Navigation Links
Blood proteins predict survival in idiopathic pulmonary fibrosis, Pitt-led team says
Date:10/25/2011

PITTSBURGH, Oct. 25 A panel of blood proteins can predict which patients with the progressive lung disease idiopathic pulmonary fibrosis (IPF) are likely to live at least five years or to die within two years, say researchers at the University of Pittsburgh School of Medicine and Centocor R&D. The findings, published online last week in the American Journal of Respiratory and Critical Care Medicine, could help doctors determine those patients in imminent need of a lung transplant and those who can wait a while longer.

Fifty percent of IPF patients die within three years of diagnosis, but others will do well for long periods of time, explained investigator Naftali Kaminski, M.D., professor of medicine, pathology, human genetics and computational biology, Pitt School of Medicine, and director, The Dorothy P. & Richard P. Simmons Center for Interstitial Lung Disease at UPMC. In the disease, breathing becomes increasingly impaired as the lungs progressively scar.

"It's hard to tell based on symptoms alone which patients are in the greatest danger," Dr. Kaminski said. "This biomarker panel has predictive power that can guide our treatment plan. It may also help us design more effective research trials because we'll be able to better match experimental therapies with the most appropriate patients."

The research team collected blood samples from 241 IPF patients. They measured the levels of 92 candidate proteins in 140 patients and found that higher concentrations of five particular proteins that are produced by the breakdown of lung tissue predicted poor survival, transplant-free survival and progression-free survival regardless of age, sex and baseline pulmonary function. They then confirmed the results in a second group of 101 patients.

