Navigation Links
Blood test could diagnose Alzheimer's disease, UT Southwestern researchers find
Date:10/5/2010

DALLAS Oct. 6, 2010 A set of proteins found in blood serum shows promise as a sensitive and accurate way to diagnose Alzheimer's disease, researchers at UT Southwestern Medical Center have found as part of a statewide study.

An analysis of the proteins, plus a clinical exam, proved 94 percent accurate in detecting suspected Alzheimer's and 84 percent accurate in ruling it out in people without the disease, the researchers said.

"This research uses a novel technology that makes it possible to analyze several biomarkers in a single blood sample in a cost-effective way," said Dr. Ramn Daz-Arrastia, professor of neurology at UT Southwestern and senior author of the study which was published in the September issue of the Archives of Neurology.

Researchers have been seeking a simple blood test for Alzheimer's for years, Dr. Daz-Arrastia said, but no single substance, or "biomarker," has been shown to be useful. Such a test, he said, would be comparable in principle to measuring blood cholesterol as a biomarker of cardiovascular disease.

Alzheimer's disease is an incurable degenerative brain disease, which currently afflicts about 5.3 million people over 65 in the U.S., according to the National Alzheimer's Association. By 2050 that number is expected to reach 11 million or more.

The disease is difficult to diagnose, particularly in its early stages when it resembles other cognitive problems. Currently, a definitive diagnosis is possible only after examining the brain tissue of deceased individuals. Tests for suspected Alzheimer's are often expensive or invasive, and not every patient is able or willing to undergo them, the researchers stated.

A blood test would provide a convenient diagnostic method that could be performed by health care workers nearly anywhere. In addition, a definitive diagnosis is important because treatments specifically targeting Alzheimer's might not be effective against other forms of neurodegenerative disease or cognitive decline, Dr. Daz-Arrastia said.

Researchers associated with the Texas Alzheimer's Research Consortium, a five-university group funded by the state, carried out the research. In the current study, the scientists analyzed blood samples from 197 Texas patients who had suspected Alzheimer's and 203 people without the disease.

The researchers measured more than 100 blood proteins and created a mathematical analysis that could measure a person's risk of having Alzheimer's. The analysis, combined with information from a clinical exam, accurately detected Alzheimer's 94 percent of the time, and correctly ruled out Alzheimer's 84 percent of the time in people without the disease, Dr. Daz-Arrastia said.

Neither the blood test nor a clinical exam alone was as accurate on its own as the blood test and clinical exam combined, the researchers found.

"Having a diagnosis is an important step, but it's not the end of the road unless you've got a treatment or a cure," Dr. Daz-Arrastia said.

The next step in the work is to determine whether the biomarker test can detect accurately Alzheimer's in preserved blood serum from patients who have been diagnosed definitively by an autopsy.


'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. USF and Saneron get $2.6 million to develop Alzheimers treatment using umbilical cord blood cells
2. Lack of Sleep During Pregnancy Ups Risk of High Blood Pressure
3. Short and long sleep in early pregnancy linked to high blood pressure in the third trimester
4. TGen-Mayo Clinic study discovers role of DNA methylation in multiple myeloma blood cancer
5. Study to investigate menstrual blood-derived stem cells as potential stroke therapy
6. Study of bloodstream infections reveals inconsistent surveillance methods and reporting
7. Atypical Antipsychotics Linked to Blood Clot Risk in Study
8. Blood Thinner OK for Superficial Leg Clots: Study
9. High Blood Sugar Levels Increase Infection Risk From General Surgery
10. Gene Rx May Fight Severe Blood Disorder
11. Blood test accurately predicts death from prostate cancer up to 25 years in advance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... February 24, 2017 , ... ... Senior International Elite division on February 12th. Ms. Esparza qualified into this ... elite qualifier competition held in Las Vegas, Nevada. Frida is one of approximately ...
(Date:2/23/2017)... ... 23, 2017 , ... On February 22, 2017 the U.S. ... to withdraw previous guidance issued by the Obama Administration requiring schools to treat ... 2016 by the Obama Administration came in response to a growing number of ...
(Date:2/23/2017)... ... February 23, 2017 , ... Rare ... audience, will be participating in Rare Disease Day events, hosted by the Rare ... Rare Disease Report, a website, weekly e-newsletter and quarterly publication, will be conducting ...
(Date:2/23/2017)... ... February 23, 2017 , ... Hamlin Dental Group and Dr. Hamid ... sponsoring a raffle. Throughout the month of February, patients who visit Hamlin Dental Group ... for a dinner for two at the Cheesecake Factory. , Tickets are available ...
(Date:2/23/2017)... ... February 23, 2017 , ... On April 13, 2017, ... “Doping in Sport: How the Culture Might Change,” in conjunction with ... symposium will be held at Pepperdine University in Malibu, California. , Sir Philip ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... , Feb. 23, 2017  Genesis Healthcare Services has ... announcement was made by Bill Monast , President ... and Nathan Feltman , executives with Home ... Services, LLC. This acquisition helps Hospice ... of technology enabled durable medical equipment (DME) solutions for ...
(Date:2/23/2017)... 23, 2017  Cogentix Medical, Inc. (NASDAQ: CGNT), a ... proprietary products for the urology market, will release financial ... December 31, 2016 before the market open on Thursday, ... host a conference call and webcast to discuss its ... 2017 at 11:00 a.m. Eastern Time (10:00 a.m. Central ...
(Date:2/23/2017)... Calif., Feb. 23, 2017 Nevro Corp. (NYSE: NVRO), ... solutions for the treatment of chronic pain, today reported financial ... 31, 2016. 2016 Accomplishment & Highlights: ... year 2016, an increase of 228% as reported, over the ... 2016, an increase of 612% over the prior year ...
Breaking Medicine Technology: