Navigation Links
Blood test could diagnose Alzheimer's disease, UT Southwestern researchers find

DALLAS Oct. 6, 2010 A set of proteins found in blood serum shows promise as a sensitive and accurate way to diagnose Alzheimer's disease, researchers at UT Southwestern Medical Center have found as part of a statewide study.

An analysis of the proteins, plus a clinical exam, proved 94 percent accurate in detecting suspected Alzheimer's and 84 percent accurate in ruling it out in people without the disease, the researchers said.

"This research uses a novel technology that makes it possible to analyze several biomarkers in a single blood sample in a cost-effective way," said Dr. Ramn Daz-Arrastia, professor of neurology at UT Southwestern and senior author of the study which was published in the September issue of the Archives of Neurology.

Researchers have been seeking a simple blood test for Alzheimer's for years, Dr. Daz-Arrastia said, but no single substance, or "biomarker," has been shown to be useful. Such a test, he said, would be comparable in principle to measuring blood cholesterol as a biomarker of cardiovascular disease.

Alzheimer's disease is an incurable degenerative brain disease, which currently afflicts about 5.3 million people over 65 in the U.S., according to the National Alzheimer's Association. By 2050 that number is expected to reach 11 million or more.

The disease is difficult to diagnose, particularly in its early stages when it resembles other cognitive problems. Currently, a definitive diagnosis is possible only after examining the brain tissue of deceased individuals. Tests for suspected Alzheimer's are often expensive or invasive, and not every patient is able or willing to undergo them, the researchers stated.

A blood test would provide a convenient diagnostic method that could be performed by health care workers nearly anywhere. In addition, a definitive diagnosis is important because treatments specifically targeting Alzheimer's might not be effective against other forms of neurodegenerative disease or cognitive decline, Dr. Daz-Arrastia said.

Researchers associated with the Texas Alzheimer's Research Consortium, a five-university group funded by the state, carried out the research. In the current study, the scientists analyzed blood samples from 197 Texas patients who had suspected Alzheimer's and 203 people without the disease.

The researchers measured more than 100 blood proteins and created a mathematical analysis that could measure a person's risk of having Alzheimer's. The analysis, combined with information from a clinical exam, accurately detected Alzheimer's 94 percent of the time, and correctly ruled out Alzheimer's 84 percent of the time in people without the disease, Dr. Daz-Arrastia said.

Neither the blood test nor a clinical exam alone was as accurate on its own as the blood test and clinical exam combined, the researchers found.

"Having a diagnosis is an important step, but it's not the end of the road unless you've got a treatment or a cure," Dr. Daz-Arrastia said.

The next step in the work is to determine whether the biomarker test can detect accurately Alzheimer's in preserved blood serum from patients who have been diagnosed definitively by an autopsy.


Contact: Aline McKenzie
UT Southwestern Medical Center

Related medicine news :

1. USF and Saneron get $2.6 million to develop Alzheimers treatment using umbilical cord blood cells
2. Lack of Sleep During Pregnancy Ups Risk of High Blood Pressure
3. Short and long sleep in early pregnancy linked to high blood pressure in the third trimester
4. TGen-Mayo Clinic study discovers role of DNA methylation in multiple myeloma blood cancer
5. Study to investigate menstrual blood-derived stem cells as potential stroke therapy
6. Study of bloodstream infections reveals inconsistent surveillance methods and reporting
7. Atypical Antipsychotics Linked to Blood Clot Risk in Study
8. Blood Thinner OK for Superficial Leg Clots: Study
9. High Blood Sugar Levels Increase Infection Risk From General Surgery
10. Gene Rx May Fight Severe Blood Disorder
11. Blood test accurately predicts death from prostate cancer up to 25 years in advance
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... A simply groundbreaking television series, "Voices ... show that delves into an array of issues that are presently affecting Americans. Dedicated ... open dialogue, this show is changing the subjects consumers focus on, one episode at ...
(Date:11/27/2015)... ... November 27, 2015 , ... Keeping in mind challenges ... health and wellness consultation, has collaborated with a leading web-based marketplace for extra-curricular ... experienced by parents and bring advice from parenting experts within their reach. As ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... largest, most successful and prominent nonprofit healthcare organizations in the country. They have ... with various organizations, and helped advance the healthcare industry as a whole through ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... Avid collector, ... Ann Arbor Michigan boxing style concert posters. This is one of Joplin's most famous ... Canterbury House at the University of Michigan in Ann Arbor. The According to Hawley, ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients at Serenity Point ... come together on Thanksgiving Day to share the things that they are most ... Serenity Point YouTube channel, patients displayed what they wrote on index cards, describing ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 Research and Markets ( ... Wound Care Market by Type (Dressings, Therapy Devices, Active ... Facility, Out-Patient Facility), and Geography - Global Forecast to ... --> --> The purpose of ... forecast of the global advanced wound care market. It ...
(Date:11/26/2015)... November 26, 2015 ... "Self Administration of High Viscosity Drugs" report ... has announced the addition of the "Self ... their offering. --> Research and Markets ... the "Self Administration of High Viscosity Drugs" ...
(Date:11/26/2015)... , November 26, 2015 ... the addition of the  "2016 Future ... European Cell Surface Marker Testing Market: ...  report to their offering.  --> ... addition of the  "2016 Future Horizons ...
Breaking Medicine Technology: