Date:10/5/2010

neurodegenerative disease or cognitive decline, Dr. Daz-Arrastia said.

Researchers associated with the Texas Alzheimer's Research Consortium, a five-university group funded by the state, carried out the research. In the current study, the scientists analyzed blood samples from 197 Texas patients who had suspected Alzheimer's and 203 people without the disease.

The researchers measured more than 100 blood proteins and created a mathematical analysis that could measure a person's risk of having Alzheimer's. The analysis, combined with information from a clinical exam, accurately detected Alzheimer's 94 percent of the time, and correctly ruled out Alzheimer's 84 percent of the time in people without the disease, Dr. Daz-Arrastia said.

Neither the blood test nor a clinical exam alone was as accurate on its own as the blood test and clinical exam combined, the researchers found.

"Having a diagnosis is an important step, but it's not the end of the road unless you've got a treatment or a cure," Dr. Daz-Arrastia said.

The next step in the work is to determine whether the biomarker test can detect accurately Alzheimer's in preserved blood serum from patients who have been diagnosed definitively by an autopsy.


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Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

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