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Blood proteins predict survival in idiopathic pulmonary fibrosis, Pitt-led team says
Date:10/25/2011

f the proteins, called MMP7, in the blood. Patients with a low PCMI were more likely to live more than 5 years while the median survival for patients with high PCMI scores was 1.5 years.

"This indicates that these blood biomarker levels are not just a reflection of current severity of the lung disease, but they are predictive of impending death," said lead author Thomas Richards, Ph.D., assistant professor of medicine and head of the Simmons Center biostatistics team.

"They have the potential to greatly improve our treatment strategies for IPF, in part by showing us which patients have the most urgent need for lung transplant, which is currently the only cure for the disease," added senior author Kevin Gibson, M.D., medical director of the Simmons Center.

"These findings provide proof of the concept of personalized medicine. " noted Mark T. Gladwin, M.D., chief, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine. "We can use a combination of biological and clinical markers to determine the very best care for each patient.

Drs. Kaminski, Gibson and colleagues have research projects underway to better understand how the biomarkers change over time.

The team includes Kathleen O. Lindell, Ph.D., R.N., and others at the Simmons Center and Pitt School of Medicine, as well as researchers from Centocor R & D in Radnor, Pa.

Study results will be presented by Dr. Kaminski at the IPF session of the Pittsburgh International Lung Conference on Personalized Medicine of Lung Disease at 2:30 p.m. on October 28 and 29 at the Holiday Inn Pittsburgh University Center.


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Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

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