Based on both groups, the investigators developed the personal clinical and molecular mortality prediction index (PCMI) that incorporates the gender, lung functions and levels of one o
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Inflammatory Bowel Ups Risk for Blood Clots
2. Bowel disease link to blood clots
3. Local Blood Supply Impacted by Wednesdays Severe Snow Storm
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. China Cord Blood Corporation Warrant Registration Statement Declared Effective by SEC
6. NIH grants to Childrens Hospital will advance novel stem cell treatments for blood disorders
7. Bilberry Seems to Act Against Blood Sugar
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
10. NHLBI, CDC launch surveillance and research program for inherited blood diseases
11. IOM report declares high blood pressure a neglected disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... One of the most popular vaccine brands for children ... may be overlooking some cost factors when choosing vaccines, ... expensive option, according to a new study by University ... administer can be driven by numerous factors," says Sheldon ... professor of computer science and of mathematics at the ...
(Date:4/17/2014)... a review published in the April issue of ... Feinstein Institute for Medical Research, says it,s time to ... approach to treating sepsis, which kills millions worldwide ... occurs when molecules released into the bloodstream to fight ... Inflammation is necessary for maintaining good health without ...
(Date:4/17/2014)... It,s estimated that as many as 10 million older ... of loneliness and isolation. , However, new research ... retired older Americans for six years found that ... of depression by more than 30 percent. , "That,s ... State University professor of telecommunication, information studies and media ...
(Date:4/17/2014)... YORK April 17, 2014 EcoHealth Alliance, a ... health issues, published a comprehensive review today examining the ... Marburg virus. The review calls for improved global surveillance ... as the recent outbreak of Ebola in West Africa ... the countries of Guinea and Liberia. According to ...
(Date:4/17/2014)... uncommon these days to find a colored ribbon representing a ... cancer. But what color ribbon does one think of with ... color, for many suffering from the disease, black may be ... study consisting of lung cancer patients, primarily smokers between the ... light on the stigma often felt by these patients, the ...
Breaking Medicine News(10 mins):Health News:Study recalculates costs of combination vaccines 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Internet use can help ward off depression among elderly 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 3Health News:Unraveling the 'black ribbon' around lung cancer 2
... Women experiencing physical abuse from intimate partners spent 42 percent ... to a long-term study of more than 3,000 women. , ... study revealed that women who suffered physical abuse five or ... on health care than women who were never abused. , ...
... Gray of Chicago, IL, will travel to Washington, D.C., ... meet with congressional leaders and gain their support for ... cure for epilepsy.Gray, 9, is one of 37 young ... Speak Up! , a national program coordinated by the ...
... the European UnionEAST PROVIDENCE, R.I., March 23 ... the innovative IlluminOss(TM) Photodynamic Bone Stabilization System for ... granted a CE Mark. The approval permits ... European Union (EU).IlluminOss Medical is beginning the process ...
... Healthcare ProfessionalsVOORHEES, N.J., March 23 The epidemiology ... changing rapidly and has been marked by a ... CDI can be challenging and guidelines for treatment ... effectively implement key strategies for reducing the incidence ...
... African Health Conference in Kenya SILVER SPRING, Md., ... a communications, research, and technology firm, will share the ... mobile video-enabled phones in meeting the requirements for monitoring ... East African Health and Scientific Conference. The findings ...
... MALVERN, Pa., March 23 Fujirebio Diagnostics, Inc., ... leader in cancer biomarker assays, today announced the ... Officer. Dr. Barnes comes to Fujirebio Diagnostics ... has held various positions at Abbott and Meridian ...
Cached Medicine News:Health News:Physical abuse raises women's health costs over 40 percent 2Health News:Illinois Youth Shares Epilepsy Message on Capitol Hill 2Health News:IlluminOss(TM) Photodynamic Bone Stabilization System Receives CE Mark 2Health News:Clostridium difficile Infection in Primary Care: Tackling a Virulent Pathogen 2Health News:Pilot Study Using Video Cell Phones for Mobile Direct Observation Treatment (MDOT) to Monitor Medication Compliance of TB Patients 2Health News:Pilot Study Using Video Cell Phones for Mobile Direct Observation Treatment (MDOT) to Monitor Medication Compliance of TB Patients 3Health News:Pilot Study Using Video Cell Phones for Mobile Direct Observation Treatment (MDOT) to Monitor Medication Compliance of TB Patients 4Health News:Fujirebio Diagnostics Appoints Grady Barnes as Chief Scientific Officer 2
(Date:1/15/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces ... condition to the announced tender offer for all of the outstanding ... result of the waiver, the transaction is no longer conditional on ... January 24, 2014 following the currently scheduled expiration time, subject to ...
(Date:1/15/2014)... BEACH GARDENS, Fla. , Jan. 15, 2014  In an unprecedented ... difficile and TB in ambulances and other transport vehicles, an advanced ... used by rescue personnel for the first time. ... in contact with these deadly pathogens, West Palm Beach ...
(Date:1/15/2014)... Jan. 15, 2014 The Cadence Fitness & Health ... by the Medical Fitness Association, a non-profit organization assisting ... full potential. The Cadence Fitness & Health Center is ... and second in the Chicagoland area. "The ...
Breaking Medicine Technology:Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Superbugs No Longer Ride In Rescue Vehicles 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3
... Guard Against,Hospital Infections, KANSAS CITY, Kan., April 02, ... ten leading causes of death in the,United States, ... countless stories about patients who go into hospitals ... As a,patient, knowing the right questions to ask ...
... 2007--Rapamycin, an FDA-approved drug,normally used to help prevent ... and also used to coat cardiac stents, was,highly ... in mice. In a study published in the ... at the National,Cancer Institute (NCI), part of the ...
Cached Medicine Technology:Six Important Things to Know About Preventing Hospital Infections 2Six Important Things to Know About Preventing Hospital Infections 3Immunosuppressant Drug Prevents Tobacco Induced Lung Cancer in Mice 2Immunosuppressant Drug Prevents Tobacco Induced Lung Cancer in Mice 3Immunosuppressant Drug Prevents Tobacco Induced Lung Cancer in Mice 4
... Protection Made Easy. The new generation FilterWire ... and ease of use, providing you with ... stenting and angioplasty procedures., ,The FilterWire EZ ... requiring minimal changes to technique. The ...
... sizes, noise is not a factor with ... For use with mini-crocodile clip lead wires ... x 2.5 cm (.875 x 1 in), ... 100-count package contains 10 individually sealed sets ...
... and patient information from all cardiology ... one central system. It simplifies the ... so that healthcare professionals can focus ... people., ,Many Sources, One Solution ,Multi-modality ...
... Xi300 is so bright many surgeons turn it ... to shift into when the going gets tough. ... a true Hot Start and the technologically advanced ... that prevent failed start ups and overheating. The ...
Medicine Products: